A5030302921- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Ureteral procedures and complications
- Renal and Vascular Pathologies
- Dialysis and Renal Disease Management
- Healthcare Systems and Technology
- Hormonal and reproductive studies
- Abdominal Surgery and Complications
- Urinary Bladder and Prostate Research
- Organ Donation and Transplantation
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Eicosanoids and Hypertension Pharmacology
- Organ Transplantation Techniques and Outcomes
- Pelvic floor disorders treatments
- Hormonal Regulation and Hypertension
- Chronic Kidney Disease and Diabetes
- Sexual Differentiation and Disorders
- Nitric Oxide and Endothelin Effects
- Urologic and reproductive health conditions
- Melanoma and MAPK Pathways
- Cutaneous Melanoma Detection and Management
- Metabolism, Diabetes, and Cancer
- Hernia repair and management
- Pharmacology and Obesity Treatment
Hospital Universitario Puerta de Hierro Majadahonda
2016-2025
Universidad Rey Juan Carlos
2010-2025
Complejo Hospitalario Universitario de Toledo
2015-2025
Hospital Universitario de Toledo
2025
Hospital Virgen de la Salud
2021-2022
Hospital Universitario Sanitas La Moraleja
2016
Hospital General de La Rioja
2016
Hospital Universitario de Fuenlabrada
2006-2010
Clínica MEDS (Chile)
2008
Hospital Virgen del Camino
2002-2006
Oxidative stress-associated endothelial dysfunction is a key pathogenic factor underlying the microvascular complications of metabolic disease. NADPH oxidase (Nox) major source oxidative stress in diabetic nephropathy and chronic kidney disease, despite Nox4 Nox2 have been identified as relevant sources vasodilator H2O2.The present study was sought to investigate role Nox enzymes renal vascular rat model genetic obesity. Endothelial function assessed intrarenal arteries obese Zucker rats...
AMP-activated protein kinase (AMPK) is a cellular energy sensor activated during stress to stimulate ATP production pathways and restore homeostasis. AMPK widely expressed in the kidney involved mitochondrial protection biogenesis upon acute renal ischemia, activity being blunted metabolic disease-associated disease. Since little known about regulation of blood flow, present study aimed assess role vascular function. Functional responses selective activator A769662 were assessed intrarenal...
The role of NADPH oxidase (Nox)-derived reactive oxygen species in kidney vascular function has extensively been investigated the harmful context oxidative stress diabetes and obesity-associated disease. Since hydrogen peroxide (H2O2) recently involved non-nitric oxide (NO) non-prostanoid relaxations intrarenal arteries, present study was sought to investigate whether oxidases may be functional sources vasodilator H2O2 assess their endothelium-dependent human rat arteries. Renal interlobar...
Background/Objective: The prevalence of kidney stones has increased, especially in industrialized countries. Obesity and metabolic syndrome have also risen significantly are considered factors driving this trend. Our goal was to assess the hospitalization burden identify epidemiological trends Spain over past 25 years. Additionally, study analyzed relationship between data stone patients obesity-coded diagnoses hospital discharges. Methods: A retrospective observational conducted with from...
Pyrexia is the most common adverse event in patients treated with dabrafenib plus trametinib. However, pathogenesis of pyrexia and factors to identify at higher risk developing remain unknown. The ELDERLYMEL study was a multicenter, noninterventional, retrospective, real-world comparing effectiveness safety trametinib between elderly (≥75 years, n = 29) younger (<75 130) advanced melanoma BRAF V600-mutated Spain. Surprisingly, significantly less frequent (13.8%) than (42.3%). post hoc...
Based on the mechanism of action, combining somatostatin analogues (SSAs) with mTOR inhibitors or antiangiogenic agents may provide synergistic effects for treatment patients neuroendocrine tumours (NETs). Herein, we investigate use these combinations in clinical practice. This retrospective cross-sectional analysis NETs treated SSA lanreotide and targeted therapies at 35 Spanish hospitals evaluated efficacy safety The data 159 133 was retrospectively collected. Of patients, a median age...
Mitochondrial ATP-sensitive K+ (mitoKATP) channels are involved in neuronal and cardiac protection from ischemia oxidative stress. Penile erection is a neurovascular event mediated by relaxation of the erectile tissue via nitric oxide (NO) released nerves endothelium. In present study, we investigated whether mitoKATP play role control penile vascular tone mitochondrial dynamics, involvement NO. The effect selective activator BMS191095 was examined on tone, bioenergetics real-time...
Urolithiasis is a worldwide problem and risk factor for kidney injury. Oxidative stress-associated renal endothelial dysfunction secondary to urolithiasis could be key pathogenic factor, similar obesity diabetes-related nephropathy. The aim of the present study was characterize urolithiasis-related in hyperoxaluria rat model lithiasis.Endothelial assessed preglomerular arteries isolated from control rats which 0.75% ethylene glycol administered drinking water. Renal interlobar were mounted...
Background and Purpose Obesity is a risk factor for the development of chronic kidney disease independent diabetes, hypertension other co‐morbidities. Obesity‐associated nephropathy linked to dysregulation cell energy sensor AMP‐activated protein kinase ( AMPK ). We aimed here assess whether impairment activity may cause renal arterial dysfunction in obesity evaluate therapeutic potential activating AMPK. Experimental Approach Effects activator A769662 were assessed on intrarenal arteries...
Arachidonic acid (AA)-derived cytochrome P450 (CYP) derivatives, epoxyeicosatrienoic acids (EETs) and 20-hidroxyeicosatetranoic (20-HETE), play a key role in kidney tubular vascular functions blood pressure. Altered metabolism of CYP epoxygenases hydroxylases has differentially been involved the pathogenesis metabolic disease-associated complications, although mechanisms responsible for injury are unclear. The present study aimed to assess whether obesity-induced changes enzymes may...
OBJECTIVES: The surgical procedures for the insertion of tension free vaginal tapes in treatment female stress urinary incontinence (SUI) are simple and can be done as outpatient operations. aim this study was to perform a budget comparing TVT an basis with transobturator tape (TOT) hospital admission.METHODS: Retrospective analysis medical recordsof 23 patients undergoing surgery SUI betweenOctober 2004 October 2005. 13 were treated by (group 1, Departmentof Urology), 10 TOT...