A5056488045- Epigenetics and DNA Methylation
- Marine and coastal ecosystems
- Biocrusts and Microbial Ecology
- Aquatic Ecosystems and Phytoplankton Dynamics
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Mechanisms of cancer metastasis
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Measurement and Detection Methods
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Advanced Sensor and Control Systems
- RNA modifications and cancer
- Spectroscopy and Laser Applications
- Gastric Cancer Management and Outcomes
- Gas Sensing Nanomaterials and Sensors
- Single-cell and spatial transcriptomics
- Advanced Fiber Optic Sensors
- Per- and polyfluoroalkyl substances research
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Chronic Myeloid Leukemia Treatments
- Ginseng Biological Effects and Applications
- Berberine and alkaloids research
Qufu Normal University
2023-2025
Air Force Medical University
2021-2024
Xijing Hospital
2021-2024
University of Shanghai for Science and Technology
2024
Affiliated Hospital of Hebei University
2022
Hebei University
2022
Taiyuan University of Science and Technology
2022
Third Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
National Clinical Research Center for Digestive Diseases
2021
Outer membrane vesicles (OMVs) are nanosized produced by the gut microbiota (GM). The GM is well-known to be involved in pathological process of Alzheimer's disease (AD). However, mechanism OMVs not clear. In present study, we demonstrated involvement development cognitive (learning and memory) dysfunction induced blood-brain barrier (BBB) disruption. More important, further study showed that tau phosphorylation activating glycogen synthase kinase 3β (GSK-3β) hippocampus. activated...
The role of mast cells (MCs) in colorectal cancer (CRC) remains unclear, and a comprehensive single-cell study on CRC MCs has not been conducted. This used multi-omics approach, integrating sequencing, spatial transcriptomics, bulk tissue sequencing data to investigate the heterogeneity impact CRC. Five MC signature genes (TPSAB1, TPSB2, CPA3, HPGDS, MS4A2) were identified, their average expression was as marker MCs. density found be lower compared normal tissue, but demonstrated distinct...
Carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9), 125 (CA125), and alpha-fetoprotein (AFP) are widely used tumor markers for colorectal cancer (CRC), but their clinical significance is unknown when the levels of these were within normal range. This retrospective study included 2145 CRC patients. The entire cohort was randomly divided into training validation datasets. optimal cut-off values calculated using X-tile software, univariate multivariate analyses performed to assess its...
SPP1+ macrophages have been identified as key players in the colorectal cancer (CRC) tumor microenvironment, but their function remains unclear. This study integrated single-cell and spatial transcriptomics with bulk sequencing to investigate roles mechanisms of CRC. Our findings revealed a pronounced elevation CRC, especially within territories. These served markers for CRC initiation, progression, metastasis, potential prognosis. Furthermore, they showed heightened transcriptional activity...
Metabolic reprogramming is a hallmark of cancer, which still far from being fully understood in colorectal cancer. In order to characterize the metabolic changes we performed metabolomics analysis paired colon tissues cancer patients by using liquid chromatography-mass spectrometry (LC-MS)-based method. Bioinformation was used define important metabolites and pathways, as well prognosis significance expression levels key molecules. The results indicated that metabolite phenotype cancerous...
Imatinib is highly effective in the treatment of chronic myelogenous leukemia (CML), but primary and acquired imatinib resistance remains big hurdle. Molecular mechanisms for CML to tyrosine kinase inhibitors, beyond point mutations BCR-ABL domain, still need be addressed. Here, we demonstrated that thioredoxin-interacting protein (TXNIP) a novel target gene. Suppression TXNIP was responsible triggered glucose metabolic reprogramming mitochondrial homeostasis. Mechanistically, Miz-1/P300...
This paper reports a new strategy for enhancing the photoresponse of quartz tuning fork (QTF). A deposited light absorbing layer on surface QTF could improve performance only to certain extent. Herein, novel is proposed construct Schottky junction QTF. The presented here consists silver-perovskite, which has extremely high absorption coefficient and dramatically power conversion efficiency. co-coupling perovskite's photoelectric effect its related thermoelastic leads dramatic improvement in...
