A5103085133- Cell Adhesion Molecules Research
- Photosynthetic Processes and Mechanisms
- Light effects on plants
- Mechanisms of cancer metastasis
- Plant Molecular Biology Research
- RNA Research and Splicing
- Escherichia coli research studies
- RNA and protein synthesis mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Angiogenesis and VEGF in Cancer
- Platelet Disorders and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Glycosylation and Glycoproteins Research
- Enzyme Structure and Function
- Nanoparticles: synthesis and applications
- Plant Stress Responses and Tolerance
- Magnesium in Health and Disease
- Chronic Myeloid Leukemia Treatments
- Bacterial Genetics and Biotechnology
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Trace Elements in Health
- Proteoglycans and glycosaminoglycans research
Central South University
2024-2025
Tianjin University
2025
Xiangya Hospital Central South University
2024-2025
Shenyang Agricultural University
2020-2024
Air Force Medical University
2013-2023
State Key Laboratory of Cancer Biology
2014-2022
Taizhou People's Hospital
2021
Nantong University
2021
Ministry of Education of the People's Republic of China
2021
National Center of Biomedical Analysis
2009
Abstract Discoidin domain receptor 2 (DDR2) belongs to tyrosine kinase (RTK) family and is activated by collagen binding. Although the bone defects in Ddr2 null mice have been reported for a decade, molecular mechanism remains unclear. This study sought investigate function detailed of DDR2 osteogenic chondrogenic differentiation. Herein we found that preosteoblastic cells, activation was enhanced induction but not paralleled with alteration expression. Under differentiated condition,...
Abstract A wide range of genes involved in breast cancer metastasis have been reported to be related the microenvironment. We studied role discoidin domain receptor 2 ( DDR2 ), a collagen‐binding receptor, progression under hypoxic conditions. showed that protein expression closely correlated with marker HIF ‐1α clinical specimens. The vitro data demonstrated hypoxia treatment increased levels both and phosphorylation human cell lines. In vivo , orthotopic tumour xenografts knockdown...
Abstract Metallic nanoparticles (NPs) have potential applications in industry and medicine, but they also the to cause many chronic pulmonary diseases. Mechanisms for their cytotoxicity, glucose energy metabolism responses need be fully explained lung epithelial cells after treatment with metallic nanoparticles. In our study, two different (Fe 2 O 3 ZnO) cell‐based assays (BEAS‐2B A549 cell lines) were used. Our findings demonstrate that ZnO nanoparticles, not Fe induce cycle arrest,...
Perceiving incoming environmental information is critical for optimizing plant growth and development. Multiple B-box proteins (BBXs) play essential roles in light-dependent developmental processes plants. However, whether BBXs function as a signal integrator between light temperature tomato plants remains elusive. In this study, 31 SlBBX genes were identified from the newly released ( Solanum lycopersicum ) genome sequences clustered into five subgroups. Gene structure protein motif...
Abstract Cold stress is a key environmental constraint that dramatically affects the growth, productivity, and quality of tomato (Solanum lycopersicum); however, underlying molecular mechanisms cold tolerance remain poorly understood. In this study, we identified REDUCED CHLOROPLAST COVERAGE 2 (SlREC2) encoding tetratricopeptide repeat protein positively regulates tolerance. Disruption SlREC2 largely reduced abscisic acid (ABA) levels, photoprotection, expression C-REPEAT BINDING FACTOR...
Idiopathic pulmonary fibrosis (IPF) is a lethal human disease with short survival time and few treatment options. Herein, we demonstrated that discoidin domain receptor 2 (DDR2), tyrosine kinase predominantly transduces signals from fibrillar collagens, plays critical role in the induction of angiogenesis lung. In vitro cell studies showed DDR2 can synergize actions both transforming growth factor (TGF)-β collagen to stimulate lung fibroblasts undergo myofibroblastic changes vascular...
Plants experience low ambient temperatures and red to far-red ratios (L-R/FR) of light due vegetative shading longer twilight durations in cool seasons. Low induce photoinhibition through inactivation the photosynthetic apparatus, however, role quality on photoprotection during cold stress remains poorly understood. Here, we report that L-R/FR significantly prevents overreduction entire intersystem electron transfer chain limitation photosystem I (PSI) acceptor side, eventually alleviates...
Summary Plants have evolved sophisticated regulatory networks to cope with dynamically changing light and temperature environments during day–night seasonal cycles. However, the integration mechanisms of low remain largely unclear. Here, we show that red : far‐red ratio (LR FR) induces FAR‐RED ELONGATED HYPOCOTYL3 ( SlFHY3 ) transcription under cold stress in tomato Solanum lycopersicum ). Reverse genetic approaches revealed knocking out decreases myo ‐inositol accumulation increases...
