A5004302536- Circadian rhythm and melatonin
- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Dietary Effects on Health
- Viral-associated cancers and disorders
- Testicular diseases and treatments
- Cancer and Skin Lesions
- Reproductive System and Pregnancy
- Spaceflight effects on biology
- Ovarian cancer diagnosis and treatment
- CNS Lymphoma Diagnosis and Treatment
- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Diet and metabolism studies
- Tumors and Oncological Cases
- Immune Cell Function and Interaction
- Blood Pressure and Hypertension Studies
- Acute Myeloid Leukemia Research
- Soft tissue tumor case studies
- Uterine Myomas and Treatments
- Pluripotent Stem Cells Research
- Sirtuins and Resveratrol in Medicine
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Health, Environment, Cognitive Aging
Carol Davila University of Medicine and Pharmacy
2011-2024
Hôpital Civil, Strasbourg
2024
Hôpital d'Hautepierre
2019-2023
Center for Cancer Research
2013-2018
National Cancer Institute
2013-2018
National Institutes of Health
2014-2018
University of Bern
2016-2017
Cancer Institute (WIA)
2013
Instituto de Investigación Biosanitaria de Granada
2011-2012
Universidad de Granada
2009-2011
Abstract Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing 68 HSTLs, we define recurrently mutated driver genes copy-number alterations in disease. Chromatin-modifying genes, including SETD2, INO80, ARID1B, were commonly HSTL, affecting 62% cases. HSTLs manifest frequent mutations STAT5B (31%), STAT3 (9%), PIK3CD for which there currently exist potential targeted therapies. In addition, noted...
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but molecular mechanisms are incompletely understood. We now show that loss permits sustained proliferation primary murine endothelial cells, increases asymmetric division enables these cells to spontaneously reprogram form multipotent embryoid body-like clusters. c-Myc, Klf4, Oct4 Sox2 expression is elevated in CD47-null several tissues CD47- thrombospondin-1-null mice a human T line...
Induced pluripotent stem cell (iPSC)-based therapies have great potential for regenerative medicine but are also potentially associated with tumorigenic risks. Current rodent models not optimal predictors of efficiency and safety clinical application. Therefore, we developed a clinically relevant nonhuman primate model to assess the in vivo efficacy both undifferentiated differentiated iPSCs autologous settings without immunosuppression. Undifferentiated indeed form mature teratomas...
Surgical site infections (SSIs) determine an increase in hospitalization time and antibiotic therapy costs. The aim of this study was to identify the germs involved SSIs patients from Clinical Emergency County Hospital Craiova (SCJUC) assess their resistance antimicrobials, with comparisons between surgical wards intensive care unit (ICU). biological samples were subjected classical bacteriological diagnostics. Antibiotic tested by disc diffusion. We used hierarchical clustering as a method...
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and classical (CHL) are classified separately because of their distinct clinical pathologic features. Whereas Epstein-Barr virus (EBV) is detected in the neoplastic cells 25% to 70% CHL, NLPHL generally considered be EBV(-). We assessed EBV status 302 pediatric adult cases NLPHL. A total 145 (age 18 y or younger) 157 were retrieved from 3 North American centers tested for by situ hybridization (EBV-encoded small RNA). Clinical features...
Aggressive natural killer cell leukemia (ANKL) is a systemic NK-cell neoplasm, almost always associated with Epstein-Barr virus (EBV). Rare cases of EBV-negative ANKL have been described, and some reports suggested more indolent behavior. We report the clinicopathologic, immunophenotypic, molecular characteristics 7 ANKL. All patients were adults, median age 63 years (range 22 to 83 y) an M:F ratio 2.5:1. Five White, 1 Black, Asian. presented acutely, fever (6/7), cytopenias splenomegaly...
Induced pluripotent stem cell (iPSC) therapies offer a promising path for patient-specific regenerative medicine. However, tumor formation from residual undifferentiated iPSC or transformation of their derivatives is risk. Inclusion suicide gene one approach to risk mitigation. We introduced dimerizable-"inducible caspase-9" (iCasp9) into mouse (miPSC) and rhesus (RhiPSC) via lentivirus, driving expression either cytomegalovirus (CMV), elongation factor-1 α (EF1α) pluripotency-specific...
Primary central nervous system (CNS) lymphomas are relatively rare with the most common subtype being diffuse large B-cell lymphoma. CNS T-cell (PCNSTL) account for <5% of lymphomas. We report clinical, morphologic, immunophenotypic, and molecular characteristics 18 PCNSTLs. Fifteen cases were classified as peripheral lymphoma, not otherwise specified, 2 which γδ derivation 1 was TCR silent; there anaplastic cell ALK-positive ALK-negative. Median age 58.5 years (range, 21 to 81 y), an M:F...
Cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases were discussed at the 2022 European Association for Haematopathology/Society Hematopathology lymphoma workshop held in Florence, Italy. This session focused on (i) primary nodal T NK-cell (primary nodal-EBV-TNKL), (ii) extranodal T/NK (LPD) children adults, (iii) cytotoxic lymphomas, NOS (cPTCL-NOS), EBV-negative, (iv) miscellaneous cases. Primary nodal-EBV-TNKL is a newly recognized entity which...
In the new therapeutic era, disease-modifying treatment (nusinersen) has changed natural evolution of spinal muscular atrophy (SMA), creating phenotypes. The main purpose retrospective observational study was to explore changes in clinical and electrophysiological data after 2 years nusinersen treatment. We assessed distal compound motor action potential (CMAP) on ulnar nerve abilities 34 SMA patients, aged between 1 16 old, under treatment, using specific scales for types 1, 3. evaluations...
Background and Objectives: Polypharmacy is associated with drug-drug or food-drug interactions that may pose treatment difficulties. The objective of the study was to investigate use polypharmacy in hypertensive patients hospitalized Internal Medicine Clinic a European referral hospital. Materials Methods: We conducted retrospective chart review on identified by database search discharge diagnoses assess identify potential interactions. Results: In total, 166 (68.46 ± 12.70 years, range...
Cutaneous metastases from signet ring cell gastric carcinoma are uncommon. A 69-year-old man presented with a 15-day history of an asymptomatic indurated scar-like lesion. The biopsy revealed infiltrating consistent metastasis. Gastroscopy and showed cells; subsequent computed tomography metastatic nodules in the liver, mesentery, retroperitoneal peripancreatic lymph nodes. review 10 cases cutaneous metastasis literature that origin usually appear at earlier ages than our patient primary...
Clear cell papillary cystadenoma (CCPC) is associated with von Hippel-Lindau disease (VHLD), but rarely involves mesosalpinx and broad ligament (M/BL). This study provides new data about its behaviour immunophenotype.We performed an analysis of four benign cases CCPC M/BL either characteristic clinical features or genetic markers [loss heterozygosity (LOH)] VHLD in patients ranging from 24 to 36 years a sporadic case 52-year-old presenting peritoneal metastases. All CCPCs were had solid...