A5077839253- GDF15 and Related Biomarkers
- Nuclear Receptors and Signaling
- Nutrition and Health in Aging
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Signaling Pathways in Disease
- Macrophage Migration Inhibitory Factor
- Cerebrovascular and genetic disorders
- Cancer, Stress, Anesthesia, and Immune Response
- interferon and immune responses
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Breast Cancer Therapies
- Protease and Inhibitor Mechanisms
- Apelin-related biomedical research
- Financial Reporting and Valuation Research
- Molecular Sensors and Ion Detection
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Estrogen and related hormone effects
Hong Kong Baptist University
2020-2024
Abstract Obesity, a global health challenge, is major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There an ongoing need to identify safe tolerable therapeutics obesity management. Herein, we show that treatment with artesunate, artemisinin derivative approved by the FDA of severe malaria, effectively reduces body weight improves metabolic profiles in preclinical models obesity, male mice overnutrition-induced cynomolgus macaques...
Abstract Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-associated insulin resistance remains unknown. Here, we identify membrane-bound matrix metalloproteinase 14 (MT1-MMP/MMP14) as a central regulator of during ageing. Ageing promotes MMP14 activation in insulin-sensitive tissues, which cleaves Receptor to suppress signaling. MT1-MMP inhibition restores expression, improving aged mice. The cleavage by also contributes obesity-induced and...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (memACE2) undergoes ectodomain shedding to generate shed soluble (solACE2) that mediates SARS-CoV-2 via receptor-mediated endocytosis. Currently, it not known how the physiological regulation contributes etiology COVID-19 in vivo. present study identifies Membrane-type 1 Matrix...
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of with poor prognosis. Here, we present peptide–drug conjugate (PDC)─bradykinin-potentiating peptide-paclitaxel (BPP-PTX) conjugate─synthesized by conjugating BPP9a PTX via succinyl linker. BPP-PTX targets the angiotensin-converting enzyme (ACE) on TNBC cells. ACE was found to be ectopically expressed in two cell lines but absent both receptor-positive line and healthy kidney line. Overexpression, knockdown, competitive...
Objective To investigate the clinical features and surgical treatment of cerebral amyloid angiopathy hemorrhage (CAAH) caused by vascular amyloidosis. Methods The data, radiological diagnoses, pathology results efficacies 76 patients with CAAH, admitted to performed surgery in our hospital from August 2010 September 2015, were retrospectively analyzed. Results The first preoperative CT indicated that prompt hematomas located hemisphere brain cortex, forming lobulated or...