A5086297495- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Marine animal studies overview
- Animal Vocal Communication and Behavior
- Animal Behavior and Reproduction
- Genetic Neurodegenerative Diseases
- Vestibular and auditory disorders
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Anesthesia and Sedative Agents
- Neuroscience and Neural Engineering
- Neurobiology and Insect Physiology Research
- Pancreatic function and diabetes
- Neuroscience of respiration and sleep
- Animal Behavior and Welfare Studies
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Axon Guidance and Neuronal Signaling
- Ocular Surface and Contact Lens
Universitat Autònoma de Barcelona
2019-2024
Inserm
2017-2022
Institut de Biologie de l'École Normale Supérieure
2015-2022
Université Paris Sciences et Lettres
2017-2022
Centre National de la Recherche Scientifique
2014-2022
École Normale Supérieure - PSL
2018
Université Paris-Sud
2015
Institut des Neurosciences Paris-Saclay
2015
Gènes, synapses et cognition
2012
Mitochondrial deficits in energy production cause untreatable and fatal pathologies known as mitochondrial disease (MD). Central nervous system affectation is critical Leigh Syndrome (LS), a common MD presentation, leading to motor respiratory deficits, seizures premature death. However, only specific neuronal populations are affected. Furthermore, their molecular identity contribution the remains unknown. Here, using mouse model of LS lacking complex I subunit Ndufs4, we dissect role...
The striatum controls behaviors via the activity of direct and indirect pathway projection neurons (dSPN iSPN) that are intermingled in all compartments. While such cellular mosaic ensures balanced two pathways, its developmental origin pattern remains largely unknown. Here, we show both SPN populations specified embryonically intermix progressively through multidirectional iSPN migration. Using conditional mutant mice, found inactivation dSPN-specific transcription factor Ebf1 impairs...
Abstract Plasticity studies have consistently shown that behavioural relevance can change the neural representation of sounds in auditory system, but what occurs context natural acoustic communication where significance could be acquired through social interaction remains to explored. The zebra finch, a highly songbird species forms lifelong pair bonds and uses vocalization, distance call, identify its mate, offers an opportunity address this issue. Here, we recorded spiking activity females...
Dystonia is a movement disorder characterized by sustained or intermittent muscle contractions and its pathophysiological mechanisms are still poorly understood. Dominant mutations of the GNAL gene cause isolated dystonia (DYT25) in patients. Some result complete loss function encoded protein, Gαolf, an adenylyl-cyclase-stimulatory G-protein highly enriched striatal projection neurons, where it mediates actions dopamine adenosine. We used male female heterozygous Gnal knock-out mice...
Dystonia is often associated with functional alterations in the cerebello-thalamic pathways, which have been proposed to contribute disorder by propagating pathological firing patterns forebrain. Here, we examined function of pathways a model DYT25 dystonia. ( Gnal +/− ) mice carry heterozygous knockout mutation gene, notably disrupts striatal function, and systemic or administration oxotremorine these triggers dystonic symptoms. Our results reveal an increased excitability presymptomatic...
Travel can induce motion sickness (MS) in susceptible individuals. MS is an evolutionary conserved mechanism caused by mismatches between motion-related sensory information and past visual memory, triggering a malaise accompanied hypolocomotion, hypothermia, hypophagia, nausea. Vestibular nuclei (VN) are critical for the processing of movement input from inner ear. Motion-induced activation VN neurons recapitulates MS-related signs. However, genetic identity mediating autonomic aversive...
In Parkinson's disease, the degeneration of midbrain dopaminergic neurons is consistently associated with modified metabolic activity in cerebellum. Here we examined functional reorganization taking place cerebello-cerebral circuit a murine model disease 6-OHDA lesion neurons. Cerebellar optogenetic stimulations evoked similar movements control and lesioned mice, suggesting normal coupling cerebellum to motor effectors after lesion. freely moving animals, firing rate primary cortex was...
Abstract Chronic Levodopa therapy, the gold-standard treatment for Parkinson’s Disease (PD), leads to emergence of involuntary movements, called levodopa-induced dyskinesia (LID). Cerebellar stimulation has been shown decrease LID severity in PD patients. Here, order determine how cerebellar induces alleviation, we performed daily short trains optogenetic stimulations Purkinje cells (PC) freely moving mice. We demonstrated that these are sufficient suppress or even prevent their development....
