A5008948379- Helicobacter pylori-related gastroenterology studies
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Pharmacological Effects of Natural Compounds
- Spine and Intervertebral Disc Pathology
- Sarcoma Diagnosis and Treatment
- Inflammatory Bowel Disease
- Child and Adolescent Psychosocial and Emotional Development
- Gastrointestinal motility and disorders
- Cancer-related molecular mechanisms research
- Renal and Vascular Pathologies
- Gut microbiota and health
- Galectins and Cancer Biology
- Esophageal and GI Pathology
- Natural product bioactivities and synthesis
- Functional Brain Connectivity Studies
- Metastasis and carcinoma case studies
- Mycobacterium research and diagnosis
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- Supramolecular Self-Assembly in Materials
People's Hospital of Xinjiang Uygur Autonomous Region
2015-2025
Ningbo University Affiliated Hospital
2025
Second Xiangya Hospital of Central South University
2020-2024
Central South University
2011-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Union Hospital
2024
Beijing Institute of Technology
2023-2024
University of Chinese Academy of Sciences
2019-2024
Diarrhea-predominant irritable bowel syndrome (IBS-D) is one common chronic functional disease of the digestive system with limited treatments. The microbiota–gut–brain axis (MGBA) has a central function in pathogeny IBS-D, which includes participation many various factors, such as brain-gut peptides (BGPs), immune inflammation and intestinal flora. Inspired by drug combination traditional Chinese medicine (TCM), our previous study discovered that BBR BA could form natural self-assemblies...
Childhood trauma (CT) is a well-established risk factor for major depressive disorder (MDD). However, the underlying mechanism linking CT and MDD remains not fully understood. The present study tested hypothesis that have effects on specific types of anhedonia in depression via reward system. To do so, we evaluated different aspects resting-state functional connectivity (FC) system among 66 patients with (44 moderate-to-severe 22 no or low CT), 57 healthy controls (HC; 23 34 CT). Results...
Isorhamnetin, kaempferol, myricetin, and quercetin are four kinds of secondary metabolites in sea buckthorn, which have a wide range biological activities. Investigating their interactions with tyrosinase at the atomic level can improve bioavailability buckthorn. Both molecular docking dynamics simulation methods were employed to study these ligands tyrosinase. The results indicated that small molecules such as isorhamnetin, all dock into active center tyrosinase, by occupying site, they...
Abstract On‐surface reactions of terminal alkynes in ultrahigh vacuum have attracted widespread attention due to their high technological promise. However, employing different precursors and substrate materials often intricate reaction schemes appear far from being well‐understood. Thus, recent investigations alkyne coupling on noble metal surfaces suggest non‐dehydrogenative scenarios, contradicting earlier reports. Herein, the study employs noncontact atomic force microscopy (nc‐AFM) with...
<title>Abstract</title> <bold>Background</bold> This study aimed to explore the diversity of gut microbial profiles and their associations with dietary habits metabolites in different ethnic groups disease states. By conducting microbiome metabolomic analyses on 192 healthy diseased individuals (including those hypertension, type II diabetes, co - morbidities) Xinjiang, it strived offer new insights into role microbes metabolic diseases, which could potentially contribute early diagnosis...
<title>Abstract</title> Background Hiatal hernia (HH) is a major cause of gastroesophageal reflux disease (GERD), and laparoscopic repair combined with anti-reflux surgery common treatment. However, postoperative complications such as vagus nerve injury remain concern. This study introduces novel Laparoscopic "Tunnel" Approach aiming to minimize damage the preserve perigastric vessels. Methods A retrospective analysis was conducted on 106 patients who underwent for HH GERD at First...
This study examined the computational cognitive mechanisms of visual working memory (VWM) in MDD, focusing on precision while exploring potential sex differences. 159 Major Depressive Disorder (MDD) patients and 67 healthy controls (HC) completed color delay estimation task to measure their VWM. The mainstream models VWM were compared, variable-precision (VP) model was best fit for our data. Bayesian ANCOVA used compare differences between groups (MDD & HC) sexes (male female). Results...
