A5103531979- Protease and Inhibitor Mechanisms
- Semiconductor Lasers and Optical Devices
- Photonic and Optical Devices
- Semiconductor Quantum Structures and Devices
- Atherosclerosis and Cardiovascular Diseases
- Electric and Hybrid Vehicle Technologies
- Surface Roughness and Optical Measurements
- Bone Metabolism and Diseases
- Angiogenesis and VEGF in Cancer
- Hormonal Regulation and Hypertension
- Mechanical and Optical Resonators
- Smart Parking Systems Research
- Cerebrovascular and Carotid Artery Diseases
- ATP Synthase and ATPases Research
- Energy Harvesting in Wireless Networks
- Cell Adhesion Molecules Research
- Ion Transport and Channel Regulation
- Nanowire Synthesis and Applications
- Cancer, Hypoxia, and Metabolism
- Dermatological and COVID-19 studies
- SARS-CoV-2 and COVID-19 Research
- Advanced MEMS and NEMS Technologies
- Microfluidic and Bio-sensing Technologies
- S100 Proteins and Annexins
- Molecular Junctions and Nanostructures
Deyang Stomatological Hospital
2025
Nagoya University
2010-2014
Sungkyunkwan University
2014
Brigham and Women's Hospital
2010-2013
Kyung Hee University
2010-2013
Yanbian University Hospital
2010-2013
Harvard University
2010-2013
Shanghai Jiao Tong University
2013
Yanbian University
2013
Nagoya University Hospital
2012
Background— Exercise stimulates the vascular response in pathological conditions, including ischemia; however, molecular mechanisms by which exercise improves impaired hypoxia-induced factor (HIF)-1α–mediated to hypoxia associated with aging are poorly understood. Here, we report that swimming training (ST) modulates ischemia aged (24-month-old) mice. Methods and Results— Aged wild-type mice (MMP-2 +/+ ) maintained ST (swimming 1 h/d) from day after surgery were randomly assigned 4 groups...
The interactions between the renin-angiotensin system and neovascularization in atherosclerotic plaque development are unclear. We investigated effects of angiotensin II type 1 receptor antagonism pathogenesis atherosclerosis apolipoprotein E-deficient (ApoE(-/-)) mice with a special focus on neovascularization. ApoE(-/-) fed high-fat diet were randomly assigned to 2 groups administered vehicle or olmesartan for 12 weeks. Quantification areas at aortic root thoracic abdominal aorta revealed...
Cathepsin K (CatK) is one of the most potent mammalian collagenases. We showed previously increased expression CatK in human and animal atherosclerotic lesions. Here, we hypothesized that ablation mitigates injury-induced neointimal hyperplasia. Male wild-type (CatK +/+ ) CatK-deficient −/− mice underwent ligation or a combination polyethylene cuff-replacement injuries to right common carotid artery just proximal its bifurcation, they were then processed for morphological biochemical studies...
The mineralocorticoid receptor has been implicated in the pathogenesis of chronic cardiorenal disease. Statins improve renal remodeling and dysfunction patients with proteinuric kidney diseases. We aimed to clarify beneficial effects mechanisms action statins insufficiency.Dahl salt-sensitive rats fed a high-salt diet were treated from 12 20 weeks age vehicle, reduced nicotinamide-adenine dinucleotide phosphate (NADPH) oxidase inhibitor apocynin, synthetic cathepsin E64d, or low high dosage...
Summary 1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation activity of MMP‐2 regulated by intrinsic tissue inhibitor (TIMP‐2). aim present study was to examine whether, conversely, can affect gene protein expression TIMP‐2. 2. In study, we examined mRNA TIMP‐2 cultured smooth muscle cells (SMC) from aortas +/+ −/− mice. We also roles SMC cellular events. 3. Western blotting showed that less conditioned medium...
Long-wavelength InAlGaAs VCSELs with Al2O3 embedded current-confinement structures are reported. Using atomic layer deposition, the current confinement fabricated by depositing on airgap surfaces of undercut apertures, which formed laterally etching active region. 1.57 µm showing an output power over 1 mW and direct modulation characteristics at 4 Gbit/s reported using these apertures.
A deep back chamber micro-electro-mechanical system (MEMS) acoustic sensor with two sacrificial layers based on surface micromachining a GaAs substrate is presented. As it designed to be implemented only the front side of in order satisfy need for simple monolithic integrated process, this has bottom electrode anchors fabricated using first layer formation chamber. Each anchor, rectangular area 50 μm x μm, enables act as stiff plate because make fix onto through patterning layer. The...
