A5026956525- Adipose Tissue and Metabolism
- Selenium in Biological Systems
- Chemotherapy-induced cardiotoxicity and mitigation
- Receptor Mechanisms and Signaling
- Hormonal Regulation and Hypertension
- Phytochemicals and Antioxidant Activities
- Redox biology and oxidative stress
- Diet and metabolism studies
- Natural Antidiabetic Agents Studies
- Regulation of Appetite and Obesity
- Apelin-related biomedical research
- Adipokines, Inflammation, and Metabolic Diseases
- Neuroscience and Neuropharmacology Research
- Pituitary Gland Disorders and Treatments
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Nitric Oxide and Endothelin Effects
- Long-Term Effects of COVID-19
- Cardiovascular Function and Risk Factors
- Pharmacology and Obesity Treatment
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Pulmonary Hypertension Research and Treatments
- Inflammasome and immune disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
University of Calabria
2016-2025
Istituto Nazionale per le Ricerche Cardiovascolari
2024
Inserm
2018
Université de Rouen Normandie
2018
Différenciation et Communication Neuronale et Neuroendocrine
2018
Normandie Université
2018
Roche (Canada)
2006
Centre Hospitalier Universitaire de Grenoble
2006
Catholic University of America
1992
Università Cattolica del Sacro Cuore
1976-1990
Abstract Aim Selenoprotein T (SelT or SELENOT ) is a novel thioredoxin‐like enzyme whose genetic ablation in mice results early embryonic lethality. SelT exerts an essential cytoprotective action during development and after injury through its redox‐active catalytic site. This study aimed to determine the expression regulation of mammalian heart normal pathological conditions evaluate cardioprotective effect SelT‐derived peptide, SelT43‐52( PSELT encompassing redox motif which key function,...
Autism Spectrum Disorder (ASD) is increasing, but its complete etiology still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, administered BTBR T+ Itpr3tf/J (BTBR) C57BL/6J (C57) mice reduced social deficits (p = 0.002), repetitive < 0.001) memory impairments BTBR. Behavioral effects were...
Inspired by the recent advancements in understanding binding mode of sulfonylurea-based NLRP3 inhibitors to sensor protein, we developed new replacing central sulfonylurea moiety with different heterocycles. Computational studies evidenced that some designed compounds were able maintain important interaction within NACHT domain target protein similarly most active inhibitors. Among studied compounds, 1,3,4-oxadiazol-2-one derivative 5 (INF200) showed promising results being prevent...
The use of Doxorubicin (Dox), a frontline drug for many cancers, is often complicated by dose-limiting cardiotoxicity in approximately 20% patients. G-protein estrogen receptor GPER/GPR30 mediates action as the cardioprotection under certain stressful conditions. For instance, GPER activation selective agonist G-1 reduced myocardial inflammation, improved immunosuppression, triggered pro-survival signaling cascades, mechanical performance, and infarct size after ischemia/reperfusion (I/R)...
Cardiac lipotoxicity is an important contributor to cardiovascular complications during obesity. Given the fundamental role of endoplasmic reticulum (ER)-resident Selenoprotein T (SELENOT) for cardiomyocyte differentiation and protection regulation glucose metabolism, we took advantage a small peptide (PSELT), derived from SELENOT redox-active motif, uncover mechanisms through which PSELT could protect cardiomyocytes against lipotoxicity. To this aim, modeled cardiac by exposing H9c2...
G protein-coupled estrogen receptor (GPER) is an expressed in the cardiovascular system. G1, a selective GPER ligand, exerts effects through activation of PI3K-Akt pathway and Notch signaling normotensive animals. Here we investigated whether G1/GPER interaction involved limitation infarct size, improvement post-ischemic contractile function female spontaneous hypertensive rat (SHR) hearts. In this model, also studied key components survival pathway, namely PI3K-Akt, Nitric Oxide Synthase...
Aim: To study the expression of histone methyltransferase SMYD1 in white adipose tissue (WAT) and brown during differentiation preadipocytes to beige phenotypes. Methods: C57BL/6J mice fed a high-fat diet (and exposed cold) 3T3-L1 cells stimulated differentiate into adipocytes were used. Results: increased WAT cold-exposed mice, suggesting its role thermogenesis. was higher than adipocytes, silencing leads decrease mitochondrial content Pgc-1α expression. Conclusion: These data suggest novel...
Abstract Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute protection. However, its action in chronic settings dysfunction is not understood. Here, we investigated role SELENOT pathophysiology HF: (i) by designing small peptide (PSELT), recapitulating activity via redox site, assessed beneficial preclinical model HF [aged spontaneously hypertensive...