A5016224747- Urinary Bladder and Prostate Research
- Nitric Oxide and Endothelin Effects
- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eicosanoids and Hypertension Pharmacology
- Neuroendocrine regulation and behavior
- Cardiac electrophysiology and arrhythmias
- Kidney Stones and Urolithiasis Treatments
- Ion channel regulation and function
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Pharmacology and Obesity Treatment
- Insurance, Mortality, Demography, Risk Management
- Global Health Care Issues
- Mast cells and histamine
- Migraine and Headache Studies
- Heart Rate Variability and Autonomic Control
- Sulfur Compounds in Biology
- Hypothalamic control of reproductive hormones
Universidad Complutense de Madrid
2016-2025
Universidad Rey Juan Carlos
2022-2024
Sociedad Española de Cardiología
2013-2014
Universidad de Cantabria
1999-2008
Universidade de Santiago de Compostela
2008
Hospital Universitario Ramón y Cajal
2004-2006
Aarhus University
1990-1997
University Medical Center
1997
Boston University
1997
Aarhus University Hospital
1990
Oxidative stress-associated endothelial dysfunction is a key pathogenic factor underlying the microvascular complications of metabolic disease. NADPH oxidase (Nox) major source oxidative stress in diabetic nephropathy and chronic kidney disease, despite Nox4 Nox2 have been identified as relevant sources vasodilator H2O2.The present study was sought to investigate role Nox enzymes renal vascular rat model genetic obesity. Endothelial function assessed intrarenal arteries obese Zucker rats...
The role of NADPH oxidase (Nox)-derived reactive oxygen species in kidney vascular function has extensively been investigated the harmful context oxidative stress diabetes and obesity-associated disease. Since hydrogen peroxide (H2O2) recently involved non-nitric oxide (NO) non-prostanoid relaxations intrarenal arteries, present study was sought to investigate whether oxidases may be functional sources vasodilator H2O2 assess their endothelium-dependent human rat arteries. Renal interlobar...
Background and Purpose We assessed whether endothelin‐1 ( ET ‐1) inhibits NO contributes to endothelial dysfunction in penile arteries a model of insulin resistance‐associated erectile ED ). Experimental Approach Vascular function was arteries, from obese OZR ) lean LZR Z ucker rats, mounted microvascular myographs. Changes basal stimulated levels superoxide O 2 − were detected by lucigenin‐enhanced chemiluminescence receptor expression determined immunohistochemistry. Key Results ‐1 acute...
AMP-activated protein kinase (AMPK) is a cellular energy sensor activated during stress to stimulate ATP production pathways and restore homeostasis. AMPK widely expressed in the kidney involved mitochondrial protection biogenesis upon acute renal ischemia, activity being blunted metabolic disease-associated disease. Since little known about regulation of blood flow, present study aimed assess role vascular function. Functional responses selective activator A769662 were assessed intrarenal...
Background/Objective: The prevalence of kidney stones has increased, especially in industrialized countries. Obesity and metabolic syndrome have also risen significantly are considered factors driving this trend. Our goal was to assess the hospitalization burden identify epidemiological trends Spain over past 25 years. Additionally, study analyzed relationship between data stone patients obesity-coded diagnoses hospital discharges. Methods: A retrospective observational conducted with from...
We have studied the effects of α‐ and β‐adrenoceptor agonists antagonists on both phasic peristaltic activity basal tone isolated intravesical ureter pig by means isometric techniques in vitro . Spontaneous was exhibited 21% preparations manifested as rhythmic contractions with average frequency amplitude 2.54 ± 0.18 min −1 1.48 0.16 g ( n = 31), respectively. Adrenaline, noradrenaline phenylephrine induced concentration‐dependent increases ureteral preparations, all three being more potent...
Erectile dysfunction frequently coexists with coronary artery disease and has been proposed as a potential marker for silent in type 2 diabetes. In the present study, we comparatively assessed structural functional changes of both penile arteries (PAs) (CAs) from prediabetic animal model. PAs CAs 17- to 18-wk-old obese Zucker rats (OZRs) their control counterparts [lean (LZRs)] were mounted microvascular myographs evaluate vascular function, stained subjected morphometric analysis....
