A5043550255- Inflammatory Myopathies and Dermatomyositis
- Psoriasis: Treatment and Pathogenesis
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- COVID-19 Clinical Research Studies
- Spondyloarthritis Studies and Treatments
- SARS-CoV-2 and COVID-19 Research
- Dermatology and Skin Diseases
- Rheumatoid Arthritis Research and Therapies
- Cancer Immunotherapy and Biomarkers
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Long-Term Effects of COVID-19
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Otitis Media and Relapsing Polychondritis
- Autoimmune and Inflammatory Disorders Research
- Complement system in diseases
- Autoimmune Bullous Skin Diseases
- Celiac Disease Research and Management
- Diabetes and associated disorders
- Heterotopic Ossification and Related Conditions
- Genetic Syndromes and Imprinting
Brigham and Women's Hospital
2023-2025
Harvard University
2023-2025
Boston Children's Hospital
2023-2024
New York University
2020-2024
NYU Langone Health
2021-2024
Center for Rheumatology
2020-2022
New York University Langone Orthopedic Hospital
2020
Philippine General Hospital
2019
University of Connecticut
2017
Hospital General Universitario Gregorio Marañón
2001
Covid-19 in Immune-Mediated Inflammatory Diseases The authors describe patients New York City with known immune-mediated inflammatory disease whom developed while they were receiving...
To investigate the humoral and cellular immune response to messenger RNA (mRNA) COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.
Whereas the cellular and molecular features of human inflammatory skin diseases are well characterized, their tissue context systemic impact remain poorly understood. We thus profiled psoriasis (PsO) as a prototypic immune-mediated condition with high predilection for extracutaneous involvement. Spatial transcriptomics (ST) analyses 25 healthy, active lesion, clinically uninvolved biopsies integration public single-cell data revealed marked differences in immune microniches between healthy...
Objective To characterize the hospitalization and death rates among patients with inflammatory arthritis (IA) affected by coronavirus disease 2019 (COVID-19) to analyze associations of comorbidities immunomodulatory medications infection outcomes. Methods Data on clinical demographic features, maintenance treatment, course, outcomes in individuals IA (rheumatoid spondyloarthritis) symptomatic COVID-19 were prospectively assessed via web-based questionnaire followed individual phone calls...
Objective To characterize patients with systemic lupus erythematosus (SLE) affected by coronavirus disease 2019 (COVID‐19) and to analyze associations of comorbidities medications on infection outcomes. Methods Patients SLE reverse transcriptase–polymerase chain reaction–confirmed COVID‐19 were identified through an established New York University cohort, query 2 hospital systems, referrals from rheumatologists. Data prospectively collected via a web‐based questionnaire review medical...
Introduction Psoriatic arthritis (PsA) is a complex, immune-mediated disease associated with skin psoriasis that, if left untreated, can lead to joint destruction. Up 30% of patients progress PsA. In most cases, precedes synovio-entheseal inflammation by an average 5–7 years, providing unique opportunity for early and potentially preventive intervention in susceptible identifiable population. Guselkumab effective IL-23p19 inhibitor Food Drug Administration (FDA)-approved treatment...
We describe radiologic and symptomatic improvement in two dermatomyositis patients with recalcitrant muscle disease following off-label treatment anifrolumab, a monoclonal antibody targeting type I IFN receptor recently approved by the FDA EMA for of systemic lupus erythematosus.
Adult-onset dermatomyositis (DM) is an autoimmune inflammatory myopathy with distinct cutaneous manifestations and a strong malignancy association. Through comparative analysis lupus erythematosus (CLE), our integrated spatial single-cell transcriptomics revealed unique immune stromal niches associated DM subtypes. Unexpectedly, we found association between cancer-associated skin lesions the presence of dispersed infiltrates enriched macrophages, CD8+ T cells, plasma B cells preserved...
To investigate the humoral and cellular immune response to mRNA COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunomodulatory treatment.Established at NYU Langone Health IMID (n=51) receiving BNT162b2 vaccination were assessed baseline after second immunization. Healthy subjects served as controls (n=26). IgG antibody responses spike protein analyzed for response. Cellular SARS-CoV-2 was further using high-parameter spectral flow cytometry. A...
This cohort study examines the association between methotrexate use and interstitial lung disease in patients with dermatomyositis.
Psoriatic disease remains underdiagnosed and undertreated. We developed validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous musculoskeletal signs symptoms psoriatic disease. Participants with psoriasis (PsO) or arthritis (PsA) healthy controls were recruited between June 5, 2019, November 10, 2021, at 2 academic medical centers. Concordance accuracy digital measures image-based machine learning models compared...
Abstract Objectives Autoantibody seroconversion has been extensively studied in the context of COVID-19 infection but data regarding post-vaccination autoantibody production is lacking. Here we aimed to determine incidence common formation following mRNA vaccines patients with inflammatory arthritis (IA) and healthy controls. Methods was measured by serum ELISA a longitudinal cohort IA participants controls before after mRNA-based immunization. Results Overall, there significantly lower ANA...
ABSTRACT Dermatomyositis (DM) and alopecia areata are two diseases characterised by aberrant interferon signalling. While patchy of the scalp is a known feature DM, universalis, which involves hair loss over entire body, has rarely been reported in conjunction with DM. Herein, we report case 30-year-old female DM who developed refractory cutaneous disease universalis that were successfully treated tofacitinib. This could suggest concomitant severe may reflect strong baseline gene signature...
Abstract Background Psoriasis and psoriatic arthritis are common immune-mediated inflammatory conditions that primarily affect the skin, joints entheses can lead to significant disability worsening quality of life. Although early recognition treatment prevent development permanent damage, disease remains underdiagnosed undertreated due in part disparity between prevalence relative lack access clinical specialists dermatology rheumatology. Remote patient self-assessment aided by smartphone...
Immune checkpoint inhibitors (ICIs) are a class of medications targeting mostly the PD-1/PD-L1 and CTLA-4 immune pathways in treatment many cancers. Despite encouraging success ICIs, they associated with immune-related adverse events as well exacerbation underlying autoimmune conditions. The these conditions often involves discontinuation ICI addition to utilization immunomodulatory agents. In this report, we discuss case which patient metastatic renal cell carcinoma experienced...