A5059152225- Nitric Oxide and Endothelin Effects
- Physiological and biochemical adaptations
- Aquaculture Nutrition and Growth
- Renin-Angiotensin System Studies
- Environmental Toxicology and Ecotoxicology
- Receptor Mechanisms and Signaling
- Long-Term Effects of COVID-19
- Estrogen and related hormone effects
- High Altitude and Hypoxia
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Mercury impact and mitigation studies
- Ion channel regulation and function
- Microplastics and Plastic Pollution
- Genetics, Aging, and Longevity in Model Organisms
- Fish Ecology and Management Studies
- Birth, Development, and Health
- Respiratory Support and Mechanisms
- Lung Cancer Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Forensic and Genetic Research
- Pharmacological Effects of Natural Compounds
- Lung Cancer Treatments and Mutations
- COVID-19 Clinical Research Studies
University of Calabria
2016-2025
Neuroscience Institute
2025
Sapienza University of Rome
2016-2024
Policlinico Umberto I
2012-2024
University of Helsinki
2022
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2020
Azienda Ospedaliera di Valtellina e Valchiavenna
2015
Massachusetts General Hospital
2007-2010
Harvard University
2007
University of Pisa
1999
Little is known on the burden of co-infections and superinfections in a specific setting such as respiratory COVID-19 sub-intensive care unit. This study aims to (i) assess prevalence concurrent unit, (ii) evaluate risk factors for development (iii) impact in-hospital mortality.
Although an increased oxidative stress has been associated with several pathologies, predictive value of circulating biomarkers remains poorly understood. It demonstrated that pathologies underestimated in women, including cardiovascular diseases, develop differently by gender. In this study, conducted on 195 healthy volunteers, we assessed the putative gender difference prooxidant and antioxidant status. Our results were successful demonstrating a significant between sexes, whereas no was...
Abstract The metabotropic glutamate receptor subtype 5 (mGluR5) has been reported to be implicated in various neurological disorders the central nervous system.To investigate physiological and pathological functions of mGluR5, noninvasive imaging a living body with PET technology an mGluR5‐specific radiotracer is urgently needed. Here, we report synthesis 3‐[ 18 F]fluoro‐5‐(2‐pyridinylethynyl)benzonitrile ([ F]FPEB) through convenient thermal reaction as highly specific for mGluR5. precursor...
Obesity is a potent risk factor for kidney disease as it increases the possibility of developing diabetes and hypertension, has direct impact on development chronic end-stage renal disease. In this study, we tested effect bergamot polyphenolic fraction in cafeteria with diet-fed rats, an excellent experimental model studying human metabolic syndrome, able to induce severe obesity insulin resistance high plasma triglyceride levels more efficiently than traditional lard-based high-fat diet...
We propose an unobtrusive, wearable, and wireless system for the pre-screening follow-up in domestic environment of specific sleep-related breathing disorders. This group diseases manifests with episodes apnea hypopnea central or obstructive origin, it can be disabling, several drawbacks that interfere daily patient life. The gold standard their diagnosis grading is polysomnography, which a time-consuming, scarcely available test many wired electrodes disseminated on body, requiring...
During chronic kidney disease, the progressive deterioration of renal function induces several biological/clinical dysfunctions, including enhancement synthesis inflammation/oxidative stress mediators. Impaired is an independent cardiovascular risk factor; indeed, complications dominate landscape both disease and end-stage disease. The aim this study to explore correlation between global oxidative balance in hemodialysis patients inflammatory markers events. Using photometric tests, explored...
Plastic is everywhere-increasing evidence suggests that plastic pollution ubiquitous and persistent in ecosystems worldwide. Microplastic marine environments particularly insidious, as small fragmentation can increase interaction with biota food chain access. Of particular concern the Mediterranean Sea, which has become a large area of accumulation debris, including microplastics, whose polymeric composition still largely unknown. In this study, we analyzed composition, particle size...
Abstract Purpose OSAS is a syndrome that often presents clinically differently between men and women. The aim of this study was to assess the clinical presentation, nocturnal home sleep cardiorespiratory monitoring therapeutic adherence CPAP in both sexes identify most frequent patterns. Methods Data from first visit, follow-up visit 74 OSA patients were collected. Exclusion criteria included other respiratory and/or neuromuscular diseases (including Obesity hypoventilation syndrome)...
Recent evidence supports the hypothesis of an association between gut microbiota and pathogenesis retinal eye diseases, suggesting existence a gut-eye axis. However, no data are available on possible effect optic nerve fiber maturation myelin development. We investigated impact nerves collected from neonatal young adult germ-free (GF), gnotobiotic (stably colonized with 12 bacteria strains, OMM12) control (colonized complex microbiota, CGM) mice, by performing stereological...
In recent years, microplastic pollution has become one of the major global concerns and represents a complex, multidimensional, multisectoral reality. The considerable existing data relating to in matrices such as water soil suggests that microplastics are widespread globally, but there several knowledge gaps regarding their actual distribution mostly remote locations far from sources. this review we examine current on Antarctic continent. Antarctica, unique continent not permanently...
Mercury (Hg) is a highly hazardous pollutant widely used in industrial, pharmaceutical and agricultural fields. found the environment several forms, elemental, inorganic (iHg) organic, all of which are toxic. Considering that liver organ primarily involved regulation metabolic pathways, homeostasis detoxification we investigated morphological ultrastructural effects Danio rerio after 96 h exposure to two low HgCl2 concentrations (7.7 38.5 μg/L). We showed short-term very iHg severely affects...
Antarctica is the continent with lowest local human impact; however, it susceptible to pollution from external sources. Emerging pollutants such as perfluoroalkyl substances pose an increasing threat this environment and therefore require more in-depth investigations understand their environmental fate biological impacts. The present study focuses on expression analysis at transcriptional level of genes coding for four antioxidant enzymes (sod1, sod2, gpx1, gpx4) in liver kidney Antarctic...
Degeneration of dopaminergic neurons the substantia nigra pars compacta is a cardinal feature Parkinson9s disease (PD). Although uncertain, pathology has been suggested to derive from malfunction complex interaction between and metabotropic glutamate receptors (mGluRs). To further address this issue, we investigated imaging profile expression dopamine D<sub>2</sub> mGluRs in classic parkinsonian rodent model induced by toxin 6-hydroxydopamine. <b>Methods:</b> Adult male Sprague–Dawley rats...
Abstract Aims: Using a model of isolated and Langendorff‐perfused rat heart we analysed whether activation β 3 ‐adrenergic receptors (β ‐ARs) influences ventricular lusitropic performance. We also focused on the NOS/NO/cGMP/PKG cascade as signal transduction mechanism. Methods: Hearts were treated with increasing concentrations (from 10 −12 to −6 m ) BRL 37344 , selective ‐AR agonist, cardiac performance was evaluated by analysing both parameters coronary motility. Cardiac preparations...
The main target of primary prevention is the identification cardiovascular risk factors aimed at reducing adverse impact modifiable factors, such as lifestyle and pharmacological treatments. In humans, an alteration oxidative status has been associated with several pathologies, including diabetes diseases. However, prognostic relevance circulating stress biomarkers remains poorly understood. Our study explored, in a healthy population ( n = 322), relationship between factors. Here, we were...
Caloric restriction (CR) represents a powerful intervention for extending healthspan and lifespan in several animal models, from yeast to primates. Additionally, humans, CR has been found induce cardiometabolic adaptations associated with improved health. In this study, we evaluated an aged obese rat model the effect of long-term (6 months) caloric (−40%) on oxidative/inflammatory balance order investigate underlining mechanisms. plasma, analyzed oxidative by photometric tests...