A5003482560- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Olfactory and Sensory Function Studies
- Nerve injury and regeneration
- Neurological disorders and treatments
- Zebrafish Biomedical Research Applications
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Pesticide and Herbicide Environmental Studies
- Environmental Toxicology and Ecotoxicology
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Cannabis and Cannabinoid Research
- Functional Brain Connectivity Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquatic Ecosystems and Biodiversity
- Silk-based biomaterials and applications
- Aquatic Ecosystems and Phytoplankton Dynamics
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Aquaculture Nutrition and Growth
Université Paris Sciences et Lettres
2020-2024
Centre National de la Recherche Scientifique
2020-2024
Institut Pasteur
2024
Inserm
2020-2023
Institut de Biologie de l'École Normale Supérieure
2020-2023
École Normale Supérieure - PSL
2022
Fundación Ciencias Exactas y Naturales
2016-2018
University of Buenos Aires
2011-2018
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2018
Abstract Fear conditioning is a form of associative learning that known to involve different brain areas, notably the amygdala, prefrontal cortex and periaqueductal grey (PAG). Here, we describe functional role pathways link cerebellum with fear network. We found cerebellar fastigial nucleus (FN) sends glutamatergic projections vlPAG synapse onto GABAergic neurons. Chemogenetic optogenetic manipulations revealed FN-vlPAG pathway controls bi-directionally strength memories, indicating an...
GluN3A is an atypical glycine-binding subunit of NMDA receptors (NMDARs) whose actions in the brain are mostly unknown. Here, we show that expression subunits controls excitability mouse adult cortical and amygdalar circuits via unusual signaling mechanism involving formation excitatory glycine GluN1/GluN3A (eGlyRs) their tonic activation by extracellular glycine. eGlyRs extrasynaptic reside specific neuronal populations, including principal cells basolateral amygdala (BLA) SST-positive...
Abstract Fear extinction is a form of inhibitory learning that suppresses the expression aversive memories and plays key role in recovery anxiety trauma-related disorders. Here, using male mice, we identify cerebello-thalamo-cortical pathway regulating fear extinction. The cerebellar fastigial nucleus (FN) projects to lateral subregion mediodorsal thalamic (MD), which reciprocally connected with dorsomedial prefrontal cortex (dmPFC). inhibition FN inputs MD mice impairs animals high...
Dystonia is often associated with functional alterations in the cerebello-thalamic pathways, which have been proposed to contribute disorder by propagating pathological firing patterns forebrain. Here, we examined function of pathways a model DYT25 dystonia. ( Gnal +/− ) mice carry heterozygous knockout mutation gene, notably disrupts striatal function, and systemic or administration oxotremorine these triggers dystonic symptoms. Our results reveal an increased excitability presymptomatic...
Abstract Chronic Levodopa therapy, the gold-standard treatment for Parkinson’s Disease (PD), leads to emergence of involuntary movements, called levodopa-induced dyskinesia (LID). Cerebellar stimulation has been shown decrease LID severity in PD patients. Here, order determine how cerebellar induces alleviation, we performed daily short trains optogenetic stimulations Purkinje cells (PC) freely moving mice. We demonstrated that these are sufficient suppress or even prevent their development....
ABSTRACT The olfactory epithelium (OE) has the remarkable capability to constantly replace receptor neurons (ORNs) due presence of neural stem cells (NSCs). For this reason, OE provides an excellent model study neurogenesis and neuronal differentiation. In present work, we induced degeneration in Xenopus laevis larvae by bilateral axotomy nerves. We found that induces specific‐ death through apoptosis between 24 48h post‐injury. concordance, there was a progressive decrease mature‐ORN marker...
ABSTRACT Motor skill learning is a complex and gradual process that involves the cortex basal ganglia, both crucial for acquisition long-term retention of skills. The cerebellum, which rapidly learns to adjust movement, connects motor striatum via ventral intralaminar thalamus respectively. Here, we evaluated contribution cerebellar neurons projecting these thalamic nuclei in skilled locomotion task mice. Using targeted chemogenetic inhibition preserves abilities, found contribute...
Motor skill learning is a complex and gradual process that involves the cortex basal ganglia, both crucial for acquisition long-term retention of skills. The cerebellum, which rapidly learns to adjust movement, connects motor striatum via ventral intralaminar thalamus respectively. Here, we evaluated contribution cerebellar neurons projecting these thalamic nuclei in skilled locomotion task mice. Using targeted chemogenetic inhibition preserves abilities, found contribute expression, while...
Motor skill learning is a complex and gradual process that involves the cortex basal ganglia, both crucial for acquisition long-term retention of skills. The cerebellum, which rapidly learns to adjust movement, connects motor striatum via ventral intralaminar thalamus respectively. Here, we evaluated contribution cerebellar neurons projecting these thalamic nuclei in skilled locomotion task mice. Using targeted chemogenetic inhibition preserves abilities, found contribute expression, while...
Abstract Fear conditioning is a form of associative learning that known to involve brain areas, notably the amygdala, prefrontal cortex and periaqueductal grey (PAG). Here, we describe functional role pathways link cerebellum with fear network. We found cerebellar fastigial nucleus (FN) sends glutamatergic projections vlPAG synapse onto GABAergic neurons. Chemogenetic optogenetic manipulations revealed FN-vlPAG pathway controls bi-directionally strength memory, indicating in association...
P. clarkii juvenile crayfish were exposed during 60 days to sublethal concentrations of glyphosate (G), polyoxyehtylene amine (P) or a combination both (G+P), together with control group aged tap water (C). At the end experiment, following statistical differences noted, respect control: 1) lower metabolic rate in G and G+P groups, 2) higher glycemia no hemolymphatic lactate levels, 3) muscle glycogen levels P 4) level protein group. Taken together, these results suggest that may cause...
SUMMARY The contribution of cerebellum to motor learning is often considered be limited adaptation, a short-timescale tuning reflexes and previous learned skills. Yet, the reciprocally connected two main players learning, cortex basal ganglia, via ventral midline thalamus respectively. Here, we evaluated cerebellar neurons projecting these thalamic nuclei in skilled locomotion task mice. In nuclei, found task-specific neuronal activities during task, lasting changes after suggesting an...
SUMMARY Chronic Levodopa therapy, the gold-standard treatment of Parkinson’s Disease (PD), leads to emergence involuntary movements, called levodopa-induced dyskinesia (LID). Cerebellar stimulations have been shown decrease LID severity in PD patients. Here, order determine how cerebellar induce alleviation, we performed daily short trains optogenetic Purkinje cells (PC) freely moving mice. We demonstrated that these are sufficient suppress or even prevent their development. This symptomatic...