A5086414663- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Cellular transport and secretion
- Educational Practices and Policies
- Brain Metastases and Treatment
- Lipid Membrane Structure and Behavior
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Higher Education and Sustainability
- Neuroendocrine regulation and behavior
- Cardiac electrophysiology and arrhythmias
- Biochemical Analysis and Sensing Techniques
- E-Learning and Knowledge Management
- Cardiac pacing and defibrillation studies
- Olfactory and Sensory Function Studies
- Photoreceptor and optogenetics research
- Aging, Health, and Disability
- stochastic dynamics and bifurcation
- Health and Medical Education
- Neurobiology and Insect Physiology Research
- Atrial Fibrillation Management and Outcomes
- Advanced Memory and Neural Computing
Universidad Complutense de Madrid
2012-2024
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2020-2024
Instituto Cajal
2015-2023
Consejo Superior de Investigaciones Científicas
2015-2021
Universidad de Málaga
2018
King's College London
2017
Contactin-associated protein-like 2 (Caspr2) is found at the nodes of Ranvier and has been associated with physiological properties white matter conductivity. Genetic variation in CNTNAP2, gene encoding Caspr2, linked to several neurodevelopmental conditions, yet pathophysiological effects CNTNAP2 mutations on axonal physiology brain myelination are unknown. Here, we have investigated mouse mutants for Cntnap2 profound deficiencies clustering Kv1-family potassium channels juxtaparanodes...
Abstract The reactivation of experience-based neural activity patterns in the hippocampus is crucial for learning and memory. These their associated sharp-wave ripples (SWRs) are highly variable. However, this variability missed by commonly used spectral methods. Here, we use topological dimensionality reduction techniques to analyze waveform recorded at pyramidal layer CA1. We show that SWR waveforms distribute along a continuum low-dimensional space, which conveys information about...
Understanding brain operation demands linking basic behavioral traits to cell-type specific dynamics of different brain-wide subcircuits. This requires a system classify the operational modes neurons and circuits. Single-cell phenotyping firing behavior during ongoing oscillations in vivo has provided large body evidence on entorhinal–hippocampal function, but data are dispersed diverse. Here, we mined literature search for information regarding phase-timing over 100 hippocampal/entorhinal...
A high percentage of patients with brain metastases frequently develop neurocognitive symptoms; however, understanding how metastasis co-opts the function neuronal circuits beyond a tumor mass effect remains unknown. We report comprehensive multidimensional modeling functional analyses in context metastasis. By testing different preclinical models from various primary sources and oncogenic profiles, we dissociated heterogeneous impact on local field potential oscillatory activity cortical...
The proximodistal axis is considered a major organizational principle of the hippocampus. At interface between hippocampus and other brain structures, CA2 apparently breaks this rule. region involved in social, temporal, contextual memory function, but mechanisms remain elusive. Here, we reveal cell-type heterogeneity characteristic expression gradient transcription factor Sox5 within rat. Using intracellular extracellular recordings followed by neurochemical identification single cells,...
Abstract Cognitive function relies on a balanced interplay between excitatory and inhibitory neurons (INs), but the impact of estradiol IN is not fully understood. Here, we characterize regulation hippocampal INs by aromatase, enzyme responsible for synthesis, using combination molecular, genetic, functional behavioral tools. The results show that CA1 parvalbumin-expressing (PV-INs) contribute to brain synthesis. Brain aromatase regulates synaptic inhibition through mechanism involves...
The relationship between the extracellularly measured electric field potential resulting from synaptic activity in an ensemble of neurons and intracellular signals these is important but still open question. Based on a model neuron with cylindrical dendrite lumped soma, we derive formula that substantiates proportionality local total somatic transmembrane current emerges difference dendritic membrane potentials. tested by intra- extracellular recordings evoked responses hippocampal slices....
Changes in neuronal activity often trigger compensatory mechanisms aimed at regulating network homeostatically. Here we have identified and characterized a novel form of short-term plasticity membrane excitability, which develops early after the eye-opening period rats (P16-19 days) but not before that developmental stage (P9-12 days old). Holding potential CA1 neurons right below firing threshold from 15 s to several minutes induced potentiation repolarizing phase action potentials...
The proximodistal axis is considered a major organizational principle of the hippocampus. Interfacing between hippocampus and other brain systems, CA2 region apparently breaks this rule. Apart from its specific role in social memory, has been involved temporal contextual memory but mechanisms remain elusive. Here, we used intracellular extracellular recordings followed by neurochemical identification single-cells to evaluate surrounding areas rat. We found marked trends synaptic activity, as...
The proximodistal axis is considered a major organizational principle of the hippocampus. Interfacing between hippocampus and other brain systems, CA2 region apparently breaks this rule. Apart from its specific role in social memory, has been involved temporal contextual memory but mechanisms remain elusive. Here, we used intracellular extracellular recordings followed by neurochemical identification single-cells to evaluate surrounding areas rat. We found marked trends synaptic activity, as...
M. Hernández-Martín1M.D. Vicente-Torres2L. Rivera1D. Prieto1S. Benedito1N. De las Heras2A. López-Calderón2J.A. García-Donaire3M. Abad-Cardiel3N. Martell3R. Redondo-Castillejo1S.D. Paredes2D. Gómez-Garre2J.A. Issa1M.P. Montenegro1C. Contreras1V. Azcutia1M.C. Lozano-Estevan 4V. Hurtado-Carneiro2R. Rodrígues-Díez2A.I. Martín-Velasco2F. Das Chagas Vasconcelos2G. Segovia2T. Priego2R. Gredilla2V. Cachofeiro2M.V. Hernández1A. Agis-Torres1P. Recio1M. Muñoz-Picos1J. Navarro-Dorado1N.F. Pascual1B....
Abstract A high percentage of patients with brain metastases frequently develop neurocognitive symptoms, however understanding how metastasis co-opt the function neuronal circuits beyond a mass effect remains unknown. We report comprehensive multidimensional modelling functional analysis in context metastasis. By testing different pre-clinical models from various primary sources and oncogenic profiles we dissociated heterogeneous impact on that detected homogeneous inter-model tumor size or...
M. Hernández Martín1A. Sánchez-Pina1R. Redondo-Castillejo1J.A. Issa1M.A. Vicente-Torres2S.D. Paredes2N. de las Heras2A. López-Calderón2G. Segovia2V. Azcutia1V. Hurtado2A.I. Martín-Velasco2C. Contreras1T. Priego2D. Gómez-Garre2M.P. Montenegro1P. Recio1I. Rodriguez-Ramiro1V. Cachofeiro2A. Gómez del Val1M. Muñoz-Picos1J. Navarro-Dorado 1N.F. Pascual1B. Colino1V.S. Leite1A. Agis-Torres1R. Raposo1J.M. Bravo2A. Sanchez-Aguilera2M. Sancho2E. Martinez-Martinez2E. Nebot2R. Rodrígues-Díez2R....