A5088969006- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Neuropeptides and Animal Physiology
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Antioxidant Activity and Oxidative Stress
- Protein Hydrolysis and Bioactive Peptides
- Physiological and biochemical adaptations
- Estrogen and related hormone effects
- Nicotinic Acetylcholine Receptors Study
- Regulation of Appetite and Obesity
- Hormonal Regulation and Hypertension
- Chemotherapy-induced cardiotoxicity and mitigation
- Redox biology and oxidative stress
- Diet and metabolism studies
- Selenium in Biological Systems
- Cellular transport and secretion
- Neurobiology and Insect Physiology Research
- Phytochemicals and Antioxidant Activities
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Electron Spin Resonance Studies
- Renin-Angiotensin System Studies
- Biochemical effects in animals
- Analytical Chemistry and Sensors
University of Calabria
2016-2025
Istituto Nazionale per le Ricerche Cardiovascolari
2010-2024
University of Pavia
2022
National Research Council
2015
University of Palermo
2007
Inserm
2007
Université de Strasbourg
2007
University of Turin
2007
Sapienza University of Rome
2006
San Raffaele University of Rome
2006
High chromogranin-A (CgA) levels were observed in patients with heart failure but its source remained uncertain. We evaluated whether CgA is produced by myocardium and might affect myocardial function. measured plasma performed immunohistochemistry anti-CgA antibodies on biopsies 40 dilated cardiomyopathy (DCM) 20 hypertrophic (HCM). Surgical specimens from DCM HCM used for PCR ELISA. The presence of CgA-derived fragments was gel-filtration HPLC their effects cardiac performance assessed...
Circulating levels of catestatin (Cts; human chromogranin A352–372) decrease in the plasma patients with essential hypertension. Genetic ablation A (Chga) gene mice increases blood pressure and pretreatment Chga-null Cts prevents elevation, indicating a direct role preventing This notable vasoreactivity prompted us to test cardiovascular effects mechanisms action wild-type (WT) naturally occurring variants (G364S-Cts P370L-Cts) on myocardial coronary functions. The actions WT-Cts were...
Background The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25HC) has been implicated a variety metabolic events including cholesterol homeostasis and atherosclerosis. 25HC is detectable human plasma after ingestion meal rich oxysterols following dietary challenge. addition, levels 25HC, have found to be elevated hypercholesterolemic serum. Methodology/Principal Findings Here, we demonstrate...
Abstract Aim Selenoprotein T (SelT or SELENOT ) is a novel thioredoxin‐like enzyme whose genetic ablation in mice results early embryonic lethality. SelT exerts an essential cytoprotective action during development and after injury through its redox‐active catalytic site. This study aimed to determine the expression regulation of mammalian heart normal pathological conditions evaluate cardioprotective effect SelT‐derived peptide, SelT43‐52( PSELT encompassing redox motif which key function,...
Autism Spectrum Disorder (ASD) is increasing, but its complete etiology still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, administered BTBR T+ Itpr3tf/J (BTBR) C57BL/6J (C57) mice reduced social deficits (p = 0.002), repetitive < 0.001) memory impairments BTBR. Behavioral effects were...
Inspired by the recent advancements in understanding binding mode of sulfonylurea-based NLRP3 inhibitors to sensor protein, we developed new replacing central sulfonylurea moiety with different heterocycles. Computational studies evidenced that some designed compounds were able maintain important interaction within NACHT domain target protein similarly most active inhibitors. Among studied compounds, 1,3,4-oxadiazol-2-one derivative 5 (INF200) showed promising results being prevent...
The use of Doxorubicin (Dox), a frontline drug for many cancers, is often complicated by dose-limiting cardiotoxicity in approximately 20% patients. G-protein estrogen receptor GPER/GPR30 mediates action as the cardioprotection under certain stressful conditions. For instance, GPER activation selective agonist G-1 reduced myocardial inflammation, improved immunosuppression, triggered pro-survival signaling cascades, mechanical performance, and infarct size after ischemia/reperfusion (I/R)...