A5027761018- Composite Structure Analysis and Optimization
- Structural Load-Bearing Analysis
- Estrogen and related hormone effects
- Structural Analysis and Optimization
- Numerical methods in engineering
- Structural Health Monitoring Techniques
- Advanced Numerical Analysis Techniques
- Topology Optimization in Engineering
- Vibration and Dynamic Analysis
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Structural Analysis of Composite Materials
- Structural Behavior of Reinforced Concrete
- Seismic Performance and Analysis
- Dynamics and Control of Mechanical Systems
- Masonry and Concrete Structural Analysis
- Probabilistic and Robust Engineering Design
- Advanced Numerical Methods in Computational Mathematics
- Elasticity and Material Modeling
- Aeroelasticity and Vibration Control
- Structural Response to Dynamic Loads
- Receptor Mechanisms and Signaling
- Retinoids in leukemia and cellular processes
- Contact Mechanics and Variational Inequalities
- Crystallization and Solubility Studies
University of Calabria
2015-2024
University of Calabar
2014
Azienda Ospedaliera di Cosenza
2010-2011
Weatherford College
2011
I.R.C.C.S. Oasi Maria SS
1996
Abstract Estrogens play a crucial role in the development of ovarian tumors; however, signal transduction pathways involved hormone action are still poorly defined. The orphan G protein–coupled receptor 30 (GPR30) mediates nongenomic signaling 17β-estradiol (E2) variety estrogen-sensitive cancer cells through activation epidermal growth factor (EGFR) pathway. Whether estrogen α (ERα) also contributes to GPR30/EGFR is less understood. Here, we show that, ERα-positive BG-1 cells, both E2 and...
The paper presents an automated procedure for deriving fragility curves typological masonry aggregates, named META-FORMA-XL (MEchanical-Typological Approach FOR Masonry Aggregates – X Local). topic deals with the urban-scale seismic vulnerability analysis, which can provide powerful information developing risk mitigation plans and implementing strategies reducing expected losses. However, when buildings in aggregate are analysed, many issues arise, related to lack of data, complexity...
The higher incidence of thyroid carcinoma (TC) in women during reproductive years compared with men and the increased risk associated therapeutic use estrogens have suggested a pathogenetic role exerted by these steroids development TC. In present study, we evaluated potential 17β-estradiol (E2), genistein (G), 4-hydroxyta-moxifen (OHT) to regulate expression diverse estrogen target genes proliferation human WRO, FRO, ARO cells, which were used as model system. We ascertained that cells are...
Fibroblasts are the principal cellular component of connective tissue and associated with cancer cells at all stages tumor progression. Structural functional contributions fibroblasts to growth, survival, invasive capacity beginning emerge. In breast carcinoma, approximately 80% stromal termed cancer-associated (CAF) thought manifest an activated phenotype that promotes cell proliferation growth metastatic sites similar primary tumor. this report, we show CAFs respond physiologic...
Different cellular receptors mediate the biological effects induced by estrogens. In addition to classical nuclear estrogen (ERs)-α and -β, also signals through seven-transmembrane G-protein-coupled receptor (GPR)-30. Using as a model system SkBr3 BT20 breast cancer cells lacking ER, regulation of GPR30 expression 17β-estradiol, selective ligand G-1, IGF-I, epidermal growth factor (EGF) was evaluated. Transient transfections with an plasmid encoding short 5′-flanking sequence gene revealed...
BackgroundAtrazine, one of the most common pesticide contaminants, has been shown to up-regulate aromatase activity in certain estrogen-sensitive tumors without binding or activating estrogen receptor (ER). Recent investigations have demonstrated that orphan G-protein–coupled 30 (GPR30), which is structurally unrelated ER, mediates rapid actions 17β-estradiol and environmental estrogens.ObjectivesGiven ability atrazine exert estrogen-like cancer cells, we evaluated potential signal through...
The pesticide atrazine does not bind to or activate the classical estrogen receptor (ER), but it up-regulates aromatase activity in estrogen-sensitive tumor cells. G protein (GPR30/GPER) has been reported be involved certain biological responses endogenous estrogens and environmental compounds exerting estrogen-like activity.
In this paper, a hybrid variational framework for the Virtual Element Method (VEM) is proposed and family of polygonal elements plane elasticity developed. Under specific assumptions, it proved that minimization Total Potential Energy projection operation typical enhanced VEM can be deduced from stationary condition Hellinger–Reissner mixed functional. Since designed regarded as either or finite elements, they are named Hybrid (HVEM). The primary variables displacements along element...
What we call the implicit corotational method is proposed as a tool to obtain geometrically exact nonlinear models for structural elements, such beams or shells, undergoing finite rotations and small strains, starting from basic solutions three-dimensional Cauchy continuum used in corresponding linear modelings.The idea use local description decompose deformation gradient stretch part followed by rigid rotation.Referring this frame can derive, stress tensor provided elasticity, an accurate...
Abstract The paper presents a mechanical-based framework for the evaluation of local-scale seismic fragility curves. approach is oriented to vulnerability assessment unreinforced masonry buildings and makes use basic exposure data easily obtained from survey or available in existing database. An efficient finite element model static nonlinear analyses are employed assess structural behaviour. curves evaluated using Monte Carlo simulations that allow account uncertainties propagation....
A plasticity formulation for the Hybrid Virtual Element Method (HVEM) is presented. The main features include use of an energy norm VE projection, a high-order divergence-free interpolation stresses and piecewise constant plastic multipliers within element subdomains. HVEM does not require any stabilization term, unlike classical VEM formulations which are affected by choice parameters. algorithmic tangent matrix derived consistently analytically. standard strain-driven Backward-Euler time...
Summary The Koiter method recovers the equilibrium path of an elastic structure using a reduced model, obtained by means quadratic asymptotic expansion finite element model. Its main feature is possibility efficiently performing sensitivity analysis including posteriori effects imperfections in nonlinear equations. state‐of‐art treatment geometrical accurate only for small imperfection amplitudes and linear pre‐critical behaviour. This work enlarges validity to wider range practical problems...