Background The existing prognostic models of rectal cancer after radical resection ignored the relationships among factors and their mutual effects on prognosis. Thus, a new modeling method is required to remedy this defect. present study aimed construct prediction model based Bayesian network (BN), machine learning tool for data mining, clinical decision-making, prediction. Methods From January 2015 December 2017, 705 patients with who underwent were analyzed. entire cohort was divided into...
Berberine effectively alleviates non-alcoholic fatty liver disease (NAFLD). Nevertheless, the mechanism is incompletely comprehended. It has been reported that SIRT1 mediates lipid metabolism in and berberine promotes expression of hepatocytes. We hypothesized mediated effect on NAFLD.The effects NAFLD were evaluated C57BL/6J mice fed a high-fat diet (HFD) mouse primary hepatocytes cell lines exposed to palmitate. The change acid oxidation (FAO) activity CPT1A observed HepG2 cells....
The limited endogenous soluble phosphorus (P) in lake sediment is a potential and non-negligible P pool for the growth of Microcystis species bacteria attached to them. are considered as utilization supporters that contribute blooms; however, their effects on metabolism during poorly understood. Here, series cocultivations aeruginosa growth-promoting bacterium, Brucella sp., were conducted using two sources with solubility (tricalcium phosphate calcium phytate). results indicated sp....
Advancing flexible pressure sensors with high sensitivity and a wide measurement range presents major challenge development focus in the field. Although current sensing mechanisms can achieve sensitivity,...
Protein arginine methyltransferase 5 (PRMT5) is upregulated in multiple tumors and plays a pivotal role cancer cell proliferation. However, the of PRMT5 colorectal remains poorly understood. We detected expression level glycolytic enzymes using online databases lines by immunohistochemical staining, quantitative real-time polymerase chain reaction (qRT-PCR), western blotting. And MTT colony formation assays were conducted to investigate Then, we evaluated ECAR OCR levels biological energy...
The incidence of colorectal cancer (CRC) has remained high in recent years, and 5-fluorouracil (5-FU) is a vital chemotherapeutic agent for its treatment. Our previous study reported that N-myc downstream-regulated gene 4 (NDRG4) plays tumor-suppressive role CRC, but the mechanisms associated with NDRG4 5-FU chemosensitivity remain unclear. results present demonstrate sensitized CRC cells to by upregulating DNA damage inducible transcript 3 (DDIT3). inhibited proliferation activation...
Abstract Accumulating single-cell studies suggest that SPP1 + macrophages are key players in the tumor microenvironment. However, a systematic investigation of colorectal cancer (CRC) has not been conducted. A total eight RNA-seq datasets and 16 bulk were included this study. On basis existing research, we propose macrophage model paradigm, which can explain clinical features functional changes CRC better than M1/M2 polarization theory. We identified four subsets from myeloid cells: FCN1...
The torque is a significant indicator reflecting the comprehensive operational characteristics of power system. Thus, accurate measurement plays pivotal role in ensuring safety and stability However, conventional systems predominantly rely on strain gauges adhered to shaft, often leading reduced accuracy, poor repeatability, non-traceability due influence gauge adhesion. To tackle challenge, this paper introduces photoelectric Quadrants sensors are employed capture minute deformations...
Aiming to reveal the molecular mechanisms involved in right- and left-sided colorectal cancer (CRC) development, CRC gene expression data a microorganism atlas were downloaded from The Cancer Genome Atlas Microbiome Atlas, respectively. R package was used screen differentially expressed genes (DEGs) between samples identify those related prognosis, correlation analysis performed DEGs prognosis-related microbiota, an interaction network created using Cytoscape. Finally, taxon set enrichment...
In order to ensure the reliability and safety of complex engineering structures allow their redesign evaluation, estimation dynamic loads applied on them is vital. this paper, a novel time–frequency domain approach proposed identify random forces based weighted regularization algorithm. Firstly, Newmark’s algorithm was obtain structural responses, then weighed used exerted structure. The weighting matrix control identified error forces. A spatial frame model built illustrate practicality...