A5002654651- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Cardiomyopathy and Myosin Studies
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Cardiovascular Effects of Exercise
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- HER2/EGFR in Cancer Research
- Cardiac electrophysiology and arrhythmias
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Cardiac pacing and defibrillation studies
- Immunodeficiency and Autoimmune Disorders
- Genetic factors in colorectal cancer
- Cardiac Fibrosis and Remodeling
- Bioenergy crop production and management
- Research on Leishmaniasis Studies
Centro Cardiologico Monzino
2022-2025
Mylan (Switzerland)
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2023
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015-2022
IRCCS Eugenio Medea
2022
University of Milan
2012-2021
University Hospital Brno
2019
Kindai University Hospital
2019
Ospedale Maggiore
2019
Vita-Salute San Raffaele University
2013-2014
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) are still to be investigated. Here, we studied the functional significance druggability oncogenic lncRNA MALAT1 MM. Targeting by novel LNA-gapmeR antisense oligonucleotide antagonized MM cell proliferation triggered apoptosis both vitro vivo a murine xenograft model human Of note, antagonism downmodulated two major transcriptional activators proteasome subunit genes, namely NRF1 NRF2,...
Although many efforts have recently contributed to improve our knowledge of molecular pathogenesis multiple myeloma (MM), the role and significance long non-coding RNAs (lncRNAs) in plasma cells (PC) malignancies remains virtually absent. To this aim, we developed a custom annotation pipeline microarray data investigating lncRNA expression PCs from 20 monoclonal gammopathies undetermined significance, 33 smoldering MM, 170 36 extra-medullary MMs/plasma cell leukemia patients, 9 healthy...
Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all which are predisposing factors to fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response these mechanical cues through activation the Hippo transcriptional pathway. The objective present study was assess role cellular/nuclear straining forces acting in myofibroblast differentiation under...
// Marta Lionetti 1 , Marzia Barbieri 2 Katia Todoerti 3 Luca Agnelli Simona Marzorati Sonia Fabris Gabriella Ciceri Serena Galletti Giulia Milesi Martina Manzoni Mara Mazzoni 4 Angela Greco Giovanni Tonon 5 Pellegrino Musto Baldini 1,2 and Antonino Neri Department of Clinical Sciences Community Health, University Milan, Italy Hematology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Laboratory Pre-Clinical Translational Research, IRCCS-CROB, Referral Cancer Center...
Abstract Long non-coding RNAs (lncRNAs) represent a novel class of functional RNA molecules with an important emerging role in cancer. To elucidate their potential pathogenetic chronic lymphocytic leukemia (CLL), biologically and clinically heterogeneous neoplasia, we investigated lncRNAs expression prospective series 217 early-stage Binet A CLL patients 26 different subpopulations normal B-cells, through custom annotation pipeline microarray data. Our study identified 24-lncRNA-signature...
The prevalence of TP53 mutations greatly varies between tumor types; in multiple myeloma (MM) they were rarely detected at presentation, while increased frequency was reported with disease progression. Using next-generation sequencing, we analyzed exons 4-9 a large representative cohort comprising patients MM diagnosis and more aggressive forms plasma cell (PC) dyscrasia, identifying 4/129 (3%) MM, 6/24 (25%) primary PC leukemia, 2/10 (20%) secondary leukemia cases. A similar increase...
// Enrica Calura 1,* , Andrea Bisognin 2,* Martina Manzoni 3 Katia Todoerti 4 Elisa Taiana Gabriele Sales 1 Gareth J. Morgan 5 Giovanni Tonon 6 Nicola Amodio 7 Pierfrancesco Tassone Antonino Neri Luca Agnelli 3,** Chiara Romualdi 1,** and Stefania Bortoluzzi 2,** Department of Biology, University Padua, Italy 2 Molecular Medicine, Clinical Sciences Community Health, Milan, Hematology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Laboratory Pre-Clinical Translational...
Multiple myeloma (MM) is a clonal proliferation of bone marrow plasma cells characterized by highly heterogeneous genetic background and clinical course, whose pathogenesis remains largely unknown. Long ncRNAs (lncRNAs) are large class non-protein-coding RNA, involved in many physiological cellular genomic processes as well carcinogenesis tumor evolution. Although still its infancy, the role lncRNAs MM progressively expanding. Besides studies on selected candidates, expression at genome-wide...
Recent evidence indicates that protein kinase CK1α may support the growth of multiple myeloma (MM) plasma cells. Here, by analyzing a large cohort MM cases, we found high mRNA levels are virtually associated with all patients. Moreover, provided functional activity is essential for malignant cell survival even in protective niche generated co-cultures bone marrow stromal We demonstrated inactivation, while toxic cells, dispensable healthy B lymphocytes and Disruption function cells resulted...
Abstract Purpose: Multiple myeloma is a biologically heterogenous plasma-cell disorder. In this study, we aimed at dissecting the functional impact on transcriptome of gene mutations, copy-number abnormalities (CNA), and chromosomal rearrangements (CR). Moreover, applied geno-transcriptomic approach to identify specific biomarkers for personalized treatments. Experimental Design: We analyzed 514 newly diagnosed patients from IA12 release CoMMpass accounting mutations in multiple driver...
Abstract Multiple myeloma is a post-germinal center B-cell neoplasm, characterized by the proliferation of malignant bone marrow plasma cells, whose survival and sustained growth factors cytokines present in microenvironment. Among them, IL-6 triggers signal downstream its receptor, leading to activation JAK/STAT pathway. The atypical GTPase RhoU lays STAT3 transcription factor could be responsible for mediating effects on cytoskeleton dynamics. Here we demonstrate that RHOU heterogeneously...
The identification of deregulated microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in multiple myeloma (MM) has progressively added a further level complexity to MM biology. In addition, the cross-regulation between lncRNAs miRNAs begun emerge, theoretical experimental studies have demonstrated competing endogenous RNA (ceRNA) activity as natural miRNA decoys pathophysiological conditions, including cancer. Currently, information concerning lncRNA interplay is virtually absent. Herein,...
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IGF1R is emerging as an important gene in the pathogenesis of many solid and haematological cancers its over-expression has been reported frequently associated with aggressive disease chemotherapy resistance. In this study we performed investigation role expression a large representative prospective series 217 chronic lymphocytic leukaemia (CLL) patients enrolled multicentre O-CLL1 protocol (clinicaltrial.gov #NCT00917540). High was significantly IGHV unmutated (IGHV-UM) status (p<0.0001),...
Although the progression of chronic lymphocytic leukemia (CLL) requires cooperation microenvironment, exact cellular and molecular mechanisms involved are still unclear. We investigated interleukin (IL)-23 receptor (IL-23R)/IL-23 axis found that circulating cells from early-stage CLL patients with shorter time-to-treatment, but not those a more benign course, expressed defective form IL-23R complex lacking IL-12Rβ1 chain. However, both patient groups complete in tissue infiltrates could be...