A5100750959- Hedgehog Signaling Pathway Studies
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Genetic and Kidney Cyst Diseases
- Sperm and Testicular Function
- Genomic variations and chromosomal abnormalities
- Cancer Cells and Metastasis
- Urological Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
Stanford University
2014-2018
Philips (Netherlands)
2018
California Institute for Regenerative Medicine
2015
Howard Hughes Medical Institute
2014
Duke University
2009
The stem cell niche is a complex local signaling microenvironment that sustains activity during organ maintenance and regeneration. mammary gland must support its associated cells while also responding to systemic hormonal regulation triggers pubertal changes. We find Gli2, the major Hedgehog pathway transcriptional effector, acts within mouse stromal direct hormone-responsive program by activating expression of factors regulate epithelial as well receptors for mammatrophic hormones estrogen...
Binding of the Hedgehog (Hh) protein signal to its receptor, Patched, induces accumulation seven-pass transmembrane Smoothened (Smo) within primary cilium and zinc finger transcription factor Gli2 at ciliary tip, resulting ultimately in Gli-mediated changes nuclear gene expression. However, mechanism by which pathway activation is communicated from Smo not known. In an effort elucidate this mechanism, we identified Dlg5 (Discs large, homolog 5) a biochemical screen for proteins that...
Abstract We reported that transcriptional regulation by the major Hedgehog (HH) pathway effector GLI2 in mammary gland stromal cells coordinates a hormone-responsive niche signaling program directs epithelial stem cell activity during puberty [Zhao, et al., Science. 2017 Apr 21;356(6335)]. HH is key growth human carcinogenesis. The first targeted therapies aimed at G-protein coupled receptor Smoothened (SMO) resulted rapid acquired resistance, underscoring need for developing new...