Abstract This paper reports a novel micro/nano fabrication method for mass production of low-stressed silicon nitride (SiN) membrane nanopores with the precisely size-controlled 30 nm in diameter using an anisotropic reactive ion etching (ARIE) and nano-imprinting method, while maintaining compatibility CMOS IC processes. Our differs from that Striemer group [1] specific material, Hien [2] protocols. Micromachining protocols facilitate accomplishing nanostructures to be used separation...
In this work, we describe the successful demonstration of continuous wave (CW) operation all monolithic air-gap 1.55 /spl mu/m VCSELs with tunnel junction grown by MOCVD.
All-monolithic InAlGaAs/InP VCSELs over 1.3/spl sim/1.5 /spl mu/m wavebands were successfully demonstrated. A single mode power of sim/1 mW and modulation bandwidth exceeding 2.5 Gbps at room temperature CW operation 80/spl deg/C obtained in both 1.3 1.5 mu/m.
We demonstrate continuous wave operation of MOCVD-grown 1.55 /spl mu/m buried tunnel junction VCSELs at room temperature. This VCSEL structure is prepared by MOCVD twofold epitaxial growth. The threshold current and emission wavelength for a 10 mu/m-diameter device are 3.5 mA 1552 nm, respectively.
Low threshold power vertical-cavity surface-emitting lasers are fabricated by using low loss AlxOy/GaAs mirrors as output couplers. A 5 µm-aperture laser with a CW pump of 1.4 mW at room temperature and 16 operating in mode up to 64°C produced.
The purpose of this paper is to construct a control algorithm for improving the driving efficiency 4-wheel-drive in-wheel electric vehicles. main parts vehicle were modeled and input-output relations signals summarized using MATLAB/Simulink. A performance simulator vehicles was developed based on co-simulation environment with commercial dynamic behavior analysis program called Carsim. Moreover, vehicles, torque distribution algorithm, which distributes front rear wheels, included in...
Objective. The renin-angiotensin-aldosterone system (RAAS) has been implicated in the pathogenesis of chronic cardiorenal diseases. Statins and angiotensin type 1 receptor (AT1R) antagonist improve hypertensive renal remodeling dysfunction patients with proteinuric kidney disease. present study investigated comparative effects a combination statin AT1R monotherapy on injury. Methods Results. Dahl salt-sensitive (DS) rats high-salt diet were randomly assigned to four groups ( n = 10 for each...
Background. Cathepsin K (Cat K), a potent elastinolytic and collagenolytic cysteine protease, is considered likely to participate in the development destabilization of atherosclerotic plaques. In order define role Cat arterial remodeling, we evaluated influence targeted deletion gene K−/−) on vascular remodeling after flow cessation murine carotid arteries. Methods Results. Male K+/+ K−/− mice receiving normal chow underwent ligation or ligation/polyethylene cuff-placement injuries left...
Background : Cysteine protease cathepsins (Cats) have been implicated in the process of neovascularization. However, exact roles individual Cat proteins vessel formation are poorly understood. Methods and Results To study putative role cathepsin K (CatK) ischemia-induced neovascularization, a hindlimb ischemia model was applied to CatK+/+ CatK-/- mice. Serial laser Doppler blood-flow analysis revealed that recovery ischemic/normal ratio young old mice remained impaired throughout follow-up...
Lysosomal protease cathepsin (Cat) overexpressed in atherosclerotic lesions has a strong proteolytic activity. Given that reactive oxygen species (ROS) are also implicated activation atherogenesis, we examined possible role of the ROS-induced system neointima formation and plaque stability. Murine vascular injury-induced was by use carotid artery ligation model, which demonstrated K deficiency impaired cystatin C enhanced it (9-week-old males; n = 18 for each group, P< 0.01). To examine...
A novel structure of 1.55 um bottom-emitting InAlGaAs VCSELs grown by single-step MOCVD has been thermally analyzed in simulation and measurement through active sizes, to be optimized the performances for flip-chip bonded assembly on Si-substrate.
전자선 증착기를 이용하여 <TEX>$1.3{\mu}m$</TEX> 중심 파장의 파브리-페로 에탈론을 <TEX>$Al_{2}O_3$</TEX>와 a-Si 박막 쌍으로 증착하였다. 제작된 에탈론의 투과율 및 반사율 스펙트럼을 측정하여, 공진 파장에서 투과 반치폭이 <TEX>${\sim}12.1\;nm$</TEX>이며 피네세(finesse) 값은 53임을 알았다. <TEX>$Al_{2}O_3$</TEX> 단일박막의 광학 상수는 타원분광기법으로 측정하였다. 측정을 통하여 박막의 굴절률은 각각 실수부 3.120, 허수부 0.002로 이러한 쌍은 파장 표면방출레이저의 출력 반사경으로 사용 가능하다. We have fabricated a Fabry-Perot etalon around <TEX>$1.3\;{\mu}m$</TEX> wavelength utilizing and thin films. A full width at half maximum of...