Summary Background Epidemiological data of coeliac disease are lacking from the central Asian region. Aims To verify occurrence amongst four major ethnic groups Xinjiang Uyghur Autonomus Region, China. Methods 2277 in‐patients with gastrointestinal symptoms (1391 Han, 608 Uyghur, 146 Kazakh and 132 Hui; mean age: 54 ± 12.8 years) were included. Total IgA, anti‐deamidated gliadin peptide (DGP)‐IgG, anti‐tissue transglutaminase (anti‐tTG)‐IgA analysed. All antibody‐positive subjects further...
Fibrotic liver injury is a progressive scarring event, which may permanently affect function and progress into devastating end-stage diseases due to the absence of effective therapies. Si-Wu-Tang (SWT), traditional Chinese medicine formula used in clinic treat gynecological disorders for centuries, has been investigated recent preliminary findings its role alleviating chronic diseases. Here we aim elucidate therapeutic effects possible mechanisms SWT against fibrotic injury.UHPLC-MS/MS was...
Abstract The present study investigated the effect of childhood trauma (CT) on amygdala and hippocampus functional connectivity (FC) association with clinical presentations major depressive disorder (MDD). Participants included 73 MDD patients (42 moderate-to-severe CT 31 no or low CT) 64 healthy controls (HC; 30 34 CT). Seed-based whole-brain resting-state FC analyses were performed seeds located in hippocampus. Individuals CT, irrespective diagnosis, had decreased right amygdala–right...
The aim of this study was to investigate the causal relationship between autoimmune disorders and celiac disease (CeD) through Mendelian randomization (MR). Single nucleotide polymorphisms (SNPs) significantly associated with 13 diseases were extracted from summary statistics European genome-wide association studies (GWAS), their effects examined by Inverse variance-weighted (IVW) in a large GWAS on CeD. Finally, reverse MR performed CeD traits. Following application Bonferroni correction...
Abstract Based on the antibody typing classification, Helicobacter pylori infection can be divided into type I H. and II infection. To observe effects of different types distribution histopathological characteristics levels three items serum gastric function (PG I, PG II, G-17). 1175 cases from October 2018 to February 2020 were collected with ratio 1:2. All patients performed 14 C-Urea breath test ( C-UBT), detection, painless gastroscopy, pathological examination, etc. According groups:...
BACKGROUNDGastric Helicobacter pylori (H.pylori) infection is related to chronic gastritis, gastroduodenal ulcer, and gastric malignancies; whether this colorectal polyps cancer (CRC), remains debatable. AIMTo investigate the relationship between H. risk of CRC. METHODSWe retrospectively analyzed 3872 patients with who underwent colonoscopy pathological diagnosis.We also 304 primary CRC.The characteristics these were compared those control group, which included 2362 normal intestinal...
The efficacy of dapagliflozin and empagliflozin in sodium-glucose cotransport-2 inhibitors (SGLT-2i) patients with heart failure (HF) has been discovered. However, which drug could improve varied prognostic outcomes not elucidated. Hence, we compared their efficacies on the improvement HF.
Considering that natural products as tyrosinase inhibitors are considered to be safe, with little or no toxic side effects and friendly the environment, it is urgent develop a new recognition strategy for inhibitors. In current study, an integrated computational analysis was conducted on Cys-containing dipeptides high inhibitory activity. Firstly, molecular fingerprint similarity (FS) clustering performed target molecule using machine learning. Secondly, genetic algorithm used construct two...
Background A growing number of studies have implicated that gut microbial abundance and metabolite concentration alterations are associated with celiac disease (CD). However, the causal relationship underlying these associations is unclear. Here, we used Mendelian randomization (MR) to reveal effect microbiota metabolites on CD. Methods Genome-wide association study (GWAS) summary-level data for microbiota, metabolites, CD were extracted from published GWASs. Causal bacterial taxa determined...