Abstract The ability to recognize familiar individuals is crucial for establishing social relationships. zebra finch, a highly songbird species that forms lifelong pair bonds, uses vocalization, the distance call, identify its mate. However, in males, this depends on conditions, requiring presence of an audience. To evaluate whether bystanders modulates auditory processing underlying recognition abilities, we assessed, by using lightweight telemetry system, electrophysiological responses...
The role of the claustrum in consciousness and vigilance states was proposed more than two decades ago; however, its anesthesia is not yet understood, this requires investigation. aim our study to assess impact electrical stimulation during isoflurane adult rats. left hemisphere electrically stimulated using a bipolar tungsten electrode inserted stereotaxically. In order monitor anesthetic depth, electrocorticogram (ECoG) recorded before, during, after frontal parietal epidural electrodes...
Understanding how communication sounds are encoded in the central auditory system is critical to deciphering neural bases of acoustic communication. Songbirds use learned or unlearned vocalizations a variety social interactions. They have telencephalic areas specialized for processing natural and considered as playing role discrimination behaviorally relevant vocal sounds. The zebra finch, highly songbird species, forms lifelong pair bonds. Only male finches sing. However, both sexes produce...
ABSTRACT Travel can induce motion sickness (MS) in susceptible individuals. MS is an evolutionary conserved mechanism caused by mismatches between motion-related sensory information and past visual memory, triggering a malaise accompanied hypolocomotion, hypothermia, hypophagia nausea. Vestibular nuclei (VN) are critical for the processing of movement input from inner ear. Motion-induced activation VN neurons recapitulates MS-related signs. However, genetic identity mediating MS- related...
Passive motion can induce kinetosis (motion sickness, MS) in susceptible individuals. MS is an evolutionary conserved mechanism caused by mismatches between motion-related sensory information and past visual memory, triggering a malaise accompanied hypolocomotion, hypothermia, hypophagia aversion to novel foods presented coincidentally. Vestibular nuclei (VN) are critical for the processing of movement input, motion-induced activation VN neurons recapitulates MS-related signs. However,...
<title>Abstract</title> Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of untreatable disorders known as primary diseases (MD). Leigh syndrome (LS) is the most common pediatric MD and characterized by progressive neuromuscular affectation premature death. Here, we show that daily cannabidiol (CBD) administration significantly extends lifespan ameliorates pathology two LS mouse models, cellular function fibroblast from patients. CBD delays motor decline...
Abstract The striatum controls behaviors via the activity of direct and indirect pathway projection neurons (dSPN iSPN) that are intermingled in all compartments. While such mosaic ensures balanced two pathways, how it emerges remains largely unknown. Here, we show both SPN populations specified embryonically progressively intermix through multidirectional iSPN migration. Using conditional mutants dSPN-specific transcription factor Ebf1, found inactivating this gene impaired selective dSPN...
Abstract Dysfunctions of the mitochondrial energy-generating machinery cause a series progressive, untreatable and usually fatal diseases collectively known as disease. High energy-requiring organs such brain are especially affected, leading to developmental delay, ataxia, respiratory failure, hypotonia, seizures premature death. While neural affectation is critical component pathology, only discrete neuronal populations susceptible. However, their molecular identity contribution disease...
ABSTRACT Dystonia is often associated with functional alterations in the cerebello-thalamic pathways, which have been proposed to contribute disorder by propagating pathological firing patterns forebrain. Here, we examined function of pathways a model DYT25 dystonia, mice carrying heterozygous invalidation Gnal gene notably disrupts striatal function, exhibiting dystonic movements and postures following systemic or administration oxotremorine. Theta-burst optogenetic stimulations cerebellar...
SUMMARY Chronic Levodopa therapy, the gold-standard treatment of Parkinson’s Disease (PD), leads to emergence involuntary movements, called levodopa-induced dyskinesia (LID). Cerebellar stimulations have been shown decrease LID severity in PD patients. Here, order determine how cerebellar induce alleviation, we performed daily short trains optogenetic Purkinje cells (PC) freely moving mice. We demonstrated that these are sufficient suppress or even prevent their development. This symptomatic...