A5103210776- Neonatal and fetal brain pathology
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Adipose Tissue and Metabolism
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Anesthesia and Sedative Agents
- Aldose Reductase and Taurine
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
- Neural dynamics and brain function
- Hormonal and reproductive studies
- Neurological Disease Mechanisms and Treatments
- Fatty Acid Research and Health
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Stress Responses and Cortisol
- Motivation and Self-Concept in Sports
- Pain Management and Placebo Effect
- Bariatric Surgery and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
Carol Davila University of Medicine and Pharmacy
2014-2024
University of Bucharest
2022
Children's Hospital of Philadelphia
2019
University of Pennsylvania
2019
We describe here - presumably for the first time-a Cajal-like type of tubal interstitial cells (t-ICC), resembling archetypal enteric ICC. t-ICC were demonstrated in situ and vitro on fresh preparations (tissue cryosections primary cell cultures) using methylene-blue, crystal-violet, Janus-Green B or Mito Tracker-Green FM Probe vital stainings. Also, identified fixed specimens by light microscopy (methylene-blue, Giemsa, trichrome stainings, Gomori silver-impregnation) transmission electron...
Supraphysiological administration of anabolic androgenic steroids has been linked to increased blood pressure. The widely distributed amino acid taurine seems be an effective depressor agent in drug-induced hypertension. purpose this study was assess the impact chronic high dose nandrolone decanoate (DECA) and on pressure rats verify potentially involved mechanisms. conducted 4 groups 8 adult male Wistar rats, aged 14 weeks, treated for 12 weeks with: DECA (A group); vehicle (C (T group), or...
The role of nonapeptides in the modulation sleep has been described by several studies; yet, little evidence is found on effects oxytocin (OT), a nonapetide involved human social behaviour and regulation hypothalamo-pituitary-adrenal axis. aim present study to examine whether intranasal administration OT any effect architecture. Ten healthy male volunteers were included double-blind, cross-over randomly administered nasal instillations either placebo or OT. A one-month washout period was...
This study presents an improved method for obtaining spheroids microwell arrays histological processing and analysis, focusing on glioblastoma (U87 MG) breast adenocarcinoma (MCF-7) tumor models. By transitioning from traditional 2D cell cultures to 3D systems, this approach overcomes the limitations of by more accurately replicating microenvironment. The consists producing homotypic heterotypic using low-adherence agarose-coated wells, embedding these in agarose arrays, conducting...
Anabolic androgenic steroids (AAS) are synthetic derivatives of testosterone with thrombogenic potential in high doses and long-term administration. Taurine, a widely distributed amino-sulfonic acid, is known for its beneficial effects hypercoagulable states. In order to assess the impact chronic administration AAS taurine upon haemostasis process rats, 40 male Wistar rats were divided into four equal groups: control group (group C) - no treatment; androgen A) received 10 mg/kg per week...
<b><i>Background:</i></b> High-fat diet (HFD) is a detrimental habit with harmful systemic consequences, including low-grade, long-lasting inflammation. During pregnancy, HFD can induce developmental changes. Moreover, HFD-related maternal obesity might enhance the risk of peripartum complications hypoxic-ischemic encephalopathy secondary to perinatal asphyxia (PA). <b><i>Objectives:</i></b> Following our previous results showing that PA...
Citicoline represents a dietary source of choline, an essential nutrient, and precursor cell membrane components, highly required during development post-injury recovery.We previously showed that perinatal asphyxia (PA) induces hippocampal neuroinflammation injury are subject to epigenetic change by maternal diet. The present study investigates citicoline-supplemented diet (CSD) impact on offspring response PA.Six-day-old Wistar rats from mothers with standard-diet or CSD were exposed PA....
The role of the claustrum in consciousness and vigilance states was proposed more than two decades ago; however, its anesthesia is not yet understood, this requires investigation. aim our study to assess impact electrical stimulation during isoflurane adult rats. left hemisphere electrically stimulated using a bipolar tungsten electrode inserted stereotaxically. In order monitor anesthetic depth, electrocorticogram (ECoG) recorded before, during, after frontal parietal epidural electrodes...
Neuronal ischemia results in chloride gradient alterations which impact the excitatory-inhibitory balance, volume regulation, and neuronal survival. Thus, Na+/K+/Cl- co-transporter (NKCC1), K+/ Cl- (KCC2), gamma-aminobutyric acid A (GABAA) receptor may represent therapeutic targets stroke, but a time-dependent effect on viability could influence outcome. We, therefore, successively blocked NKCC1, KCC2, GABAA (with bumetanide, DIOA, gabazine, respectively) or activated isoguvacine) either...
Motor coordination and motor learning are well-known roles of the cerebellum. Recent evidence also supports contribution cerebellum to oscillatory activity brain networks involved in a wide range disorders. Kainate, potent analog excitatory neurotransmitter glutamate, can be used induce dystonia, neurological movement disorder syndrome consisting sustained or repetitive involuntary muscle contractions, when applied on surface This research aims study interhemispheric cortical communication...
Background: Anesthetic preconditioning (AP) is known to mimic ischemic preconditioning. The purpose of this study was investigate the effects an interrupted sevoflurane administration protocol on myocardial ischemia/reperfusion (I/R) injury. Methods: Male Wistar rats (n = 60) were ventilated for 30 min with room air (control group, CG) or a mixture and (1 minimum alveolar concentration—MAC) in 5-min cycles, alternating wash-out periods (preconditioned groups). Cytokines implicated AP...