A5101972649- Advanced Drug Delivery Systems
- Biochemical Analysis and Sensing Techniques
- Proteoglycans and glycosaminoglycans research
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- melanin and skin pigmentation
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Polysaccharides and Plant Cell Walls
- Monoclonal and Polyclonal Antibodies Research
- Analytical Methods in Pharmaceuticals
- MicroRNA in disease regulation
- Drug Solubulity and Delivery Systems
- Heme Oxygenase-1 and Carbon Monoxide
- Postharvest Quality and Shelf Life Management
- Sesame and Sesamin Research
- Sunflower and Safflower Cultivation
- Cell Adhesion Molecules Research
- Gout, Hyperuricemia, Uric Acid
- Atherosclerosis and Cardiovascular Diseases
- Chemical Thermodynamics and Molecular Structure
- Collagen: Extraction and Characterization
- Hydrogels: synthesis, properties, applications
- Cancer Cells and Metastasis
Wenzhou Medical University
2024-2025
Xi'an Jiaotong University
2008-2024
Zhejiang A & F University
2023
Fujian Agriculture and Forestry University
2022
Naringenin-loaded monomethoxy poly(ethylene glycol)-poly (ε-caprolactone) (MPEG-PCL) nanoparticles (NARNP) and their formulation into buccal tablets using mucoadhesive polymers were developed to improve the solubility of naringenin treat oral inflammatory ulcerative diseases. In our work, physicochemical characterizations NARNP including particle size, zeta potential, transmission electron microscopy (TEM), differential scanning calorimetery, Fourier transform infrared spectroscopy in vitro...
Abstract In this experiment, ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was employed to quantify karacoline in mouse plasma following both intravenous and oral administration, thereby elucidating the pharmacokinetic characteristics of mice. The analytes were extracted from using acetonitrile for protein precipitation. Chromatographic separation performed on an HSS T3 column via gradient elution, with mobile phase consisting methanol 0.1% formic acid water....
Hydroxytyrosol (HT), a phenolic compound in olive oil, exerts an anti-inflammatory effect cardiovascular diseases. Recent studies found that autophagy was therapeutic target of However, the HT on vascular adventitial fibroblasts (VAFs) remains unknown. Thus, this study, we aimed to determine cell and related signaling pathway whether regulates inflammatory response through VAFs. Our results showed promoted by increasing conversion LC3 Beclin1 expression autophagic flux VAFs stimulated with...
Gellan gum hydrogel holds great potential in tissue engineering, but the high phase transition temperature greatly inhibits applications biomedical field. In this study, gellan was modified with methacrylic anhydride, and then reduced. The functionalized together type I collagen gelled by ion/photo dual-cross-linking for fabricating bone marrow-derived mesenchymal stem cells (BMSCs)-encapsulating vascularization. After ratio between optimized, proper pore size mechanical properties prepared....
Gardenia jasminoides Ellis is a widely cultivated garden plant, but its flower resources are underutilized. In this study, three pectic polysaccharides extracted from flowers (GFPPs) were obtained, including acid-extracted pectin (ACP), hot water-extracted (HWP), and alkaline-extracted (ALP). The physicochemical, structural, rheological, functional properties of GFPPs compared analyzed. results showed that the yield all exceeded 21%, proportion rhamnogalacturonan I (RG-I) regions ranged...
1. Plumage colour is an important recognisable characteristic of duck (Anas platyrhynchos), but the colouration mechanisms remain largely unknown. To elucidate molecular underlying formation black and white plumage, following study applied RNA sequencing (RNA-Seq) to catalogue global gene expression profiles in feather bulbs colours.2. Black were collected from Putian ducks (B-PTB) Longsheng Jade-green (B-LS), while White (W-PTW), (W-PTB) (W-LS). Sixteen cDNA libraries constructed sequenced...
In this study, we prepared gelatin-coated mesoporous hollow silica nanospheres (GSN) as a drug carrier to improve the water solubility and regulate release rate of glimepiride (GLM). GLM was loaded into GSN by an absorption method, drug-loaded samples (GLM-GSN) were characterized differential scanning calorimeter (DSC) X-ray diffraction (XRD). Cellular uptake in vivo intestinal experiments performed rats. addition, studies in-vitro dissolution, pharmacokinetics, pharmacodynamic also...
A new model of atherosclerosis cell membrane chromatography has been established by using a CD40 stationary phase (CD40 CMSP) prepared immobilizing the onto surface silica carrier. The and chromatographic characteristics CMSP were studied. retention anti-CD40 antibody statins (lovastatin, simvastatin pravastatin) also investigated this model. Affinities toward receptors based on determination log k′ values (the logarithm capacity factor solute). There was significant correlation between...
Objective: Difenidol is widely used in clinical practice due to its good anti-dizziness effect and low side rate. This aim was develop an ultra-high performance liquid chromatography- tandem mass spectrometry (UPLC-MS/MS) method for the selective straightforward measurement of diphenidol mouse plasma. Methods: A total eighteen mice were divided into three groups: six intravenous administration at a dose 0.2 mg/kg, oral 0.4 another 1.6 mg/kg. The analytes extracted using acetonitrile-mediated...
Objective To explore the role and mechanism of endoplasmic reticulum stress key molecule CHOP in regulating apoptosis autophagy. Methods Endoplasmic was induced by tunicamycin DU-145 cells. We detected expression stress-related proteins Grp78, Grp94, p-eIF2α, autophagic LC3Ⅱ, Atg5 Beclin1 Western Blot, then we analysed level apotosis flow cytometry. PARP Caspase3 Blot rate cytometry after silencing CHOP. The marker LC3B immunofluorescence assay CHOP. Results Tunicamycin could...