A5063863499- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Estrogen and related hormone effects
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Neutropenia and Cancer Infections
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- PI3K/AKT/mTOR signaling in cancer
- Hormonal Regulation and Hypertension
- Receptor Mechanisms and Signaling
- Gastrointestinal Tumor Research and Treatment
- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- Eosinophilic Disorders and Syndromes
- Economic and Financial Impacts of Cancer
- Vasculitis and related conditions
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Cancer-related Molecular Pathways
- Pharmaceutical Economics and Policy
Azienda Ospedaliera di Cosenza
2010-2021
Istituto di Biologia e Biotecnologia Agraria
2019
Roche (Italy)
2018
Azienda Sanitaria Locale CN2
2016-2018
Ospedale Annunziata di Cosenza
2011
University of Calabria
2003-2011
Weatherford College
2011
Pharmac
2011
Sunnybrook Health Science Centre
1994
University of Toronto
1994
A growing body of evidence concerning estrogen effects cannot be explained by the classic model hormone action, which involves binding to receptors (ERs) α and ERβ interaction steroid-receptor complex with specific DNA sequences associated target genes. Using c-fos proto-oncogene expression as an early molecular sensor action in ERα-positive MCF7 ER-negative SKBR3 breast cancer cells, we have discovered that 17β-estradiol (E2), two major phytoestrogens, genistein quercetin, stimulate through...
The growth of both normal and transformed epithelial cells the female reproductive system is stimulated by estrogens, mainly through activation estrogen receptor alpha (ERalpha), which a ligand-regulated transcription factor. selective ER modulator tamoxifen (TAM) has been widely used as an antagonist in breast tumor; however, long-term treatment associated with increased risk endometrial cancer. To provide new insights into potential mechanisms involved agonistic activity exerted TAM...
Background The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25HC) has been implicated a variety metabolic events including cholesterol homeostasis and atherosclerosis. 25HC is detectable human plasma after ingestion meal rich oxysterols following dietary challenge. addition, levels 25HC, have found to be elevated hypercholesterolemic serum. Methodology/Principal Findings Here, we demonstrate...
GPR30, also known as GPER, has been suggested to mediate rapid effects induced by estrogens in diverse normal and cancer tissues. Hypoxia is a common feature of solid tumors involved apoptosis, cell survival, proliferation. The response low oxygen environment mainly mediated the hypoxia-inducible factor named HIF-1α, which activates signaling pathways leading adaptive mechanisms tumor cells. Here, we demonstrate that hypoxia induces HIF-1α expression, turn mediates up-regulation GPER its...
Global DNA hypomethylation affecting repeat sequences has been reported in different cancer types. Herein, we investigated the methylation levels of repetitive elements chronic lymphocytic leukemia (CLL), their correlation with major cytogenetic and molecular features, clinical relevance predicting therapy-free survival (TFS). A quantitative bisulfite-PCR Pyrosequencing method was used to evaluate Alu, long interspersed nuclear elements-1 (LINE-1) satellite-α (SAT-α) 77 untreated early-stage...
Previous epidemiological reports have suggested that red wine intake is associated with beneficial health effects due to the ability of certain phytochemical components exert estrogen-like activity. It has been also documented estrogens induce proliferation hormone-dependent breast cancer cells by binding and transactivating estrogen receptor (ER) α, which in turn interacts responsive DNA sequences located within promoter region target genes. In order provide further insight into positive...
The molecular mechanisms involved in adrenocortical tumorigenesis are still not completely understood. In this study, using the H295R cell line as a model system, we investigated role of estrogens and estrogen receptor (ER) α ERβ growth regulation tumors. We demonstrated that cells able to convert androgens by constitutive expression active cytochrome P450 aromatase protein express greater extent than ERα. Moreover, physiological concentrations 17β-estradiol (E 2 ) determined an increase...
Abstract Aims: Using a model of isolated and Langendorff‐perfused rat heart we analysed whether activation β 3 ‐adrenergic receptors (β ‐ARs) influences ventricular lusitropic performance. We also focused on the NOS/NO/cGMP/PKG cascade as signal transduction mechanism. Methods: Hearts were treated with increasing concentrations (from 10 −12 to −6 m ) BRL 37344 , selective ‐AR agonist, cardiac performance was evaluated by analysing both parameters coronary motility. Cardiac preparations...
Highly homologous B-cell receptors, characterized by non-random combinations of immunoglobulin heavy-chain variable (IGHV) genes and complementarity determining region-3 (HCDR3), are expressed in a recurrent fraction patients affected chronic lymphocytic leukemia (CLL). We investigated the IGHV status 1131 productive IG rearrangements from panel 1126 CLL multicenter Italian study group, correlated presence class HCDR3 stereotyped subsets with major cytogenetic alterations evaluated FISH,...
The role of oestrogens in the development prostate cancer is poorly understood. However, a large body evidence has suggested that oestrogenic hormones may be involved prostatic malignancy. localization oestrogen receptor beta (ERbeta) secretory epithelium human raised intriguing possibility action could mediated, at least part, by this during process carcinogenesis. Hence, specific interference with oestrogen-activated and ERbeta-mediated transcriptional activity open new issues endocrine...
Abstract Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by recurrent chromosomal aberrations of prognostic significance. We aimed to evaluate the potential multiplex ligation‐dependent probe amplification (MLPA) assay detect genomic alterations in CLL. Highly purified (>90%) peripheral mononuclear CD19+ cell populations from 100 untreated CLL patients (pts) early stage (Binet A) were included this study. All samples investigated fluorescence situ...
Environmental contamination with a variety of industrial products has been associated developmental and reproductive abnormalities in wildlife species. Increasing evidence suggested that bisphenol A (BPA) 4-nonylphenol (NPH), two major endocrine-disrupting chemicals, might be responsible for adverse effects on humans as consequence ubiquitous use together potential oestrogen-like activity. To provide insight into the nature BPA NPH, their ability to activate reporter gene construct via an...