A5089811664- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Neurobiology and Insect Physiology Research
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Lipid Membrane Structure and Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Renin-Angiotensin System Studies
- Regulation of Appetite and Obesity
- Retinal Development and Disorders
- Biochemical Analysis and Sensing Techniques
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Infant Health and Development
- Cannabis and Cannabinoid Research
- PI3K/AKT/mTOR signaling in cancer
- Nicotinic Acetylcholine Receptors Study
- Pancreatic function and diabetes
- Photoreceptor and optogenetics research
- Biotin and Related Studies
- Diet, Metabolism, and Disease
- Pharmacological Receptor Mechanisms and Effects
Instituto de Neurociencias
2018-2024
Consejo Superior de Investigaciones Científicas
2023
University of Maryland, Baltimore
2014-2016
Stanford University
2010-2015
Palo Alto University
2010
University of Michigan
2010
Universidad Complutense de Madrid
2003-2006
Each year, 10 million people worldwide survive the neurologic injury associated with a stroke. Importantly, stroke survivors have more than twice risk of subsequently developing dementia compared who never had The link between and later development is not understood. There are reports oligoclonal bands in CSF patients, suggesting that some B-lymphocyte response to may occur CNS. Therefore, we tested hypothesis could contribute onset dementia. We discovered that, mouse models, activated...
A neuropeptide kills patient's motivation Chronic pain is not only extremely disturbing and unpleasant; it can also make people depressed demotivated. What causes these effects? Schwartz et al. discovered that chronic changes in the way a called galanin affects certain neurons brain region nucleus accumbens (see Perspective by Fields). Galanin influences variety of behaviors, including feeding aspects pain. In this case, depresses synaptic transmission at specific excitatory synapses. It...
Abstract Oxytocin (OXT) and arginine vasopressin (AVP) support a broad range of behaviors homeostatic functions including sex-specific context-appropriate social behaviors. Although the alterations these systems have been linked with social-related disorders such as autism spectrum disorder, their formation developmental dynamics remain largely unknown. Using novel brain clearing techniques 3D imaging, we reconstructed specification oxytocinergic vasopressinergic circuits in developing mouse...
Postsynaptic AMPA-type glutamate receptors (AMPARs) are among the major determinants of synaptic strength and can be trafficked into out synapses. Neuronal activity regulates AMPAR trafficking during plasticity to induce long-term changes in strength, including potentiation (LTP) depression (LTD). Rab family GTPases regulate most membrane eukaryotic cells; particularly, Rab11 its effectors implicated mediating postsynaptic insertion LTP. To explore function Rab11Fip5, a neuronal effector...
Hippocampal interneurons comprise a diverse family of inhibitory neurons which function is critical for fine information processing. Along with gamma-aminobutyric acid (GABA), secrete myriad neuroactive substances via secretory vesicles molecular composition and regulatory mechanisms remain unknown. In this study, we have carried out an immunohistofluorescence analysis to describe the content in distinct populations hippocampal neurons. Our results indicate that phogrin, integral protein...
In primary cultures of rat cerebellar granule cells with a functional network glutamatergic neurons, the expression pattern different subunits nitric-oxide (NO)-sensitive guanylyl cyclase changes during cell differentiation. These express alpha1, alpha2 and beta1 NO-sensitive synthesize cyclic guanosine monophosphate (cGMP) in response to exogenous or endogenous nitric oxide. this study, we determined protein content alpha1 quantified mRNA by reverse transcription coupled polymerase chain...
Activation of N-methyl-D-aspartate (NMDA) glutamate receptors commonly affects gene expression in different neurons. We reported previously that chronic treatment rat cerebellar granule cells with NMDA (24 hours) upregulates the mRNA encoding α2 subunit nitric-oxide-sensitive guanylyl cyclase. However, molecular mechanisms involved this process remained to be elucidated. Here, we have performed mRNA-decay experiments using transcriptional inhibitor actinomycin D, providing evidence half-life...
ABSTRACT It is well-established that Rab11-dependent recycling endosomes drive the activity-dependent delivery of AMPA receptors (AMPARs) into synapses during long-term potentiation (LTP). Nevertheless, molecular basis for this specialized function still unknown. Here, we have investigated RAB11FIP2 (FIP2 hereafter) as a potential effector trafficking LTP in rat hippocampal slices. Surprisingly, found FIP2 operates independently from Rab11 proteins, and acts negative regulator AMPAR...
Abstract Normal aging and many age-related disorders such as Alzheimer’s disease cause deficits in olfaction; however, it is currently unknown how natural pathological impacts the detection of social odors which might contribute to impoverishment behavior at old age further worsening overall health. Analysis vomeronasal organ, main gateway pheromone-encoded information, indicated that distinctively affects neurogenic ability sensory epithelium. Whereas cell proliferation remained majorly...
Abstract Oxytocin (OXT) and arginine vasopressin (AVP) support sex-specific context-appropriate social behaviors. Although alterations of these systems underlie the appearance neuropsychiatric disorders, their formation developmental dynamics remain largely unknown. Using novel brain clearing techniques 3D imaging, we have reconstructed specification oxytocinergic vasopressinergic circuits in developing mouse with unprecedented cellular resolution. A systematic quantification indicates that...
Understanding the intricate mechanisms underlying memory formation and retention relies on unraveling how hippocampus, a structure fundamental for acquisition, is organized. Within complex hippocampal network, interneurons play crucial role in orchestrating processes. Among these interneurons, Oriens-Lacunosum Moleculare (OLM) cells emerge as key regulators, governing flow of information to CA1 pyramidal cells. In this review, we explore OLM detail, describing their effects processing,...