A5040533991- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Neurobiology and Insect Physiology Research
- Stress Responses and Cortisol
- Biochemical effects in animals
- Regulation of Appetite and Obesity
- Zebrafish Biomedical Research Applications
- Adipose Tissue and Metabolism
- Olfactory and Sensory Function Studies
- Estrogen and related hormone effects
- Physiological and biochemical adaptations
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Effects and risks of endocrine disrupting chemicals
- Heat shock proteins research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Gut microbiota and health
- Neuroscience of respiration and sleep
- Diet and metabolism studies
- Phytoestrogen effects and research
University of Calabria
2013-2024
University of Turin
1994
Autism Spectrum Disorder (ASD) is increasing, but its complete etiology still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, administered BTBR T+ Itpr3tf/J (BTBR) C57BL/6J (C57) mice reduced social deficits (p = 0.002), repetitive < 0.001) memory impairments BTBR. Behavioral effects were...
SummaryBackgroundAn increasing amount of evidence suggests that migraine is a response to cerebral energy deficiencies or oxidative stress levels exceed antioxidant capacity. Current pharmacological options are inadequate in treating patients with chronic migraine, and growing interest focuses on nutritional approaches as non-pharmacological treatments. The ketogenic diet, mimicking fasting leads an elevation ketone bodies, therapeutic intervention targeting metabolism has recently shown...
The isolation of the G-protein-coupled receptor 30 (GPR30), an orphan membrane unrelated to nuclear estrogen receptors (ERs), has become a key factor towards unraveling rapid action. This together with cellular signaling intermediaries, i.e., extracellular signal-dependent kinases 1 and 2, may promote neuronal proliferation differentiation activities. In present study, evident gene expression pattern GPR30 characterized postnatal 7 (young) 60 (adult) days age hamsters as shown by its...
It has now been established that a large number of man-made and natural chemicals are capable interfering with the action hormones. In this category "endocrine disruptors" such as herbicide atrazine, when administered at ecological low doses (1 or 100 μg/kg per day) from gestational day 14 to postnatal 21, provided clear dimorphic neurodegenerative pattern in some brain areas domestic mouse (Mus musculus). Indeed, high concentration (100 respect induced relevant neuronal damage...
Abstract The neuropeptides hypocretins/orexins (ORX) are known to control state‐dependent activities such as sleep–wakefulness, energy homeostasis, thermoregulation, and maternal behaviors. To date, interests regarding environmental‐related ORX‐ergic neuronal functions have dealt with mammals; only recently is attention beginning be directed toward aquatic vertebrates. Here, photoperiod‐dependent effects of ORX‐A on behavioral, neurodegenerative transcriptional were evaluated in some...
Common environmental contaminants such as heavy metals and pesticides pose serious risks to behavioral neuroendocrine functions of many aquatic organisms. In the present study, we show that metal cadmium pesticide endosulfan produce effects through an interaction specific cerebral histamine receptor subtypes in teleost ornate wrasse (Thalassoma pavo). Treatment this with toxic levels for 1 week was sufficient induce abnormal swimming movements, whereas reduced feeding behaviors were provoked...
Abstract The modulatory actions of GABA A receptor subunits are crucial for morphological and transcriptional neuronal activities. In this study, growth hamster hippocampal neurons on biohybrid membrane substrates allowed us to show the first time that two major α (α 2,5 ) capable early shaping plus expression differences some main cytoskeletal factors (GAP‐43, neurotrophin––BDNF) Gluergic subtypes. a case inverse 5 agonist (RY‐080) seemed account reduction dendritic length at DIV7, very...
Recently, considerable interest has been aroused by the specific actions of bisphenol A (BPA). The present investigation represents a first study dealing with interaction BPA biologically more active somatostatin receptor subtype (sst(2)) in rat limbic circuit. After treating pregnant female Sprague-Dawley rats two doses (400 microg/kg/day; 40 microg/kg/day) BPA, binding activity above was evaluated some regions offspring. higher dose proved to be effective one, as demonstrated elevated...
The neurotoxic 3-nitropropionic acid (3-NP), a freckled milk vetch-derived inhibitor of mitochondrial enzymatic processes that is capable mimicking the typical pathological features neurodegenerative disorders, behaved in differentiated manner hibernating rodent (hamster) with respect to nonhibernating (rat). Treatment two rodents both an acute and chronic 3-NP dose supplied deleterious neuronal effects due distinct histamine receptor (H<sub>n</sub>R) transcriptional activities, especially...
Abstract Background The availability of oxygen is a limiting factor for neuronal survival since low levels account not only the impairment physiological activities such as sleep-wake cycle, but above all ischemic-like neurodegenerative disorders. In an attempt to improve our knowledge concerning type molecular mechanisms operating during stressful states like those hypoxic conditions, attention was focused on eventual transcriptional alterations some key AMPAergic silent receptor subtypes...