A5015257895- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Psoriasis: Treatment and Pathogenesis
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Antifungal resistance and susceptibility
- Immunotherapy and Immune Responses
- Inflammatory Myopathies and Dermatomyositis
- Phagocytosis and Immune Regulation
- Whipple's Disease and Interleukins
- Chronic Myeloid Leukemia Treatments
- Fungal Infections and Studies
- Reconstructive Facial Surgery Techniques
- Neuroendocrine Tumor Research Advances
- Acute Lymphoblastic Leukemia research
- Nonmelanoma Skin Cancer Studies
- Endoplasmic Reticulum Stress and Disease
- NF-κB Signaling Pathways
- Systemic Lupus Erythematosus Research
- Galectins and Cancer Biology
Brigham and Women's Hospital
2015-2025
Harvard University
2007-2025
Broad Institute
2019
Harvard Affiliated Emergency Medicine Residency
2016-2017
Massachusetts General Hospital
2009-2015
University at Buffalo, State University of New York
2008-2013
University of Pittsburgh
2009-2013
Center for Rheumatology
2010
Dana-Farber Cancer Institute
2005-2009
University of Dental Medicine
2009
The commensal fungus Candida albicans causes oropharyngeal candidiasis (OPC; thrush) in settings of immunodeficiency. Although disseminated, vaginal, and oral are all caused by C. species, host defense against varies anatomical location. T helper 1 (Th1) cells have long been implicated candidiasis, whereas the role Th17 remains controversial. IL-17 mediates inflammatory pathology a gastric model mucosal but is protective disseminated disease. Here, we directly compared Th1 function OPC....
IL-17 mediates essential inflammatory responses in host defense and autoimmunity. The IL-17A-IL-17F signaling complex is composed of IL-17RA IL-17RC, both which are necessary for signal transduction. To date, the specific contribution IL-17RC to downstream remains poorly understood. define regions within cytoplasmic tail required transduction, we assayed by a panel deletion mutants. These findings reveal that inducibly associates with glycosylated isoform, manner independent tail. Using...
Abstract The existence of X‐linked disorders in humans has been recognized for many centuries, based on lessons religious texts and observations specific human families (e.g., color blindness or Daltonism). Our modern concepts Mendelian (including X‐linked) inheritance originated just after the turn last century. Early dominance recessiveness were first used conjunction with autosomal traits, then applied to “sex”‐linked traits distinguish recessive dominant inheritance. former was defined...
Tim-1, a phosphatidylserine receptor expressed on B cells, induces interleukin 10 (IL-10) production by sensing apoptotic cells. Here we show that mice with cell-specific Tim-1 deletion develop tissue inflammation in multiple organs including spontaneous paralysis the central nervous system (CNS). Transcriptomic analysis demonstrates besides IL-10, Tim-1+ cells also differentially express number of co-inhibitory checkpoint receptors TIGIT. Mice TIGIT CNS inflammation, but limited other...
We describe radiologic and symptomatic improvement in two dermatomyositis patients with recalcitrant muscle disease following off-label treatment anifrolumab, a monoclonal antibody targeting type I IFN receptor recently approved by the FDA EMA for of systemic lupus erythematosus.
Abstract Background/Objectives Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are medical emergencies. Mainstays of treatment include removal the offending agent, supportive care, wound care. The use immunosuppressive agents such as corticosteroids intravenous immunoglobulin (IVIg) is controversial. Some case reports small studies report successful cyclosporin A (CsA) for SJS/TEN in halting disease progression, fostering reepithelialization, reducing mortality. Objective...
IL-17, the hallmark cytokine of Th17 population, mediates immunity to extracellular pathogens and promotes autoimmune immunopathology. The signaling mechanisms triggered by IL-17 receptor (IL-17RA) related receptors are strikingly different from other subclasses. Namely, IL-17Rs contain a conserved SEF/IL-17R (SEFIR) subdomain that engages Act1, leading activation TRAF6, NF-κB, events. Although SEFIR is critical for signaling, molecular details functional subdomains within IL-17RA remain...
Abstract While a familial predisposition may exist in up to 20% of patients with Waldenström's Macroglobulinemia (WM), the precipitating cause this B‐cell malignancy remains unknown most patients. In previous studies, an association between hepatitis C virus (HCV) infection and WM has been suggested as etiological. This relationship subject debate, however, some studies demonstrating increased incidence HCV among other showing no such exists. discordance might be attributable analytical...
IL-17 is the founding member of a family cytokines and receptors with unique structures signaling properties. signature cytokine Th17 cells, relatively new T cell population that promotes inflammation in settings infection autoimmunity. Despite advances understanding mechanisms IL-17-mediated signal transduction are less well defined. requires contributions from two receptor subunits, IL-17RA IL-17RC. Mutants IL-17RC lacking cytoplasmic domain nonfunctional, indicating provides essential but...
Summary Waldenstrom Macroglobulinemia (WM) is a B‐cell malignancy characterized by excess bone marrow (BM) lymphoplasmacytic cells (LPC). The accumulation of LPC in WM may represent failure B‐cells to properly differentiate into plasma cells. present study investigated transcriptional expression genes involved late differentiation, including PRDM1 , PAX5 XBP1 transcripts and ERN1, BM from 31 patients with six healthy donors. Real time reverse transcription polymerase chain reaction (RT‐PCR)...
Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis that has been reported in association with certain medications. Recognition of medications trigger PG may help to better understand the pathogenesis condition and provide earlier diagnosis treatment for affected patients. Herein, we report case new-onset following initiation checkpoint inhibitor pembrolizumab metastatic cutaneous squamous cell carcinoma. Our was resistant intralesional corticosteroid therapy, but...
This case report describes 3 patients with systemic sclerosis or mixed connective tissue disease scleroderma features who experienced salt-and-pepper dyspigmentation that responded to treatment mycophenolate mofetil.