A5014651094- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Sleep and related disorders
- Dietary Effects on Health
- Effects and risks of endocrine disrupting chemicals
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Hops Chemistry and Applications
- E-Learning and Knowledge Management
- Coffee research and impacts
- Cardiac Ischemia and Reperfusion
- Advanced Glycation End Products research
- Coenzyme Q10 studies and effects
- Education and Critical Thinking Development
- Organ Transplantation Techniques and Outcomes
- Carcinogens and Genotoxicity Assessment
- Cannabis and Cannabinoid Research
- Genetics, Aging, and Longevity in Model Organisms
Universidad Complutense de Madrid
2014-2025
University Hospital Complex Of Vigo
2024
Consorci Sanitari de Terrassa
2023
Hospital Clínico San Carlos
2022
Universidad de Extremadura
2004-2012
The University of Texas Health Science Center at San Antonio
2008-2010
The University of Texas at San Antonio
2009-2010
The University of Texas System
2008
The University of Texas Health Science Center at Houston
2008
Repsol (Spain)
2004
Melatonin is a molecule present in multitude of taxa and may be ubiquitous organisms. It has been found bacteria, unicellular eukaryotes, macroalgae, fungi, plants animals. A primary biological function melatonin primitive organisms antioxidant defence to protect against toxic free radical damage. During evolution, adopted by multicellular perform many other functions. These functions likely include the chemical expression darkness vertebrates, environmental tolerance fungi plants, sexual...
Abstract: The role of melatonin in the mediation apoptotic events has recently gained attention, especially after recent studies have reported that exerts antiapoptotic actions normal cells but may activate proapoptotic pathways some tumor cells. Here, we evaluated effect on apoptosis human leukemia cell line HL‐60. Melatonin treatment (1 m ) induced a significant increase caspase‐3 and ‐9 activities. activation caspases was time dependent, reaching maximum 12 hr stimulation, then decreasing...
Tryptophan, serotonin, and melatonin, present in Jerte Valley cherries, participate sleep regulation exhibit antioxidant properties. The effect of the intake seven different cherry cultivars on sleep–wake cycle, 6-sulfatoxymelatonin levels, urinary total capacity middle-aged elderly participants was evaluated. Volunteers were subjected to actigraphic monitoring record display temporal patterns their nocturnal activity rest. quantified by enzyme-linked immunosorbent assay colorimetric kits,...
Bisphenol A (BPA) is a phenolic compound used in plastics elaboration for food protection or packaging. BPA-monomers can be released into the chain, resulting continuous and ubiquitous low-dose human exposure. This exposure during prenatal development especially critical could lead to alterations ontogeny of tissues increasing risk developing diseases adulthood. The aim was evaluate whether BPA administration (0.036 mg/kg b.w./day 3.42 b.w./day) pregnant rats induce liver injury by...
The intracellular environmental is a hostile one. Free radicals and related oxygen nitrogen-based oxidizing agents persistently pulverize damage molecules in the vicinity of where they are formed. mitochondria especially subjected to frequent abundant oxidative abuse. carnage that left wake these nitrogen-related reactants referred as or stress. When mitochondrial electron transport complex inhibitors used, e.g., rotenone, 1-methyl-1-phenyl-1,2,3,6-tetrahydropyridine, 3-nitropropionic acid...
Abstract: Apoptosis or programmed cell death plays a critical role in both inflammatory and immune responses. Recent evidence demonstrates that control of leukocyte apoptosis is one the most striking system-related roles melatonin. For this reason, study evaluated protective effects melatonin on human induced by sustained cytosolic calcium increases. Such are likely mediated melatonin's free-radical scavenging actions. Treatments with specific inhibitor re-uptake, thapsigargin (TG), and/or...
Serotonin, one of the most important neurotransmitters in central nervous system, is synthesized by amino acid, tryptophan. Given that this essential acid consumed diet, aim study was to evaluate effect orally administered L-tryptophan (125 mg/kg) on circadian variations levels serotonin brain and plasma. We used male Wistar rats 14 +/- 2 weeks age (n = 240), maintained under conditions a 12-hr light:dark cycle, food water ad libitum. Tryptophan administration gavage daily single dose at 7...
In the present review we summarize relationship between amino acid, tryptophan, neurotransmitter, serotonin, and indole, melatonin, with rhythms of sleep/wake immune response along possible connections alterations in these due to aging so-called "serotonin melatonin deficiency state." The decrease associated brain circulating levels serotonin seemingly contributes both cycle that typically accompany old age. supplemental administration e.g. inclusion tryptophan-enriched food diet, might help...
Red grapes contain elevated amounts of antioxidant compounds (polyphenols) that may potentially prevent cell aging, cardiovascular disease and oxidation-related disorders. Since functional drinks are presently one the most dynamic sectors market, present work was aimed at evaluating possible effect an experimental grape juice in terms urinary 6-sulfatoxymelatonin (aMT6-s) total capacity young (20 ± 10 yr-old), middle-aged (45 yr-old) elderly (75 individuals. Grapes (Vitis vinifera cv....
In the present work, we evaluated effect of intake a Jerte Valley cherry-based product (JVCP), compared to placebo product, on sleep quality, urinary 6-sulfatoxymelatonin (aMT6-s) levels and serum concentration interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α) interleukin-8 (IL-8).
Aging increases oxidative stress and inflammation. Melatonin counteracts inflammation apoptosis. This study investigated the possible protective effect of melatonin on inflammatory apoptotic response secondary to ischemia induced by blockade right middle cerebral artery (MCA) in aging male Wistar rats. Animals were subjected MCA obstruction. After 24 h or 7 days procedure, 14-month-old nontreated treated rats with a daily dose 10 mg/kg sacrificed left hippocampus cortex collected. Rats aged...
Abstract Introduction The deprivation of blood supply to an intestinal segment, followed by its subsequent restoration, triggers the condition known as ischaemia-reperfusion syndrome (i-IRI). Throughout this process, proinflammatory and oxidative mediators are produced, released, distributed via bloodstream, ultimately causing damage both locally systemically. Cannabidiol (CBD) is a molecule with antioxidant anti-inflammatory properties that regulate stress inflammatory states. aim study...