A5062200109- Chronic Lymphocytic Leukemia Research
- Genetic Neurodegenerative Diseases
- Monoclonal and Polyclonal Antibodies Research
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Neurological disorders and treatments
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Chemokine receptors and signaling
- Suicide and Self-Harm Studies
- Metabolism, Diabetes, and Cancer
- Radiomics and Machine Learning in Medical Imaging
- Multiple Sclerosis Research Studies
- Phagocytosis and Immune Regulation
- Gun Ownership and Violence Research
- Migraine and Headache Studies
- Genetic Syndromes and Imprinting
- Clinical practice guidelines implementation
- Galectins and Cancer Biology
- Trigeminal Neuralgia and Treatments
- Restraint-Related Deaths
- Prenatal Substance Exposure Effects
- Obsessive-Compulsive Spectrum Disorders
National Hospital for Neurology and Neurosurgery
2022-2025
University College London
2022-2025
Huntington's Disease Association
2023-2025
Dana-Farber Cancer Institute
2007-2023
McGill University
2012-2023
Harvard University
2007-2023
Guy's and St Thomas' NHS Foundation Trust
2022-2023
American University of Antigua
2023
King's College Hospital
2022
King's College Hospital NHS Foundation Trust
2021-2022
Abstract Genome-wide demethylation and remethylation of DNA during early embryogenesis is essential for development. Imprinted germline differentially methylated domains (gDMDs) established by sex-specific methylation in either male or female germ cells, must escape these dynamic changes sustain precise inheritance both unmethylated parental alleles. To identify other, gDMD-like sequences with the same epigenetic properties, we used a modified embryonic stem (ES) cell line that emulates...
Pharmacological treatments for Tourette syndrome (TS) vary in efficacy between different patients. The evidence base is limited as even high quality controlled studies tend to be of relatively short duration which may lose relevance clinical usage. Patients are frequently treated with serial agents the search and tolerability. success this strategy has not been previously documented. We examined 400 consecutive TS patients seen over a 10-year period, some longer prior history other clinics;...
Assisted reproductive technologies (ART) account for 1-6% of births in developed countries. While most children conceived are healthy, increases birth and genomic imprinting defects have been reported; such abnormal outcomes attributed to underlying parental infertility and/or the ART used. Here, we assessed whether paternal genetic lifestyle factors, that associated with male affect sperm epigenome, can influence outcomes. We examined how haploinsufficiency Dnmt3L, an important co-factor...
Abstract Purpose: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma characterized by widespread involvement of the bone marrow. Despite different options therapy, still incurable. Src tyrosine kinase has been shown to play central role in regulation variety biological processes, such as cell proliferation, migration, adhesion, and survival solid tumors. We sought determine whether protein regulates macroglobulinemia. Experimental Design: tested expression normal cells, effect...
Abstract Background Clinically assisted nutrition and hydration via percutaneous endoscopic gastrostomy (PEG) is a therapeutic option to ameliorate the difficulties associated with enhanced catabolism, weight loss, dysphagia in Huntington's disease (HD). Objectives The objective provide insights into demographics, staging (Shoulson‐Fahn), complications, trajectories, survival rates people HD (pwHD) who underwent PEG. Methods This retrospective study included 705 consecutive pwHD attended our...
Indomethacin-responsive headaches encompass a group of disorders which include subset the trigeminal autonomic cephalalgias and other paroxysmal, often precipitated primary headaches. Many patients show rapid therapeutic response to indomethacin, is limited by intolerability. Etoricoxib celecoxib, selective inhibitors cyclo-oxygenase-2 (COX-2), spare gastroduodenal COX-1 activity are less likely cause gastrointestinal adverse effects than indomethacin. We report case series eight patients,...
This is the first study to ascertain value of multidisciplinary team (MDT) meetings within an early pregnancy assessment unit (EPAU). Our national telephone survey identified that in United Kingdom, overall 37% EPAU utilise regular MDT meetings. Secondary and tertiary hospitals are just as likely hold The participants our interview expressed principal benefits communication, education effective stress management. perceived additional included improved care quality, better patient experience...
This study compared the past-year prevalence rates of nonsuicidal self-injury produced by a behavioral checklist assessment and single-item measure. In order to extend previous research on differences in across samples, we employed both types within single sample young adults (N = 433). Moreover, as an indicator convergent validity, those were analyzed association with participants' depression anxiety scores. Findings indicated that assessment, relative measure, substantially higher rate,...
Advance care planning (ACP) is a useful tool that benefits adult patients, providers, and surrogate decision makers, through providing opportunities for patients to consider, express, formalize their beliefs, preferences, wishes pertaining decisions regarding future medical at time when they retain decision-making capacity. Early timely consideration of ACP discussions paramount in Huntington's disease (HD) given the potential challenges ascertaining capacity advanced stages disease. helps...
Chorea can be associated with autoimmune diseases such as antiphospholipid syndrome and has been the isolated presence of antibodies (aPL). is a rare neurological manifestation syndrome. The pathophysiological mechanisms underlying aPL-related chorea are still debated. One postulated mechanism aPL or other autoantibody binding to brain-blood vessel endothelium, resulting in endothelial dysfunction secondary proinflammatory cascade, sequalae inflammation local microthrombosis. Another...