A5003658474- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Dermatology and Skin Diseases
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Gut microbiota and health
- Streptococcal Infections and Treatments
- Otitis Media and Relapsing Polychondritis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Musculoskeletal synovial abnormalities and treatments
- Autoimmune Bullous Skin Diseases
- Gastric Cancer Management and Outcomes
- Cutaneous lymphoproliferative disorders research
- Vestibular and auditory disorders
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Hearing, Cochlea, Tinnitus, Genetics
New York University
2014-2025
NYU Langone Health
2016-2023
Center for Rheumatology
2021-2022
New York University Langone Orthopedic Hospital
2020
Covid-19 in Immune-Mediated Inflammatory Diseases The authors describe patients New York City with known immune-mediated inflammatory disease whom developed while they were receiving...
To investigate the humoral and cellular immune response to messenger RNA (mRNA) COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.
To evaluate seroreactivity and disease flares after COVID-19 vaccination in a multiethnic/multiracial cohort of patients with systemic lupus erythematosus (SLE). Ninety SLE 20 healthy controls receiving complete vaccine regimen were included. IgG to the SARS-CoV-2 spike receptor-binding domain (RBD) microneutralization used B cell responses; interferon-γ (IFNγ) production was measured by enzyme-linked immunospot (ELISpot) assay order assess T responses. Disease activity hybrid Activity Index...
Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context systemic impact remain poorly understood. We thus profiled psoriasis (PsO) as a prototypic immune-mediated condition with high predilection for extracutaneous involvement. Spatial transcriptomics (ST) analyses 25 healthy, active lesion, clinically uninvolved biopsies integration public single-cell data revealed marked differences in immune microniches between healthy...
Objective To characterize the hospitalization and death rates among patients with inflammatory arthritis (IA) affected by coronavirus disease 2019 (COVID-19) to analyze associations of comorbidities immunomodulatory medications infection outcomes. Methods Data on clinical demographic features, maintenance treatment, course, outcomes in individuals IA (rheumatoid spondyloarthritis) symptomatic COVID-19 were prospectively assessed via web-based questionnaire followed individual phone calls...
Objective To characterize patients with systemic lupus erythematosus (SLE) affected by coronavirus disease 2019 (COVID‐19) and to analyze associations of comorbidities medications on infection outcomes. Methods Patients SLE reverse transcriptase–polymerase chain reaction–confirmed COVID‐19 were identified through an established New York University cohort, query 2 hospital systems, referrals from rheumatologists. Data prospectively collected via a web‐based questionnaire review medical...
To investigate the cutaneous microbiome spanning entire psoriatic disease spectrum, and to evaluate distinguishing features of psoriasis (PsO) arthritis (PsA).
Introduction Psoriatic arthritis (PsA) is a complex, immune-mediated disease associated with skin psoriasis that, if left untreated, can lead to joint destruction. Up 30% of patients progress PsA. In most cases, precedes synovio-entheseal inflammation by an average 5–7 years, providing unique opportunity for early and potentially preventive intervention in susceptible identifiable population. Guselkumab effective IL-23p19 inhibitor Food Drug Administration (FDA)-approved treatment...
Despite significant therapeutic advances in psoriatic arthritis (PsA), many patients do not achieve remission and cycle through multiple biologic (b)- or targeted synthetic (ts)- DMARDs. Identifying the underlying reasons for repetitive failure remains a knowledge gap. Here we describe prescribing patterns characteristics of PsA with multi-b/tsDMARD at NYU Psoriatic Arthritis Center. Nine hundred sixty were enrolled an observational, longitudinal registry. Demographics, medical history,...
To investigate the humoral and cellular immune response to mRNA COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.Established at NYU Langone Health IMID (n=51) receiving BNT162b2 vaccination were assessed baseline after second immunization. Healthy subjects served as controls (n=26). IgG antibody responses spike protein analyzed for response. Cellular SARS-CoV-2 was further using high-parameter spectral flow cytometry. A...
Psoriatic disease remains underdiagnosed and undertreated. We developed validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous musculoskeletal signs symptoms psoriatic disease. Participants with psoriasis (PsO) or arthritis (PsA) healthy controls were recruited between June 5, 2019, November 10, 2021, at 2 academic medical centers. Concordance accuracy digital measures image-based machine learning models compared...
Abstract Objectives Autoantibody seroconversion has been extensively studied in the context of COVID-19 infection but data regarding post-vaccination autoantibody production is lacking. Here we aimed to determine incidence common formation following mRNA vaccines patients with inflammatory arthritis (IA) and healthy controls. Methods was measured by serum ELISA a longitudinal cohort IA participants controls before after mRNA-based immunization. Results Overall, there significantly lower ANA...
Abstract Objective Individuals of racially and ethnically diverse backgrounds are underrepresented in PsA research/clinical trials, despite evidence that their disease presentation, severity course may be distinct. Here we aim to describe how race, ethnicity other socioeconomic factors inform characteristics PsA. Methods A total 817 consecutive patients with from a large, metropolitan area were enrolled an observational, longitudinal registry. Demographics, medical history, medication use...
Psoriatic arthritis (PsA) is a chronic, inflammatory that, when left untreated, can lead to erosions, deformities and decrease in quality of life. PsA known be associated with multiple comorbidities, including cardiovascular, metabolic mental health syndromes, all which increase its overall morbidity mortality.