A5100351616- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Microbial Metabolism and Applications
- Geomagnetism and Paleomagnetism Studies
- Asymmetric Hydrogenation and Catalysis
- Antibiotic Resistance in Bacteria
- Oral microbiology and periodontitis research
- Fungal and yeast genetics research
- Mass Spectrometry Techniques and Applications
- Circular RNAs in diseases
- Biosensors and Analytical Detection
- Salmonella and Campylobacter epidemiology
- Asymmetric Synthesis and Catalysis
- Viral Infectious Diseases and Gene Expression in Insects
- Chemical Synthesis and Reactions
- Synthesis and Catalytic Reactions
- Immune cells in cancer
- Antimicrobial agents and applications
- Nanocomposite Films for Food Packaging
- Plant Gene Expression Analysis
- Adipose Tissue and Metabolism
- Polyamine Metabolism and Applications
- Liver Disease Diagnosis and Treatment
Hainan Medical University
2023-2024
Hainan General Hospital
2023-2024
Shenzhen Bay Laboratory
2023-2024
Hainan University
2019-2024
Chinese PLA General Hospital
2023
Liaoning Shihua University
2023
East China University of Technology
2022
Henan Agricultural University
2020
Haikou City People's Hospital
2019
Beijing Children’s Hospital
2019
Ginsenoside Rb1 (Rb1), a natural compound extracted from ginseng, exerts anti-obesity activity and improves insulin sensitivity in high-fat diet (HFD)-induced obese rats. The objective of the current study was to evaluate protective effect on fatty liver HFD-induced rats elucidate underlying mechanisms. After chronic intraperitoneal administration, (10 mg/kg) significantly ameliorated hepatic fat accumulation rats, as demonstrated by reduced weight, triglyceride content, histological...
This work evaluated 3-(2-isocyanobenzyl)-1 H -indole derivatives as quorum sensing inhibitors for the control of Pseudomonas aeruginosa infections in vitro .
Activation of spermine/spermidine- N 1 -acetyltransferase (SSAT) leads to DNA damage and growth arrest in mammalian cells, its ablation reduces the severity ischemic endotoxic injuries. Here we have examined role SSAT pathogenesis toxic liver injury caused by carbon tetrachloride (CCl 4 ). The expression activity increase subsequent CCl administration. Furthermore, early after treatment was significantly attenuated hepatocyte-specific knockout mice (Hep-SSAT-Cko) compared with wild-type (WT)...
Summary The effects of Caulerpa lentillifera (CL) extract incorporation on antioxidant activity, antibacterial water stability, and physical properties the chitosan/gelatin (CS/GEL) films were studied. CL containing CS/GEL composite film was prepared by casting method. effect content (1%, 3%, 5%) properties, thermal property, mechanical barrier stability contact angle evaluated. With increase content, bumps micro‐pores appeared surface cross‐section films. angle, solubility, absorption...
N6-methyladenosine (m6A) modification is the most common mRNA that considered a new layer of epigenetic regulation. Demethylase fat mass and obesity-associated protein (FTO) are important in dynamic regulation m6A, but their role gastric cancer (GC) not fully understood. This study revealed FTO CDKAL1 were up-regulated GC cells tissue. downstream target FTO-mediated m6A modification, with promoting cell proliferation through inducing mitochondrial fusion, eventually causing chemoresistance....
A highly active palladium-based heterogeneous catalyst with excellent activity for the hydrogenation of oximes to form amines was prepared.
Quorum sensing (QS) inhibition has emerged as a promising target for directed drug design, providing an appealing strategy developing antimicrobials, particularly against infections caused by drug-resistant pathogens. In this study, we designed and synthesized total of 33 β-nitrostyrene derivatives using 1-nitro-2-phenylethane (NPe) the lead compound, to facultative anaerobic bacterial pathogen
Neighboring gene pairs in the genome of Saccharomyces cerevisiae have a tendency to be expressed at same time. The distribution histone modifications along chromatin fibers is suggested an important mechanism responsible for such coexpression. However, extent contribution coexpression neighboring genes unclear.We investigated similarity modification between using autocorrelation analysis and composite profiles. Our showed that had similar levels or changes modifications, especially those...
