A5030896761- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Mesenchymal stem cell research
- Advanced MRI Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- MRI in cancer diagnosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Retinal Development and Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Osteoarthritis Treatment and Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Trigeminal Neuralgia and Treatments
- Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
Stanford University
2011-2025
Arvalis - Institut du Végétal
2024
New England Institute for Neurology and Headache
2021-2024
Hokkaido University Hospital
2021-2024
Neurological Surgery
2024
University of Pittsburgh Medical Center
2016-2024
Loma Linda University
2024
Loma Linda University Medical Center
2024
Stanford Medicine
2008-2023
Palo Alto University
2012-2019
Background and Purpose— Preclinical data suggest that cell-based therapies have the potential to improve stroke outcomes. Methods— Eighteen patients with stable, chronic were enrolled in a 2-year, open-label, single-arm study evaluate safety clinical outcomes of surgical transplantation modified bone marrow–derived mesenchymal stem cells (SB623). Results— All population (N=18) experienced at least 1 treatment-emergent adverse event. Six 6 serious events; 2 probably or definitely related...
Conventional angiography has been historically considered the gold standard for diagnosis of cervical artery dissection, but MR imaging/MR (MRA) and CT/CT (CTA) are commonly used noninvasive alternatives. The goal this study was to compare ability multidetector CT/CTA imaging/MRA detect common imaging findings dissection.Patients in data base our Stroke Center between 2003 2007 with dissections who had on initial work-up were reviewed retrospectively. Two neuroradiologists evaluated images...
A neuropeptide kills patient's motivation Chronic pain is not only extremely disturbing and unpleasant; it can also make people depressed demotivated. What causes these effects? Schwartz et al. discovered that chronic changes in the way a called galanin affects certain neurons brain region nucleus accumbens (see Perspective by Fields). Galanin influences variety of behaviors, including feeding aspects pain. In this case, depresses synaptic transmission at specific excitatory synapses. It...
Thrombolytic agents, including tenecteplase, are generally used within 4.5 hours after the onset of stroke symptoms. Information on whether tenecteplase confers benefit beyond is limited. We conducted a multicenter, double-blind, randomized, placebo-controlled trial involving patients with ischemic to compare (0.25 mg per kilogram body weight, up 25 mg) placebo administered 24 time that patient was last known be well. Patients had have evidence occlusion middle cerebral artery or internal...
The aim of this study was to evaluate the safety and clinical outcomes associated with stereotactic surgical implantation modified bone marrow-derived mesenchymal stem cells (SB623) in patients stable chronic ischemic stroke.
To determine whether chronic motor deficits secondary to traumatic brain injury (TBI) can be improved by implantation of allogeneic modified bone marrow-derived mesenchymal stromal/stem cells (SB623).This 6-month interim analysis the 1-year double-blind, randomized, surgical sham-controlled, phase 2 Stem Cell Therapy for Traumatic Brain Injury (STEMTRA) trial (NCT02416492) evaluated safety and efficacy stereotactic intracranial SB623 in patients with stable TBI. Patients this multicenter (n...
Abstract Preclinical osteoarthritis (OA) models are often employed in studies investigating disease-modifying OA drugs (DMOADs). In this study we present a comprehensive, longitudinal evaluation of pathogenesis rat model OA, including histologic and biochemical analyses articular cartilage degradation assessment subchondral bone sclerosis. Male Sprague-Dawley rats underwent joint destabilization surgery by anterior cruciate ligament transection partial medial meniscectomy. The contralateral...
While stable xenon CT (Xe-CT) cerebral blood flow (CBF) is an accepted standard for quantitative assessment of hemodynamics, the accuracy magnetic resonance perfusion-weighted imaging (PWI-MRI) unclear. The Improved PWI Methodology in Acute Clinical Stroke Study compares findings with Xe-CT CBF values patients experiencing symptomatic severe hypoperfusion.We compared mean transit time (MTT) and Tmax PWI-MRI corresponding 25 coregistered regions interest (ROIs) multiple sizes locations nine...
To develop a simple prognostic model to predict outcome at 1 month after acute basilar artery occlusion (BAO) with readily available predictors.The Basilar Artery International Cooperation Study (BASICS) is prospective, observational, international registry of consecutive patients who presented an symptomatic and radiologically confirmed BAO. We considered predictors hospital admission in multivariable logistic regression models poor (modified Rankin Scale [mRS] score 4-5 or death) month....
