Marco Agrifoglio
A5077733225- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Infective Endocarditis Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- Aortic aneurysm repair treatments
- Coronary Interventions and Diagnostics
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Vascular Procedures and Complications
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Infectious Aortic and Vascular Conditions
- Acute Myocardial Infarction Research
- Electrospun Nanofibers in Biomedical Applications
- Coronary Artery Anomalies
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Tissue Engineering and Regenerative Medicine
- Venous Thromboembolism Diagnosis and Management
- Cardiac Health and Mental Health
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
Centro Cardiologico Monzino
2016-2025
University of Milan
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2023
IRCCS Ospedale San Raffaele
2023
Vita-Salute San Raffaele University
2023
St. Michael's Hospital
2017
Sunnybrook Health Science Centre
2017
St. Paul's Hospital
2017
Ferrarotto Hospital
2017
Rabin Medical Center
2017
Due to bioprosthetic valve degeneration, aortic valve-in-valve (ViV) procedures are increasingly performed. There no data on long-term outcomes after ViV. Our aim was perform a large-scale assessment of survival and reintervention ViV.A total 1006 ViV performed more than 5 years ago [mean age 77.7 ± 9.7 years; 58.8% male; median STS-PROM score 7.3% (4.2-12.0)] were included in the analysis. Patients treated with Medtronic self-expandable valves (CoreValve/Evolut, Inc., Minneapolis, MN, USA)...
Mitral valve-in-valve (ViV) and valve-in-ring (ViR) are alternatives to surgical reoperation in patients with recurrent mitral valve failure after previous repair or replacement. Our aim was perform a large-scale analysis examining midterm outcomes ViV ViR.Patients undergoing ViR were enrolled the Valve-in-Valve International Data Registry. Cases performed between March 2006 2020. Clinical endpoints reported according Valve Academic Research Consortium (MVARC) definitions. Significant...
Background: Conversion of cardiac stromal cells into myofibroblasts is typically associated with hypoxia conditions, metabolic insults, and/or inflammation, all which are predisposing factors to fibrosis and heart failure. We hypothesized that this conversion could be also mediated by response these mechanical cues through activation the Hippo transcriptional pathway. The objective present study was assess role cellular/nuclear straining forces acting in myofibroblast differentiation under...
This experimental research describes sight translation by comparing it to simultaneous and consecutive interpreting. Since the beginning of interpreting research, has mostly been considered as a pedagogical exercise interpreters are rarely trained in this task per se. However, translation, performed under different conditions, these determine how cognitive resources managed what strategies adopted. The study compares performance six professional with view identifying particular constraints...
The heart contains c-kit+ progenitors that maintain cardiac homeostasis. Cardiac cells are multipotent and give rise to myocardial, endothelial smooth muscle cells, both in vitro vivo. C-kit+ have been thoroughly investigated for their stem cell activity, susceptibility stress conditions ageing, as well ability repair the infarcted heart. Recently, expression of mesenchymal (MSC) markers MSC differentiation potency reported progenitor cells. Based on this evidence, we hypothesized may...
Aims:The safety and efficacy of single vs. dual antiplatelet therapy (DAPT) in patients undergoing TAVI remain to be addressed.The aim our study was evaluate the usefulness a DAPT compared platelet with balloon-expandable prosthesis.Methods results: All consecutive enrolled ITER registry were included.Patients discharged aspirin alone those taking before after selection using propensity score matching.Subgroup analysis performed for on OAT.Prosthetic heart valve dysfunction at follow-up...
To evaluate feasibility, image quality and accuracy of a reduced contrast volume protocol for pre-procedural CT imaging in transcatheter aortic valve implantation (TAVI) using third generation wide array scanner.115 consecutive patients (51F, mean age 82.5 ± 6.2 y, BMI 26.7 3.6) referred TAVI were examined with wide-array scanner combined scan total amount 50 ml agent. A 4-point visual scale (4-1) was used to assess . Contrast attenuation values (HU) contrast-to-noise ratio (CNR) measured at...
Background Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due adverse remodeling caused by overproliferation of smooth muscle cells in intima layer, leading progressive bypass stenosis. We previously showed that cyclic strain deriving from exposure coronary flow induces expression matricellular protein thrombospondin‐1 human SV, promoting activation progenitor normally...
To determine whether the Trifecta bioprosthetic aortic valve produces postoperative haemodynamic results comparable with or better than those of Magna Ease bioprosthesis. We retrospectively reviewed medical records patients who had undergone replacement prostheses at eight European institutions between January 2011 and May 2013, analysed early performance by means echocardiography. A total 791 underwent (469 Ease, 322 Trifecta). Haemodynamic variables were evaluated on discharge during...
The aim of this multicentre study is to report the clinical experiences all patients undergoing transcatheter aortic valve implantation (TAVI) with a balloon-expandable device in Italy.The Italian Transcatheter balloon-Expandable Registry (ITER) real-world registry that includes who have undergone TAVI Sapien (Edwards Lifesciences, Irvine, CA, USA) bioprosthesis Italy since it became available practice. From 2007 2012, 1904 were enrolled undergo 33 centres. Outcomes classified according...
Background CD 34+ stem/progenitor cells are involved in vascular homeostasis and neovascularization of ischemic tissues. The number circulating stem is a predictive biomarker adverse cardiovascular outcomes diabetic patients. Here, we provide evidence that hyperglycemia can be "memorized" by the through epigenetic changes contribute to onset maintenance their dysfunction diabetes mellitus. Methods Results Cord-blood-derived exposed high glucose displayed increased reactive oxygen species...
Rationale: Despite the preferred application of arterial conduits, greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel artery disease (CAD). The objective present work was to address role mechanical forces activation maladaptive remodeling, a process determining progressive occlusion and recurrence ischemic heart disease. Methods: We employed custom bioreactor mimic shear wall mechanics human SV vascular conduits reproduce...
Transcatheter valve-in-valve implantation is an established therapy for high-risk patients with failed surgical aortic bioprosthesis. There are limited data comparing outcomes of using different transcatheter heart valves (THV).Patients included in the Valve-in-Valve International Data registry (VIVID) and treated self-expanding THV devices were analyzed centralized core laboratory blinded to clinical events. St. Jude Medical Portico versus Medtronic CoreValve compared a 1:2 fashion after...