A5005865304- Fatty Acid Research and Health
- Immune Cell Function and Interaction
- Gastroesophageal reflux and treatments
- CAR-T cell therapy research
- Biochemical Analysis and Sensing Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Biosimilars and Bioanalytical Methods
- Animal Nutrition and Physiology
- Immunodeficiency and Autoimmune Disorders
- Peroxisome Proliferator-Activated Receptors
- T-cell and B-cell Immunology
- Viral Infectious Diseases and Gene Expression in Insects
- Biomedical and Engineering Education
- Blood disorders and treatments
- Pharmacovigilance and Adverse Drug Reactions
- Biotin and Related Studies
- Acute Lymphoblastic Leukemia research
- Drug-Induced Adverse Reactions
- SARS-CoV-2 and COVID-19 Research
- Respiratory and Cough-Related Research
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
University Medical Center Utrecht
2014-2024
Utrecht University
2015-2024
Groene Hart Ziekenhuis
2022-2024
Medisch Centrum Leeuwarden
2019
In many cancers, the expression of immunomodulatory ligands leads to immunoevasion, as exemplified by interaction PD-L1 with PD-1 on tumor-infiltrating lymphocytes. Profound advances in cancer treatments have come advent immunotherapies directed at blocking these immuno-suppressive ligand-receptor interactions. However, although there has been success use immune checkpoint interventions, correct patient stratification for therapies challenging.To address this issue stratification, we...
Contactin-associated protein-like 2 (Caspr2) is found at the nodes of Ranvier and has been associated with physiological properties white matter conductivity. Genetic variation in CNTNAP2, gene encoding Caspr2, linked to several neurodevelopmental conditions, yet pathophysiological effects CNTNAP2 mutations on axonal physiology brain myelination are unknown. Here, we have investigated mouse mutants for Cntnap2 profound deficiencies clustering Kv1-family potassium channels juxtaparanodes...
Lifelong immunosuppression is required for allograft survival after kidney transplantation but may not ultimately prevent loss resulting from chronic rejection. We developed an approach that attempts to abrogate immune rejection and the need post-transplantation in three patients with Schimke immuno-osseous dysplasia who had both T-cell immunodeficiency renal failure. Each patient received sequential transplants of αβ T-cell-depleted CD19 B-cell-depleted haploidentical hematopoietic stem...