A5081652420- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Brain Tumor Detection and Classification
- Structural Load-Bearing Analysis
- Chemotherapy-induced cardiotoxicity and mitigation
- MicroRNA in disease regulation
- Calcium signaling and nucleotide metabolism
- Adenosine and Purinergic Signaling
- Structural Engineering and Vibration Analysis
- Civil and Structural Engineering Research
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Electrochemical sensors and biosensors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Congenital heart defects research
- Metabolism, Diabetes, and Cancer
- Electron Spin Resonance Studies
- Cancer, Stress, Anesthesia, and Immune Response
Institut des Maladies Métaboliques et Cardiovasculaires
2020-2024
Inserm
2020-2024
Université de Toulouse
2020-2023
Université Toulouse III - Paul Sabatier
2023
Centro Cardiologico Monzino
2018-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Abstract Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by progressive muscle weakness due to the absence of functional dystrophin. DMD patients also develop dilated cardiomyopathy (DCM). We have previously shown that ( mdx ) mice and a canine model (GRMD) exhibit abnormal intracellular calcium (Ca 2+ cycling related early‐stage pathological remodelling ryanodine receptor release channel (RyR2) on sarcoplasmic reticulum (SR) contributing age‐dependent DCM....
Background CD 34+ stem/progenitor cells are involved in vascular homeostasis and neovascularization of ischemic tissues. The number circulating stem is a predictive biomarker adverse cardiovascular outcomes diabetic patients. Here, we provide evidence that hyperglycemia can be "memorized" by the through epigenetic changes contribute to onset maintenance their dysfunction diabetes mellitus. Methods Results Cord-blood-derived exposed high glucose displayed increased reactive oxygen species...
Doxorubicin (Dox) is an effective anticancer molecule, but its clinical efficacy limited by strong cardiotoxic side effects. Lysosomal dysfunction has recently been proposed as a new mechanism of Dox-induced cardiomyopathy. However, to date, there paucity therapeutic approaches capable restoring lysosomal acidification and function in the heart. Methods: We designed novel poly(lactic-co-glycolic acid) (PLGA)-grafted silica nanoparticles (NPs) investigated their potential primary prevention...
Cardiac senescence is a typical chronic frailty condition in the elderly population, and cellular aging often associated with oxidative stress. The mitochondrial-membrane flavoenzyme monoamine oxidase A (MAO A) catalyzes deamination of neurotransmitters, its expression increases aged hearts. We produced recombinant human MAO variants at Lys305 that play key role O2 reactivity leading to H2O2 production. K305Q variant as active wild-type enzyme, whereas K305M K305S have 200-fold 100-fold...
Adult human cardiac mesenchymal progenitor cells (hCmPC) are multipotent resident populations involved in homeostasis and heart repair. Even if the mechanisms have not yet been fully elucidated, stem cell differentiation is guided by mitochondrial metabolism; however, approaches to identify hCmPC with enhanced stemness and/or capability for cellular therapy established. Here we demonstrated that hCmPCs sorted low high membrane potential (using a lipophilic cationic dye tetramethylrhodamine...
Bladder cancer is the 10th most common in world and has a high risk of recurrence metastasis. In order to sustain energetic needs, cells undergo complex metabolic adaptations, such as switch toward aerobic glycolysis, that can be exploited therapeutically. Reactive oxygen species (ROS) act key regulators reprogramming tumorigenesis, but sources ROS remain unidentified. Monoamine oxidases (MAOs) are mitochondrial enzymes generate H2O2 during breakdown catecholamines serotonin. These...
Introduction:The changing landscape of chromatin activity is a crucial factor in transcriptional gene regulation.It an important hallmark diseases, however it has not yet been investigated systematically human remodelled myocardium.Purpose: To address this gap knowledge, we aim to reveal genome-wide based on myocardial samples from patients either with acquired remodelling due severe aortic stenosis (AS) or inherited hypertrophic cardiomyopathy (HCM) mutated MYBPC3 gene; and donors without...