A5019372137- 3D Printing in Biomedical Research
- Biosensors and Analytical Detection
- Microfluidic and Bio-sensing Technologies
- Cardiac and Coronary Surgery Techniques
- Characterization and Applications of Magnetic Nanoparticles
- Angiogenesis and VEGF in Cancer
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Electrostatics and Colloid Interactions
- Mosquito-borne diseases and control
- Digital Imaging for Blood Diseases
- Bioeconomy and Sustainability Development
- Tissue Engineering and Regenerative Medicine
- Phytoplasmas and Hemiptera pathogens
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrohydrodynamics and Fluid Dynamics
- Vector-borne infectious diseases
- Pluripotent Stem Cells Research
- Gastrointestinal motility and disorders
- Thermal Regulation in Medicine
- Malaria Research and Control
- Hydrogels: synthesis, properties, applications
- Electrowetting and Microfluidic Technologies
- Cerebrospinal fluid and hydrocephalus
- Spaceflight effects on biology
Politecnico di Milano
2020-2023
University Hospital in Halle
2023
Azienda Ospedaliera San Gerardo
2022
Rationale: Despite the preferred application of arterial conduits, greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel artery disease (CAD). The objective present work was to address role mechanical forces activation maladaptive remodeling, a process determining progressive occlusion and recurrence ischemic heart disease. Methods: We employed custom bioreactor mimic shear wall mechanics human SV vascular conduits reproduce...
Malaria remains the most important mosquito-borne infectious disease worldwide, with 229 million new cases and 409.000 deaths in 2019. The infection is caused by a protozoan parasite which attacks red blood cells feeding on hemoglobin transforming it into hemozoin. Despite WHO recommendation of prompt malaria diagnosis, quality microscopy-based diagnosis frequently inadequate while rapid diagnostic tests based antigens are not quantitative still affected non-negligible false...
This paper presents a custom, low-cost electronic system specifically designed for rapid and quantitative detection of the malaria parasite in blood sample. The exploits paramagnetic properties malaria-infected red cells (iRBCs) their magnetophoretic capture on surface silicon chip. A lattice nickel magnetic micro-concentrators embedded substrate concentrates iRBCs above coplanar gold microelectrodes separated by 3 μm through an impedance measurement. sensor is differential operation to...
The development of innovative diagnostic tests is fundamental in the route towards malaria eradication. Here, we discuss sorting capabilities an test for which allows quantitative and rapid detection all species. physical concept exploits paramagnetic property infected erythrocytes hemozoin crystals, magnetic fingerprints common to species, them undergo a selective magnetophoretic separation driven by field gradient competition with gravity. Upon separation, corpuscles concentrate at surface...
The search for new rapid diagnostic tests malaria is a priority developing an efficient strategy to fight this endemic disease, which affects more than 3 billion people worldwide. In study, we characterize systematically easy-to-operate lab-on-chip, designed the magnetophoretic capture of malaria-infected red blood cells (RBCs). method relies on positive magnetic susceptibility infected RBCs with respect plasma. A matrix nickel posts fabricated in silicon chip placed face down aimed at...
Hypothermia is a promising therapeutic strategy for severe vasospasm and other types of non-thrombotic cerebral ischemia, but its clinical application limited by significant systemic side effects. We aimed to develop an intraventricular device the controlled cooling cerebrospinal fluid, produce targeted hypothermia in affected hemisphere with minimal effect on temperature. An (acronym: V-COOL) was developed silico modelling, vitro testing, vivo proof-of-concept healthy Wistar rats (n = 42)....
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Our experience shows that using bioengineering approaches facilitates the understanding of vascular physio-pathological mechanisms and, in perspective, will speed up development new life-saving treatments. The use human samples, particularly operating room-derived which would have been otherwise discarded, is a very valuable approach. In line with 3Rs principles, this methodology worth cost being set and managed, wherever whenever possible
Despite the huge efforts for malaria eradication, this infectious disease still represents a critical issue worldwide, with 3.5 billion people at risk, 229 million new cases and 409.000 deaths in 2019. The infection is caused by Plasmodiun parasite which attacks red blood cells, feeds on hemoglobin transform it into hemozoin nanocrystals. In paper we report novel pan-malaria test (TMek), based paramagnetic properties of nanocrystals, allows automatic quantification infected cells (i-RBCs)...
In article 2004101, Marco Giacometti, Riccardo Bertacco and co-workers reported on a diagnostic tool (TMek) based paramagnetic properties of hemozoin nanocrystals in infected red blood cells (i-RBCs). Exploiting the competition between gravity magnetic forces, i-RBCs whole specimen are sorted electrically detected microchip. The findings indicate potential TMek as quantitative, stage-selective, rapid test for malaria. Cover designed by Tommaso Pravettoni Jonathan Barsotti.
A novel device to analyze the correlation between hydrodinamic stimuli and atherosclerosis advancement.
In vitro cell cultures represent a widespread methodology for pathophysiology studies with high benefit/cost ratio. We have developed and are validating TToP, novel, versatile, scalable culture system allowing compartmentalized cell/tissue the aim of mimicking human pathophysiological microenvironment tissue barriers.
A novel device to analyze the correlation between hydrodinamic stimuli and atherosclerosis advancement.