To evaluate a novel emergency department-based TIA triage system.We developed an approach to and management based on risk assessment using the ABCD(2) score in combination with early cervical intracranial vessel imaging. It was anticipated that this system would avoid hospitalization for majority of patients result low rate recurrent stroke. We hypothesized subsequent stroke among consecutively encountered managed be lower than predicted their ABCD2 scores.From June 2007 December 2009, 224...
To determine whether hospitalized mentally ill patients expose themselves to research with high risks more often than nonpsychiatric patients, the authors asked from both groups if they would be willing participate in a series of hypothetical studies. The did not agree studies either or low risk frequently patients. Both tended low-risk/high-benefit high-risk/low-benefit Although Brief Psychiatric Rating Scale scores clearly differentiated between psychiatric and psychopathology correlate...
Abstract Background Imbalances in the regulation of pro-inflammatory cytokines have been increasingly correlated with a number severe and prevalent neurodevelopmental disorders, including autism spectrum disorder, schizophrenia Down syndrome. Although several studies shown that potent effects on neural function, their role development is still poorly understood. In this study, we investigated link between abnormal cytokine levels using Xenopus laevis tadpole visual system, model frequently...
Although optimizing decisions between drives to avoid pain and obtain reward are critical for survival, understanding the neuronal circuit activity that regulates choice during approach-avoidance conflicts is limited. Here, we recorded in infralimbic (IL) cortex nucleus accumbens (NAc) an task. In this task, disruption of approach by a pain-predictive cue (PPC-avoidance) extinguished experience reinstated model chronic pain. IL-NAc circuit, distinct subpopulations neurons predicts extent...
Introduction: Except for vagal nerve stimulation, no treatment exists to restore function in chronic stroke patients. Several prior intracerebral stem cell trials were promising, but are not being further developed. Objective: NR1 is a human embryonic derived neural that improved motor-sensory rodent models, and was expanded produce GMP cryopreserved lots. The safety&efficacy of transplantation patients assessed over 12 months. Methods: Inclusion Criteria: 18-75 yo; 6-60 mos...
The optimal diagnostic evaluation for spontaneous intracerebral hemorrhage (ICH) remains controversial. In this retrospective study, we assessed the utility of early magnetic resonance imaging (MRI) in ICH diagnosis and management.Eighty-nine (72%) 123 patients with underwent a brain CT MRI within 30 days onset. Seventy mean age 62 ± 15 years were included. A stroke neurologist general neurologist, each blinded to final diagnosis, independently reviewed admission data initial head then...
Diffusion-weighted imaging (DWI) is recommended for the evaluation of transient ischemic attack. Perfusion can increase yield MRI in We evaluated automated bolus perfusion (the time when residue function reaches its maximum [TMax] and mean transit [MTT]) arterial spin labeling (ASL) sequences detection lesions patients with attack.We enrolled consecutive suspicion acute attack by multimodal within 36 hours symptom onset. Two independent raters assessed presence location blinded to clinical...
Traumatic brain injury (TBI) is frequently characterized by chronic motor deficits. Therefore, this clinical trial assessed whether intracranial implantation of allogeneic modified mesenchymal stromal (SB623) cells can improve deficits after TBI.
Activation of metabotropic glutamate receptors (mGluRs) has diverse effects on the functioning vertebrate synapses. The cellular mechanisms that underlie these changes, however, are largely unknown. role presynaptic mGluRs in modulating Ca(2+) dynamics and regulating neurotransmitter release was investigated at vestibulospinal-reticulospinal (VS-RS) synapse lamprey brain stem. Application specific Group I antagonist 7-(hydroxyimino) cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt)...
Abstract Purpose To test whether dynamic susceptibility contrast MRI‐based CBF measurements are improved with arterial input function (AIF) partial volume (PV) and nonlinear relaxivity correction, using a gold‐standard method, xenon computed tomography (xeCT). Materials Methods Eighteen patients cerebrovascular disease underwent xeCT MRI within 36 h. PV was measured as the ratio of area under AIF venous output (VOF) concentration curves. A correction applied to account for bulk blood (BB)....
Abstract Agricultural diseases are a major threat to sustainable food production. Yet, for many pathogens we know exceptionally little about their epidemiological and population dynamics, this knowledge gap is slowing the development of efficient control strategies. Here study genomics molecular epidemiology wheat powdery mildew, disease caused by biotrophic fungus Blumeria graminis forma specialis tritici (Bgt). We sampled Bgt two consecutive years, 2022 2023, from 22 countries in Europe...