A5088550019- Fluoride Effects and Removal
- Bone and Dental Protein Studies
- Mechanisms of cancer metastasis
- Folate and B Vitamins Research
- Dental Health and Care Utilization
- Delphi Technique in Research
- Wnt/β-catenin signaling in development and cancer
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Amino Acid Enzymes and Metabolism
- Oral and Maxillofacial Pathology
- Ginseng Biological Effects and Applications
- Cancer Mechanisms and Therapy
- Gut microbiota and health
- Immune cells in cancer
- Magnesium in Health and Disease
- Digestive system and related health
- Extracellular vesicles in disease
- Pharmacological Effects of Medicinal Plants
- dental development and anomalies
- HER2/EGFR in Cancer Research
- Advanced Glycation End Products research
- Oral microbiology and periodontitis research
- Bone Tumor Diagnosis and Treatments
- Therapeutic Uses of Natural Elements
Kunming University of Science and Technology
2024
Chinese Center For Disease Control and Prevention
2020-2023
Harbin Medical University
2019-2023
Air Force Medical University
2013-2020
Poorly differentiated colorectal cancers (CRCs) are more aggressive and lack targeted therapies. We others previously reported the predominant role of tumor-suppressor NDRG2 in promoting CRC differentiation, but underlying mechanism is largely unknown. Herein, we demonstrate that induction cell differentiation dependent on repression E3 ligase Skp2 activity. In patients Ndrg2 knockout mice, negatively correlated associated with stage. Further, suppression contributes to inductions...
ABSTRACT HER2‐overexpressing breast cancers often show hyperactivation of the HER2/AKT/mTOR signaling pathway. Lapatinib is an oral dual tyrosine kinase inhibitor (TKI) that targets both EGFR and HER2 to inhibit proliferation cancer cells. However, it obscure whether how lapatinib could induce autophagy in cells, important cell response with drug treatment. In this study, we investigated apoptosis cells BT474 AU565 treated lapatinib, further examined their relationship. inhibited rate DNA...
It's well known that microenvironment inflammatory signals could promote cancer development and progression. In colorectal (CRC), chronic inflammation is a major driving mechanism for the of CRC in patients having long-standing bowel disease (IBD). Though it has been addressed cells ferment much their glucose supply into lactate regardless presence oxygen, unclear whether cell metabolism reprogramed during process from IBD to CRC. Herein, with dextran sulfate sodium (DSS)-induced mouse...
BackgroundParacellular barriers play an important role in the pathogenesis of Inflammatory bowel disease (IBD) and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumour suppressor inhibit colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation colitis-associated is unclear.MethodsIntestine-specific Ndrg2 deficiency mice (Ndrg2ΔIEC) were subjected DSS- or TNBS-induced colitis, AOM-DSS-induced tumour. HT29 cells, Caco2...
Abstract Objectives The purpose of this study was to assess the gastroprotective properties alpha-boswellic acid (α-BA), a pentacyclic triterpene compound from extracts Frankincense. Methods gastroprotection α-BA assessed with ethanol-induced gastric lesions model, by histopathological assessment and measuring juice acidity (pH), wall mucus (GWM), prostaglandins E2 (PGE-2), membrane lipids peroxidation (MDA), superoxide dismutase (SOD) activity, catalase (CAT) activity amount nitric oxide...
Glycolysis and glutaminolysis are heavily involved in the metabolic reprogramming of cancer cells. The activation oncogenes inactivation tumor suppressor genes has a marked effect on cellular processes glycolysis glutaminolysis. N‑Myc downstream‑regulated gene 2 (NDRG2) is that previous studies have demonstrated can inhibit growth, proliferation metastasis clear cell renal carcinoma (ccRCC) However, function NDRG2 ccRCC metabolism remains unknown. In present study, significantly inhibited...
ABSTRACT Paracellular barriers play an important role in the pathogenesis of IBDs and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumor suppressor inhibits colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation colitis-associated is unclear. Here, We found that intestine-specific Ndrg2 deficiency caused mild spontaneous with ageing, aggravated DSS TNBS induced colitis, increased AOM-DSS tumor. loss led adherens...
Objective To investigate the effects of fluoride exposure dose and time on expression 5-methylcytosine (5-mC) in blood, liver, kidney brain rats; to understand whether there is a difference DNA methylation levels different tissues. Methods Eighty three-week old SPF male Wistar rats were randomly divided into four groups according body weight [(82.34 ± 10.60) g], with 20 each group. The control group drank distilled water group's containing 25, 50 100 mg/L F ion, respectively. Rats...
To investigate the relationship between fluoride exposure and Osteochondroma (OC) prevalence, a cross-sectional study was conducted in drinking water endemic fluorosis areas of Heilongjiang Province, China. Our first reported that prevalence OC 2.3% China, no difference gender. Logistic regression analysis found compared to 1st quartile participants, 73% lower 2nd participants WF (Water fluoride), 3.4 times higher among UF (Urinary fluoride) participants. suggests 0.259–0.420 mg/L may be...
Objective To investigate the effects of fluoride on protein oxidative damage in rat plasma by measuring stress levels, advanced glycation end products (AGEs) and oxidation (AOPP). Methods Eighty SPF male 3-week-old Wistar rats weighing (82.34 ± 10.60) g were randomly divided into 4 groups, 20 each group. The control group drank distilled water, groups water with concentrations 25, 50 100 mg/L, respectively. Rats allowed to eat drink freely, they sacrificed at 1 month 3 month,...
Abstract Background : Fluoride is an environmental chemical that has adverse effects on health, probably increasing osteoarthritis (OA) risk. However, whether fluoride a serious risk factor for OA still inconsistent among current evidence. The aim of this study was to determine the relationships between chronic exposure and residents living in Tongyu County, China 2019. Method 186 cases controls aged 26 86 years were recruited after x-ray examination with Kellgren Lawrence criteria by two...