The spirooxindoles have broad and promising activities in various therapeutic areas, become a privileged skeleton for drug discovery.Therefore, the development of some simple efficient strategies to build these sophisticated scaffolds has one most widespread concerns.However, traditional methods are limited by separation purification intermediates, functional group protection de-protection.Recently, cascade shown special advantages synthesis optically active natural products complex...
Playing a significant role in electrochemical energy conversion and storage systems, heteroatom-doped transition metal oxides are key materials for oxygen-involving reactions. Herein, mesoporous surface-sulfurized Fe-Co3O4 nanosheets integrated with N/S co-doped graphene (Fe-Co3O4-S/NSG) were designed as composite bifunctional electrocatalysts the oxygen evolution reaction (OER) reduction (ORR). Compared Co3O4-S/NSG catalyst, it exhibited superior activity alkaline electrolytes by delivering...
Quorum sensing (QS) inhibition is recognized as a novel antimicrobial target for infections caused by drug-resistant pathogens and an attractive strategy antipathogenic agent development. We designed synthesized three parts of 3-(2-isocyanobenzyl)-1H-indole derivatives tested their activity quorum inhibitors (QSIs). 3-(2-Isocyanobenzyl)-1H-indole demonstrated promising QS, biofilms, prodigiosin inhibitory activities against Serratia marcescens at subminimum concentrations (sub-MICs). In...
An efficient and convenient method for the construction of diverse free (N-H)-benzazepinoindoles by Pd-catalyzed C(sp2)-H imidoylative cyclization 3-(2-isocyanobenzyl)-1H-indoles was developed. The reaction shows a wide substrate scope can be scaled up, providing practical route to valuable bioactive azepinoindoles.
Abstract Recent micromagnetic simulations have found that particles in the transitional zone between single domain (SD) and vortex (SV) are prone to thermal external magnetic field instabilities could adversely affect accuracy of interpretations paleomagnetic recordings. In this study, we attempt evaluate internal magnetization characteristics these magnetically unstable (MU) influence on observations by simulating behavior 68–104 nm truncated octahedral magnetite using MERRILL modeling...
Campylobacter jejuni (C. jejuni), a foodborne pathogenic bacterium, is among the most prevalent causes of human gastroenteritis globally. We developed and evaluated loop-mediated isothermal amplification (LAMP) method to detect C. jejuni. Outer primers inner were designed based on hipO gene. The ratio between concentrations outer reaction temperature then optimized achieve optimal assay conditions. analytical specificity tests showed that, 12 genera 74 pure bacterial culture strains, only...
Chloroplast less mutants of E gracilis and intermedia were generated by treatment with Ofloxacin Absorption spectra autofluorescence microscopic observations showed that chlorophyll was not synthesized in the two Using DAPI fluorescence photomicrograph, plastid DNA found Astasia longa , a colorless species Euglenoid, but ofloxacin induced Euglena, which suggest plastids have been completely lost SDS PAGE indicated specific proteins wild type mutant strains respectively
Abstract Quorum sensing (QS) inhibition is recognized as a novel drug target for infections caused by drug-resistant pathogens and an attractive strategy the development of antipathogenic agents. Herein, we designed synthesized three parts of3-(2-isocyanobenzyl)-1H-indole derivatives evaluated their activity quorum inhibitors (QSIs). We found that 3-(2-isocyanobenzyl)-1H-indole showed promising QS inhibitory in minimum concentrations (MICs), biofilm prodigiosin assays Serratia marcescens ....
Die Charakterisierung nativer Proteine gelingt durch extrahierende Elektrosprayionisations-Massenspektrometrie (EESI-MS). Wie H. Chen und Mitarbeiter in ihrer Zuschrift auf S. 3117 ff. ausführen, werden native bei der EESI mit Ladungen belegt, ohne dass ein starkes elektrisches Feld benötigt wird. Das Verfahren erleichtert massenspektrometrische Studien, auch an biologischen Rohproben, vermeidet signifikante Konformationsänderungen Aktivitätsverluste.
Abstract Background At present, genome editing at specific sites in vivo is affected by many factors, including the choice of vector, efficiency proteins and influence internal environment. These factors make gene ineffective even have adverse effects. Methods Here, we report a single rAAV containing SaCas9 guide RNAs under control subtle EF1a tRNA promoters. The capacity was compressed, inserted sequence green fluorescent protein eGFP into rAAV. vitro analyzed time point virus titer. In...