A5034164116- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Heavy metals in environment
- Fungal and yeast genetics research
- Plant Stress Responses and Tolerance
- Environmental Quality and Pollution
- Plant nutrient uptake and metabolism
- Hormonal and reproductive studies
- Colorectal Cancer Treatments and Studies
- Urological Disorders and Treatments
- Metabolism, Diabetes, and Cancer
- Odor and Emission Control Technologies
- Pancreatic and Hepatic Oncology Research
- Postharvest Quality and Shelf Life Management
- Plant Surface Properties and Treatments
- Seed Germination and Physiology
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Marine Biology and Environmental Chemistry
- Plant tissue culture and regeneration
- Higher Education and Teaching Methods
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- DNA Repair Mechanisms
- Cardiac Fibrosis and Remodeling
Guizhou Provincial People's Hospital
2020-2025
Southern Medical University
2025
Air Force Medical University
2023-2024
Xijing Hospital
2023-2024
Southwest University
2024
Xidian University
2023
Xi'an Medical University
2023
Lanzhou University
2019-2022
Hunan University
2017-2022
Beijing Friendship Hospital
2015-2022
Abstract Background Arsenic and cadmium are widely distributed in nature pose serious threats to the environment human health. Exposure these nonessential toxic metals may result a variety of diseases including cancer. However, arsenic toxicity targets cellular systems contributing tolerance acquisition not fully known. Results To gain insight into metal action mechanisms, we carried out genome-wide screening Saccharomyces cerevisiae haploid homozygous diploid deletion mutant collections...
The basic/helix–loop–helix (bHLH) transcription factor (TF) plays an important role for plant growth, development, and stress responses. Previously, proteomics of NaCl treated sugar beet leaves revealed that a bHLH TF, BvbHLH93, was significantly increased under salt stress. BvbHLH93 protein localized in the nucleus exhibited activation activity. expression up-regulated roots by stress, highest level 24 48 h after respectively. Furthermore, constitutive conferred enhanced tolerance...
Abstract Benign prostatic hyperplasia (BPH) is the most common and progressive urological disease in elderly men worldwide. Epidemiological studies have suggested that speed of progression varies among individuals, while pathophysiological mechanisms accelerated clinical some BPH patients remain to be elucidated. In this study, we defined with as belonging group (transurethral resection prostate [TURP] surgery at ≤50 years old), normal-speed (TURP ≥70 or non-progressive (age old without...
Carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9), 125 (CA125), and alpha-fetoprotein (AFP) are widely used tumor markers for colorectal cancer (CRC), but their clinical significance is unknown when the levels of these were within normal range. This retrospective study included 2145 CRC patients. The entire cohort was randomly divided into training validation datasets. optimal cut-off values calculated using X-tile software, univariate multivariate analyses performed to assess its...
The imbalance between estrogen and androgen may be an important mechanism of BPH, but the specific remains unclear. We used mixed sustained-release pellets made testosterone estradiol (T + E2) to stimulate establishment a BPH rat model. Compared prostate hyperplasia model using only androgens, new can observed have better macroscopic pathological characteristics hyperplasia. RNA-seq bioinformatics detect differentially expressed genes (DEGs) tissue novel benign prostatic group control group,...
C-C chemokine receptor type 2 (CCR2-) cardiac-resident macrophages (CCR2- cRMs) are known to promote cardiac repair after myocardial infarction (MI). However, the substantial depletion and slow recovery of CCR2- cRMs pose significant barriers in recovery. Here, we construct a functional conductive patch (CCP) that can provide exogenously elastic microenvironment induce endogenously reparative mediated by for MI repair. This CCP exhibits suitable mechanical properties, conductivity, high...
It recently became apparent that the highly conserved Snf1p protein kinase plays roles in controlling different cellular processes yeast Saccharomyces cerevisiae, addition to its well-known function glucose repression/derepression. We have previously reported together with Gis4p controls ion homeostasis by regulating expression of ENA1, which encodes Ena1p Na(+) extrusion system. In this study we found is rapidly phosphorylated when cells are exposed NaCl and phosphorylation required for...
The AMP-activated protein kinase, AMPK, controls energy homeostasis in eukaryotic cells but little is known about the mechanisms governing dynamics of its activation/deactivation. yeast SNF1, activated response to glucose depletion and mediates de-repression by inactivating transcriptional repressor Mig1. Here we show that overexpression Snf1-activating kinase Sak1 results, presence glucose, constitutive Snf1 activation without alleviating repression. Co-overexpression regulatory subunit...
Four types of soil (red, yellow, cinnamon, and paddy soil) from China were used to conduct experiments in pots study the influence humic acid (humic (HA) fulvic (FA)) on accumulation lead (Pb) cadmium (Cd) tobacco leaves.In non-polluted soils, leaf uptake Cd was dramatically influenced by total metal concentration properties, with no relationship observed for Pb.However, soils that polluted 500 mg kg -1 Pb or10 Cd, negative relationships between pH leaves.When Pb, application 4 g acids (HA...
Drought and heat stresses cause yield losses in alfalfa, a forage crop cultivated worldwide. Improving its drought tolerance is desirable for maintaining alfalfa productivity hot, arid regions. Cuticular wax forms protective barrier on aerial surfaces of land plants against environmental stresses. ABCG11 encodes an ATP binding cassette (ABC) transporter that functions the cuticular transport pathway. In this study, ZxABCG11 from xerophyte Zygophyllum xanthoxylum was introduced into by...
The aim of the present study was to observe effect stroma proportion in hyperplasia nodules on clinical symptoms benign prostatic (BPH) patients and identify different genes pathways between with epithelial-dominated (EDH) stromal-dominated (SDH) nodules.Sixty-seven BPH patient samples underwent transurethral resection prostate (TURP) were collected retrospectively analyzed. differences parameters EDH SDH groups investigated. Collagen fiber percentage assessed, correlation evaluated. mRNA...
ABSTRACT Gis4 is a new component of the system required for acquisition salt tolerance in Saccharomyces cerevisiae . The gis4 Δ mutant sensitive to Na + and Li ions but not osmotic stress. Genetic evidence suggests that mediates its function tolerance, at least partly, together with Snf1 protein kinase parallel calcineurin phosphatase. When exposed stress, mutants lacking display defect maintaining low intracellular levels exporting those from cell. This due diminished expression ENA1 gene,...
Late embryogenesis abundant (LEA) proteins are highly hydrophilic and thermostable that could be induced by abiotic stresses in plants. Previously, we have isolated a group 3 LEA gene WZY3-1 (GenBank: KX090360.1) wheat. In this study, the recombinant plasmid with was transformed into Escherichia coli BL21 for protein expression. Furthermore, Arabidopsis. Overexpression of E.coli enhanced their tolerance to mannitol NaCl. protect lactate dehydrogenase (LDH) under freeze heat stress. showed...
We conducted the present study to assess correlation of prostatic anatomical parameters, especially ratio peripheral zone thickness and transitional thickness, with clinical uroflowmetry characteristics suggestive benign prostate hyperplasia (BPH). A total 468 consecutive patients a detailed medical history were identified. All evaluated by scoring subjective symptoms International Prostate Symptom Score (IPSS) quality life (QoL). The parameters measured using transrectal ultrasonography,...