Abstract Increasing photosynthesis and light capture offers possibilities for improving crop yield provides a sustainable way to meet the increasing global demand food. However, poor transmittance of transparent plastic films shade avoidance at high planting density seriously reduce alter fruit quality in vegetable crops, therefore it is important investigate mechanisms signaling regulation metabolism tomato (Solanum lycopersicum). Here, combination red, blue, white (R1W1B0.5) promoted...
Only serine phosphorylation of eukaryotic initiation factor-4E (eIF-4E) has been previously reported in intact cells. We found that treatment HepG2 cells with okadaic acid resulted as much 20% factor (eIF)-4E occurring on threonine residues and tryptic phosphopeptide maps showed several unrecognized phosphopeptides. Analysis p220 from control acid-treated demonstrated under both conditions. However, a unique pattern phosphopeptides was observed. The most notable finding hyperphosphorylation...
Abstract Discoidin domain receptor 2 ( DDR2 ) is a unique tyrosine kinase RTK that signals in response to collagen binding and implicated tumour malignant phenotypes such as invasion metastasis. Although it has been reported expression up‐regulated activated endothelial cells ECs ), functional studies are lacking. Herein, we found enforced of promoted proliferation, migration tube formation primary human umbilical vein HUVECs ). The results immunohistochemical analysis showed strikingly high...
Myocardial infarction (MI) is a common cause of mortality in people. Mesenchymal stem cell (MSC) has been shown to exert therapeutic potential treat myocardial (MI). However, patients with diabetes, the diabetic environment affected MSCs activity and could impair efficacy treatment. Interleukin-10 (IL-10) attenuate MI by suppressing inflammation. In current study, combination MSC transplantation IL-10 was evaluated mice model MI.We engineered bone marrow derived (BM-MSCs) overexpress using...
BackgroundParacellular barriers play an important role in the pathogenesis of Inflammatory bowel disease (IBD) and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumour suppressor inhibit colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation colitis-associated is unclear.MethodsIntestine-specific Ndrg2 deficiency mice (Ndrg2ΔIEC) were subjected DSS- or TNBS-induced colitis, AOM-DSS-induced tumour. HT29 cells, Caco2...
Rheumatoid arthritis (RA) is a multifactorial autoimmune disease that primarily manifests as persistent synovitis and progressive joint destruction. Imatinib exhibited therapeutic effect in murine collagen-induced (CIA) via selective inhibition tyrosine kinases. The second-generation kinase inhibitor dasatinib exhibits more durable hematological cytogenetic effects potency compared to imatinib. However, the of on CIA poorly understood. present study investigated treatment arthritis. We...
Naringenin-loaded monomethoxy poly(ethylene glycol)-poly (ε-caprolactone) (MPEG-PCL) nanoparticles (NARNP) and their formulation into buccal tablets using mucoadhesive polymers were developed to improve the solubility of naringenin treat oral inflammatory ulcerative diseases. In our work, physicochemical characterizations NARNP including particle size, zeta potential, transmission electron microscopy (TEM), differential scanning calorimetery, Fourier transform infrared spectroscopy in vitro...
Imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired imatinib resistance remains big hurdle. Molecular mechanisms for CML to tyrosine kinase inhibitors, beyond point mutations BCR-ABL domain, still need be addressed. Here, we demonstrated that thioredoxin-interacting protein (TXNIP) a novel target gene. Suppression TXNIP was responsible triggered glucose metabolic reprogramming mitochondrial homeostasis. Mechanistically, Miz-1/P300...
Objective This study was undertaken to uncover the pathophysiologic role of discoidin domain receptor 2 (DDR‐2), a putative fibrillar collagen receptor, in inflammation promotion and joint destruction rheumatoid arthritis (RA). Methods In synovial tissue from patients with RA mice antibody–induced (CAIA) (using Ddr2 −/− DBA/1 mice), gene protein expression levels DDR‐2, interleukin‐15 (IL‐15), Dkk‐1 were measured by quantitative reverse transcription–polymerase chain reaction, Western...
Background: Drug resistance is one of the biggest challenges in cancer therapy.temozolomide (TMZ) represents most important chemotherapeutic option for glioma treatment.However, therapeutic efficacy TMZ remains very limited due to its frequent glioma, and underlying mechanisms were not fully addressed.Herein, we demonstrate that elevated expression CD147 contributes cells, potentially through post-translational regulation Nrf2 expression.Methods: Cell-based assays triggered drug performed...
Type I human hepatic 3α-hydroxysteroid dehydrogenase (AKR1C4) plays a significant role in bile acid biosynthesis, steroid hormone metabolism, and xenobiotic metabolism. Utilization of hidden Markov model for predictive modeling nuclear receptor response elements coupled with chromatin immunoprecipitation/microarray technology revealed putative binding site the <i>AKR1C4</i> promoter known as liver X α, (LXRα [NR1H3]), which is physiological oxidized cholesterol metabolites. The LXRα element...