A5100388158- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Inflammasome and immune disorders
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Phytochemical compounds biological activities
- Berberine and alkaloids research
- Phytochemical Studies and Bioactivities
- Genomics, phytochemicals, and oxidative stress
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Fungal Biology and Applications
- Polysaccharides Composition and Applications
- Ginger and Zingiberaceae research
- Veterinary medicine and infectious diseases
- Particle Dynamics in Fluid Flows
- Sesquiterpenes and Asteraceae Studies
- Glutathione Transferases and Polymorphisms
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Bioactive Compounds
- Autoimmune and Inflammatory Disorders Research
- Tannin, Tannase and Anticancer Activities
Shanghai University of Traditional Chinese Medicine
2022-2025
Beijing University of Chinese Medicine
2014-2024
ZheJiang Institute For Food and Drug Control
2023
Chengdu University of Traditional Chinese Medicine
2014-2023
Buchang Pharma (China)
2023
Tianjin University of Traditional Chinese Medicine
2019-2022
Heilongjiang University of Chinese Medicine
2022
Hong Kong Baptist University
2018-2020
Hong Kong Polytechnic University
2020
Guangxi University of Chinese Medicine
2020
Prunellate A (1), an unprecedented lignan lactone bearing a 6/7/6/5 tetracyclic system with C-2–C-2′ and C-7–C-8′ single bond linkage, probably derived from the rearrangement of methyl rosmarinate (2), has been isolated medicinal plant Prunella vulgaris. An extensive interpretation multispectroscopic data including HRMS, IR, 1D, 2D NMR elucidated its structure. The stereochemical assignment was conclusively established through electronic circular dichroism (ECD) experiments. possible...
Ziyuglycoside II is one of the major active compounds Sanguisorba officinalis L., which has a wide range clinical applications including hemostasis, antibiosis, anti-inflammation and anti-oxidation. This study investigated effect ziyuglycoside on growth human breast carcinoma MDA-MB-435 cells for first time. The results showed that could significantly inhibit through blocking cell cycle progression at G0/G1 S phase as well via inducing apoptosis. Accumulation reactive oxygen species (ROS)...
Schisandra Fructus (SF) is a traditional Chinese herb used in the treatment of inflammatory disorders like hepatitis. One main anti-inflammatory components SF lignans. However, underlying mechanism Chinensis lignans (SCL) remains unclear. This study aims to investigate effects SCL on mediators lipopolysaccharide-stimulated RAW264.7 cells and explore mechanism. The production nitric oxide (NO) was determined by Griess reaction. ELISA determine cytokine levels chemokines secretion. To estimate...
Abstract: The aim of the study was to improve oral absorption compound 25-OCH 3 -PPD with poor hydrophilicity and lipophilicity. -PPD-phospholipid complex prepared by solvent evaporation, then characterized differential scanning calorimetry, electron microscopy, infrared spectroscopy. aqueous solubility oil–water partition coefficient were compared free compound. A nanoemulsion loaded developed dissolving in water presence hydrophilic surfactant under sonication. After administration...
Hepatocellular carcinoma (HCC), the major form of primary liver cancer, is a common cause cancer-related death worldwide. Signal transducer and activator transcription 3 (STAT3) signaling constantly activated in HCC has been proposed as chemotherapeutic target for HCC. Antrodia camphorata (AC), medicinal mushroom unique to Taiwan, traditionally used treating Whereas natural AC scarce, cultured mycelia are becoming alternatives. In this study, we investigated anti-HCC effects ethyl acetate...
Pterocephalus hookeri (C. B. Clarke) Hock., a traditional Tibetan herbal medicine rich in glycosides, has been used to treat several diseases including rheumatoid arthritis.To evaluate the anti-arthritic activity of total glycosides from P. hookeri, and its possible mechanisms action.Anti-arthritic (oral administration for 30 days at 14-56 mg/kg) was evaluated using paw swelling, arthritis scores histopathological measurement adjuvant-induced (AA) Sprague-Dawley rats. The NF-κB p65...
Five new triterpenoids, including four ursane types (1-4) and one oleanane type (5), together with 15 known pentacyclic triterpenoids (6-20) were isolated from the fruit spikes of Prunella vulgaris L., a traditional Chinese herbal medicine. Their structures elucidated based on IR, HR-ESI-MS, NMR spectroscopic data. The SW579 cell line was used to evaluate anti-thyroid cancer activities (1-20). results indicated that (7-9), (16), (19) exhibited apparent inhibitory activity IC50 values...
Purpose: Sichen (SC) formula is a classic prescription of Tibetan medicine. Due to its potential anti-inflammatory effect, the SC has been clinically used treat respiratory diseases for many years in Chinese Tibet region. The present study aimed investigate effect and explore underlying mechanisms. Methods: was characterized by HPLC analysis. acute lung injury (ALI) mouse model induced direct intratracheal lipopolysaccharide (LPS) instillation, bronchoalveolar lavage fluid (BALF) tissues...
Four dammarane-type, three lupane-type, and an oleanane-type triterpenes named foliasalacins A1 (1), A2 (2), A3 (3), A4 (4), B1 (5), B2 (6), B3 (7), C (8) were isolated from the leaves of Salacia chinensis LINN. collected in Thailand. The structures new triterpene constituents (1—8) characterized on basis chemical physiochemical evidence.
Three new oleanane-type triterpene saponins, named pithelucosides A−C (1–3), together with two known saponins (4, 5) were isolated from the roots of Pithecellobium lucidum. The structures established on basis extensive 1D and 2D NMR experiments mass spectrometry confirmed by acid alkaline hydrolysis. Compounds 1–5 7 (pro-sapogenin obtained mild hydrolysate 1) evaluated for cytotoxic activity five human tumoral cell lines (HCT-8, Bel-7402, BGC-823, A549, A2780) hemolytic property against...
Herba Siegesbeckiae (HS, the dried aerial part of Siegesbeckia orientalis L.) is a commonly used traditional Chinese medicinal herb for treating inflammatory diseases. HS has been reported to exert anti-inflammatory effects by inhibiting MAPKs and NF-κB pathways, downstream effectors TLR4 signalling. This study aims further investigate involvement signalling cascades in an ethanolic extract (HS short) on mediators murine macrophages. was extracted using 50% ethanol. Lipopolysaccharide...
High shear wet granulation (HSWG) is a shaping process for that has been enhanced application in the pharmaceutical industry. However, study of HSWG complex and challenging due to relatively poor understanding HSWG, especially sticky powder-like herbal extracts.In this study, we used Salvia miltiorrhiza granules investigate across different scales using quality by design (QbD) approaches.A Plackett-Burman experimental was screen nine factors process. Moreover, quadratic polynomial regression...
Eleven novel ursolic acid (UA) derivatives were designed and synthesized with modification at positions of C-2, C-3, C-28 UA. Their structures confirmed by MS, 1H NMR, elemental analysis. in vitro cytotoxicities against various cancer cell lines (HeLa, HepG2, BGC-823) evaluated MTT assay. The results indicated that all compounds could inhibit proliferation HeLa, BGC-823 cells. Among them, I3 I4 showed more potent cytotoxicity on these three tumor cells than gefitinib (positive control),...