A5047773598- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Aortic Disease and Treatment Approaches
- Anesthesia and Sedative Agents
- T-cell and B-cell Immunology
- Caveolin-1 and cellular processes
- Biliary and Gastrointestinal Fistulas
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Oral Health Pathology and Treatment
- Viral-associated cancers and disorders
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Renal cell carcinoma treatment
- Leptospirosis research and findings
- Phytochemistry and Bioactive Compounds
- Pharmacy and Medical Practices
- FOXO transcription factor regulation
- Chemokine receptors and signaling
Zhengzhou University
2021-2025
Second Affiliated Hospital of Zhejiang University
2022-2024
Chinese PLA General Hospital
2024
China Medical University
2013-2024
First Hospital of China Medical University
2023
Peking University
2022
Peking University First Hospital
2022
National Natural Science Foundation of China
2020
First Affiliated Hospital of Chinese PLA General Hospital
2014
Jinan Central Hospital
2010
Lymph nodes are the most common metastasis sites for tumor cells, which intimately linked to patient prognosis. It has been reported that cancer cells can upregulate CC Chemokine Receptor 7 (CCR7) expression and hijack its normal functions, enabling them migrate along gradient of CCL19 CCL21 toward lymph colonies as initial stage distant metastasis. In patients, metastatic in exhibited higher CCR7, well inhibitory immune checkpoints PD-1, LAG-3, TIM-3 compared primary tumors with analysis...
Abstract Background and Aims The secretion of bile salts transported by the salt export pump (BSEP) is primary driving force for generation flow; thus, it closely related to formation cholesterol stones. Caveolin‐1 (Cav‐1), an essential player in cell signalling endocytosis, known co‐localize with cholesterol‐rich membrane domains. This study illustrates role Cav‐1 BSEP stone formation. Methods Adult male C57BL/6 mice were used as animal model. HepG2 cells cultured under different...
Abstract Background The pupillary response to tetanic electrical stimulation reflects the balance between nociceptive and analgesia. Although pain index (PPI) was utilized predict postoperative pain, it depended on complex. We aim describe potential relationship PD in presence of surgical levels after awakening. Methods According Verbal Rating Scale (VRS) score extubation, patients were divided into painless group (VRS = 0) ≥ 1). Pupillary diameter (PD) light reflex velocity (PLRV) compared...
Abstract Chronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced modified. However, whether tumor‐derived (TDEs) influenced by participate stress‐mediated distant metastasis remains unclear. Here, it is shown that remarkably facilitates secretion of TDEs modifies contents activating adrenergic β receptor 4T1 tumor‐bearing mice. Exosomes injection...
Neoadjuvant chemotherapy (NAC) for breast cancer enables pathological complete response (pCR) in patients initially diagnosed with axillary lymph node metastases, potentially obviating the need dissection (ALND). Current targeted (TAD) techniques, guided by traditional tissue markers placed prior to NAC, face challenges such as marker loss and high costs. Carbon nanoparticle suspension injection (CNSI) offers a stable reliable alternative marking, which could enhance TAD procedure. This...
Background The development of cancer is largely dependent on the accumulation somatic mutations, indicating potential to develop chemoprevention agents targeting mutation drivers. However, ideal that can effectively inhibit drivers have not been identified yet. Methods signatures and expression analyses APOBEC3B were performed in patient with pan-cancer. computer-aided screening skeleton-based searching identify natural products activity APOBEC3B. 4-nitroquinoline-1-oxide (4-NQO)-induced...