Oral administration of insulin (INS) could be absorbed into systemic circulation only if the carrier protected it from hostile gastrointestinal conditions. However, traditional macromolecular carriers have not totally overcome challenges in addressing these biological barriers.In this study, inspired by small molecule natural products (SMNPs), we demonstrate multi-functional self-assembly nanoparticles (BA-Al NPs) originating baicalin (BA) and AlCl3 through coordination bonds hydrogen bonds....

Abstract High shear wet granulation (HSWG) has been wildly used in manufacturing of oral solid dosage (OSD) forms, and process modeling is vital to understanding controlling this complex process. In paper, data fusion multivariate technique were applied develop a formulation-process-quality model for HSWG The experimental from both literature the authors’ laboratory fused into single formatted representation. A material database matching method compensate incomplete physical characterization...

The purpose of this study is to use a material library investigate the effect raw properties on ribbon tensile strength (TS) and solid fraction (SF) in roll compaction (RC) process. A total 81 pharmaceutical materials, including 53 excipients 28 natural product powders (NPPs), were characterized by 22 descriptors compacted under five different hydraulic pressures. transversal longitudinal splitting behaviors ribbons summarized. TS-porosity TS-pressure relationships used explain behavior...

In order to improve the performance of welded joints in Al-Li alloys, butt consisting 2 mm thick 2195-T8 alloy plates are fabricated by laser beam welding with different filler wires this paper. The ER2319CT, ER4047, and without investigated context microstructure, distribution alloying elements, burning loss tensile strength. From fusion boundary center weld seam (WS), crystal morphologies vary sequence fine equiaxed grains, columnar dendrite, dendrite. grains dendrite disappear certain...

High shear wet granulation (HSWG) is a shaping process for that has been enhanced application in the pharmaceutical industry. However, study of HSWG complex and challenging due to relatively poor understanding HSWG, especially sticky powder-like herbal extracts.In this study, we used Salvia miltiorrhiza granules investigate across different scales using quality by design (QbD) approaches.A Plackett-Burman experimental was screen nine factors process. Moreover, quadratic polynomial regression...

Abstract Ionic polymer metal composites (IPMCs) are widely studied as actuators and sensors, due to their large bending motion, flexibility being light-weight. Nowadays, IPMCs used in the bionic field, for example, achieve twisting movements of wings fins. In this paper, a method is proposed optimize torsion performance by changing electrode separation. The with patterned fabricated masking technique accomplish motion. result indicates that improved separation increased. Thereby it provides...

The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario unclear, and the impact of sample size on modeling worth discussing. In this work, direct compression was taken as research object, effects different sizes libraries partial least squares (PLS) prediction tablet tensile strength were investigated. A primary comprising 45 built. Then, subsets...

Abstract In this paper, an improved Genetic Algorithm (IGA) is proposed to optimize the BP-LSTM neural network for predicting heat exchanger temperature. The study introduces enhanced genetic algorithm designed both short- and long-term memory networks (LSTM) in conjunction with BP temperature prediction model model. Simulation comparison results demonstrate that method can effectively forecast temperatures.

The purpose of this study was to describe the raw material variability that influenced in-vitro dissolution behavior high drug-load sustained-release matrix tablet and ensure consistent quality final product. Panax notoginseng saponins (PNS) - hydroxypropyl methylcellulose anhydrous lactose magnesium stearate (57:20:23:0.5%, w/w) used as model formulation. PNS extract powders with lot-to-lot source-to-source differences were collected cover common cause variations their physicochemical...

Statistical modeling methods to analyze the impacts of multiunit process variability on critical quality attributes Chinese herbal medicine tablets Fei Sun,1 Bing Xu,1,2 Yi Zhang,1 Shengyun Dai,1 Chan Yang,1 Xianglong Cui,1 Xinyuan Shi,1,2 Yanjiang Qiao1,2 1Research Center Traditional Medicine Information Engineering, School Materia Medica, Beijing University Medicine, 2Key Laboratory Manufacture Process Control and Quality Evaluation Beijing, People’s Republic China Abstract: The suffers...

Near-infrared spectroscopy was used to monitor the end point of elution process for purification Gardenia jasminoides Ellis (gardenia) extract. A partial least square model built quantify concentration geniposide. new strategy coupled with multivariate statistical control update original calibration correct fluctuations among batch processes and enhance robustness model. After updating twice by strategy, root mean squared error prediction decreased from 0.505 0.350 mg mL−1, interval between...

The dissolution is one of the critical quality attributes (CQAs) oral solid dosage forms because it relates to absorption drug. In this paper, influence raw materials, granules and process parameters on paracetamol tablet was analyzed using latent variable modeling methods. variability in materials understood based principle component analysis (PCA), respectively. A multi-block partial least squares (MBPLS) model used determine factors affecting dissolution. results showed that binder...

In this paper, the material library approach was used to uncover pattern of tabletability change and related risk for tablet formulation design under roll compaction dry granulation (RCDG) process. 31 materials were fully characterized using 18 physical parameters 9 compression behavior classification system (CBCS) parameters. Then, each granulated sieved into small granules (125–250 μm) large (630–850 μm), respectively. The by CBCS descriptors, compared with that ungranulated powders....

Understanding the tabletability change of materials after granulation is critical for formulation and process design in tablet development. In this paper, a material library consisting 30 pharmaceutical was used to summarize pattern during high shear wet tableting (HSWGT). Each powdered corresponding granules were characterized by 19 physical properties nine compression behavior classification system (CBCS) parameters. Principal component analysis (PCA) compare behaviors ungranulated powders...

It is imperfect to evaluate a subsampling variable selection method using only its prediction performance. To further assess the reliability of methods, dummy noise variables different amplitudes were augmented original spectral data, and false number was recorded. The reliabilities three methods including Monte Carlo uninformative elimination (MC‐UVE), competitive adaptive reweighted sampling (CARS), stability CARS (SCARS) evaluated this strategy. evaluation results indicated that both...