A5102716600- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Sulfur Compounds in Biology
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Amino Acid Enzymes and Metabolism
- HER2/EGFR in Cancer Research
- Antimicrobial Peptides and Activities
- Luminescence and Fluorescent Materials
- Monoclonal and Polyclonal Antibodies Research
- Bioactive Compounds and Antitumor Agents
China Pharmaceutical University
2023-2024
Qinghai University for Nationalities
2024
State Ethnic Affairs Commission
2020
Minzu University of China
2018
Peptide–drug conjugates (PDCs) are an emerging targeted therapeutic drug following on from the relative success of antibody–drug (ADCs). In this class, peptides used to target payload molecules at disease sites, thereby reducing toxicity and improving physicochemical properties payload. A PDC is composed three parts: peptide, linker toxin molecule, in structure, selection addition affinity stability peptide keys PDCs. Since development ADCs, drugs have undergone several updates – can PDCs...
Abstract A novel peptide‐based chemical fluorescence sensor L (Dansyl‐His‐Pro‐Thr‐Cys‐NH 2 ) was designed and synthesized. This exhibits an “On–Off–On” detection cycle to detect Cu 2+ , Zn S 2− in solution. According the chelation‐enhanced (CHEF) mechanism, when is present, significantly enhanced a blue shift occurs, representing “Turn‐On” phase of mode. Because copper ions (Cu have paramagnetic quenching sensing quenches rapidly with formation ‐Cu system, “Turn‐Off” phase. The subsequent...