A5017636370- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Congenital heart defects research
- Genetic factors in colorectal cancer
- CAR-T cell therapy research
- CNS Lymphoma Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Nausea and vomiting management
- Folate and B Vitamins Research
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Congenital Heart Disease Studies
- RNA modifications and cancer
- Biosimilars and Bioanalytical Methods
- Robotic Path Planning Algorithms
- Evolution and Genetic Dynamics
- Immunodeficiency and Autoimmune Disorders
- Metabolism and Genetic Disorders
- RNA and protein synthesis mechanisms
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Bacteriophages and microbial interactions
Duke University
2019-2024
Center for Genomic Science
2020
Dhirubhai Ambani Institute of Information and Communication Technology
2018
Indian Institute of Technology Bombay
2018
Session 3 of the 2021 Workshop Society for Hematopathology/European Association Haematopathology examined progression and transformation chronic lymphocytic leukemia/small lymphoma (CLL/SLL) B-cell prolymphocytic leukemia (B-PLL).
Session 2 of the 2021 Society for Hematopathology and European Association Haematopathology Workshop collected examples lineage infidelity transdifferentiation in B-lineage neoplasms, including after targeted therapy.Twenty cases were submitted. Whole-exome sequencing genome-wide RNA expression analysis available on a limited subsample.A diagnosis B-cell acute lymphoblastic leukemia (B-ALL) was rendered at least 1 biopsy from 13 patients. There case myeloid (AML); remaining 6 mature...
The 2021 Society for Hematopathology and European Association Haematopathology Workshop addressed the molecular cytogenetic underpinnings of transformation transdifferentiation in lymphoid neoplasms.
Modern molecular biology, owing much to the Human Genome Initiative, has elucidated many of genetic mechanisms underlying heritable metabolic disease. While use methods flourished in research laboratories, complexity and cost have limited their utility newborn screening. Newborn blood cards provide high quality DNA samples able reliable support highly multiplexed polymerase chain reactions (PCR). New manufacturing processes reduced microarray technology point where it is a practical tool for...
To summarize the conclusions of 2021 Society for Hematopathology/European Association Haematopathology workshop regarding transformations marginal zone lymphoma (MZL) and lymphoplasmacytic (LPL).Nineteen cases were submitted to this portion workshop. Additional studies performed in with sufficient material.Cases included splenic MZL (n = 4), diffuse red pulp small B-cell 2), nodal extranodal 1), LPL 8). The most common transformation was large (DLBCL), but others classic Hodgkin lymphoma,...
Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated (ABC) types. Advances in molecular methodologies have further refined the subclassification DLBCL, based recurrent genetic abnormalities. Here, we describe distinct case DLBCL that presented leukemic form. DNA sequencing targeting 275 genes revealed pathogenically relevant mutations
By replacing lost or dysfunctional myocardium, tissue regeneration is a promising approach to treat heart failure. However, the challenge of detecting bona fide limits validation potential regenerative factors. One method detect new cardiomyocytes multicolor lineage tracing with clonal analysis. Clonal analysis experiments can be difficult undertake, because labeling conditions that are too sparse lack sensitivity for rare events such as cardiomyocyte proliferation, and diffuse ability...
Abstract. H aving infected a bacterial cell, temperate phage has to make choice between (a) integrating itself into the genome, i.e. lysogeny , and (b) using machinery create multiple copies of lysing cell in process, lysis . In order maximize its long-term growth rate, phages need ensure that they do not wipe off their hosts. Temperate have been observed exhibit lysogenic propensities dependent on MoI (Multiplicity Infection), among other factors. We propose model estimate propensity opted...
To summarize cases submitted to the 2021 Society for Hematopathology/European Association Haematopathology Workshop under categories of progression Hodgkin lymphoma, plasmablastic myeloma, and plasma cell myeloma.The workshop panel reviewed 20 covered in this session. In addition, whole-exome sequencing (WES) whole-genome RNA expression analysis were performed on 10 cases, including 6 lymphoma 4 neoplasm cases.The included transformed or from various types B-cell with 1 exception, which had...
Introduction: Heart regeneration has been proposed as a treatment for heart failure. However, the challenge of detecting bona fide complicated validation potential regenerative factors. We sought to develop method quantifying cardiomyogenesis in mouse using multicolor lineage tracing. Hypothesis: hypothesized that tracing combination with modeling nearest neighbor distances could be used quantify clonal expansion cardiomyocytes (CMs) during growth and regeneration. Methods: Myh6- MerCreMer ;...
By replacing lost or dysfunctional myocardium, tissue regeneration is a promising approach to treat heart failure. However, the challenge of detecting bona fide limits validation potential regenerative factors. One method detect new cardiomyocytes multicolor lineage tracing with clonal analysis. Clonal analysis experiments can be difficult undertake, because labeling conditions that are too sparse lack sensitivity for rare events such as cardiomyocyte proliferation, and diffuse ability...