Objective Erectile dysfunction (ED) is considered as an early sign of vascular disease due to its high prevalence in patients with cardiovascular risk factors. Endothelial and neural involving nitric oxide (NO) are usually implicated the pathophysiology diabetic ED, but underlying mechanisms unclear. The present study assessed role oxidative stress dysfunctional vasodilator responses penile arteries obese Zucker rat (OZR), experimental model metabolic syndrome/prediabetes. Methods Results...
To study the influence of alpha-adrenergic stimuli on non-adrenergic non-cholinergic (NANC) neurogenic relaxation in isolated horse penile resistance arteries.Deep intracavernous arteries with an internal lumen diameter 200-500 microns., from corpus cavernosum young horses, were mounted microvascular myographs for isometric tension recording and electrical field stimulation (EFS) autonomic nerve terminals.In presence guanethidine (10(-5) M) atropine (10(-7) tone was raised by thromboxane...
1. A pharmacological characterization of tyrosine kinase inhibitors (TKI) belonging to two distinct groups (competitors at the ATP-binding site and substrate-binding site, respectively) was performed, based on their effects contractility rat mesenteric arteries. 2. Both ATP-site competitors (genistein its inactive analogue, daidzein) substrate-site (tyrphostins A-23, A-47 A-1) reversibly inhibited noradrenaline (NA, (10 microM)) KCl (125 mM) induced contractions, concentration-dependently....
To assess whether iron and folic acid supplementation reduce the risk of low birthweight (LBW) in women without anaemia.Case-control study.University Hospital Cantabria.Cases were 322 mothers anaemia delivering a singleton infant less than 2500 g. Controls 934 term non-small-for-gestational-age infant.Data on obtained from prenatal chart record personal interview. Data factors for LBW also gathered.Agreement between two sources information was good (82% 94% iron). Odds ratios yielded very...
<h3>Background:</h3> Type 2 familial partial lipodystrophy (FPLD2) is characterised by loss of fat in the limbs and buttocks results from mutations <i>LMNA</i> gene. <h3>Aim:</h3> To evaluate role several genes involved adipogenesis order to better understand underlying mechanisms regional subcutaneous adipose tissue (scAT) patients with FPLD2. <h3>Methods:</h3> In total, 7 FPLD2 10 healthy control participants were studied. A minimal model was used calculate insulin sensitivity (IS). scAT...
No AccessJournal of UrologyInvestigative Urology1 Aug 2013Hydrogen Sulfide Mediated Inhibitory Neurotransmission to the Pig Bladder Neck: Role KATP Channels, Sensory Nerves and Calcium Signaling Vítor S. Fernandes, Ana S.F. Ribeiro, María Victoria Barahona, Luis M. Orensanz, Martínez-Sáenz, Paz Recio, Cristina Martínez, Salvador Bustamante, Joaquín Carballido, Albino García-Sacristán, Dolores Prieto, Medardo Hernández FernandesVítor Fernandes Departamento de Fisiología, Facultad Farmacia,...
The involvement of nitric oxide (NO) and the signal transduction mechanisms mediating neurogenic relaxations were investigated in deep intracavernous penile arteries with an internal lumen diameter 600-900 pm, isolated from corpus cavernosum young horses. 2The presence synthase (NOS)-positive nerves was examined cross longitudinal sections processed for NADPH-diaphorase (NADPH-d) histochemistry.NADPH-d-positive nerve fibres observed adventitia-media junction relation to trabecular smooth...
Penile small arteries (effective internal lumen diameter of 300–600 μm) were isolated from the horse corpus cavernosum and mounted in microvascular myographs order to investigate mechanisms underlying endothelium‐dependent relaxations acetylcholine (ACh) bradykinin (BK). In preconstricted with thromboxane analogue U46619 (3–30 n M ), ACh BK elicited concentration‐dependent relaxations, pD 2 maximal responses being 7.71±0.09 91±1% ( =23), 8.80±0.07 89±2% =24) for BK, respectively. These...