A5069083249- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Cardiac pacing and defibrillation studies
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Sports Performance and Training
- Cardiovascular Syncope and Autonomic Disorders
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- ECG Monitoring and Analysis
- Hemodynamic Monitoring and Therapy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Muscle metabolism and nutrition
- High Altitude and Hypoxia
- Non-Invasive Vital Sign Monitoring
- Muscle activation and electromyography studies
- Coronary Interventions and Diagnostics
Karolinska Institutet
2015-2024
Karolinska University Hospital
2015-2024
Karolinska Development (Sweden)
2023
Swedish School of Sport and Health Sciences
2005
Policlinico San Matteo Fondazione
2005
Istituti di Ricovero e Cura a Carattere Scientifico
2005
Stockholm University College of Music Education
1998-2000
Stockholm South General Hospital
1988-1998
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist can be challenging to treat. Pharmacologically based rhythm control of AF has not proven superior rate control. Ablation-based was compared with evaluate if clinical outcomes in patients HF could improved. Methods: This a multicenter, open-label trial blinded outcome evaluation using central adjudication committee. Patients high-burden paroxysmal (>4 episodes 6 months) or persistent (duration <3 years) AF,...
The effects of age and gender on heart rate variability as measured by spectral time domain analysis 24 h ECG recordings were evaluated in 101 healthy subjects, 49 men 52 women (20‐69 years age). In the frequency domain, total power, very low‐frequency power high‐frequency negatively correlated to (P < 0.001 for all variables). Total decreased 30% between 20‐29 60‐69 age. SDNN‐index, mean standard deviations normal R‐R intervals 5 min segments a recording, was <0.001)....
To determine whether conditions for O 2 utilization and off-loading from the hemoglobin are different in exercising arms legs, six cross-country skiers participated this study. Femoral subclavian vein blood flow gases were determined during skiing on a treadmill at ∼76% maximal uptake (V̇o max ) V̇o with techniques: diagonal stride (combined arm leg exercise), double poling (predominantly exercise). The percentage of extraction was always higher legs than arms. At exercise (diagonal stride),...
That muscular blood flow may reach 2.5 l kg −1 min in the quadriceps muscle has led to suggestion that vascular conductance must be restrained during whole body exercise avoid hypotension. The main aim of this study was determine maximal arm and leg conductances (VC) exercise, find out if vasodilatory response is combined exercise. Six Swedish elite cross‐country skiers, age (mean ± s.e.m. ) 24 2 years, height 180 cm, weight 74 kg, oxygen uptake 5.1 0.1 participated study. Femoral subclavian...
To study the role of muscle mass and activity on lactate energy kinetics during exercise, whole body limb lactate, glucose, fatty acid fluxes were determined in six elite cross-country skiers roller-skiing for 40 min with diagonal stride (Continuous Arm + Leg) followed by 10 double poling at 72–76% maximal O 2 uptake. A high appearance rate (R a , 184 ± 17 μmol · kg −1 ) but low arterial concentration (∼2.5 mmol/l) observed Continuous Leg despite substantial net release arm ∼2.1 mmol/min,...
<h3>Objective</h3> This study examines the influence of physical activity at different ages and types, on risk developing atrial fibrillation (AF) in a large cohort Swedish men. <h3>Methods</h3> Information about was obtained from 44 410 AF-free men, aged 45–79 years (mean age=60), who had completed self-administered questionnaire baseline 1997. Participants reported retrospectively their time spent leisure-time exercise walking or bicycling throughout lifetime (at 15, 30 50 age, age=60))....
Previous studies have found that regular participation in intense physical activity increases the risk of developing atrial fibrillation (AF) men, but it remains unclear how influences AF women. We aimed to examine whether different types and at ages development women.In population-based Swedish Mammography Cohort, information about was obtained from 36 513 AF-free women (49-83 years old, median age 60 years) who had completed a questionnaire study entry (1997). Participants reported their...
Previous studies have found that endurance sport activity is associated with an increased risk of atrial fibrillation (AF) in men. However, it remains unclear whether sports also influence the AF women. We aimed to examine participation may affect female athletes.We conducted a retrospective matched cohort study top Swedish athletes (n=228) and reference individuals (n=1368) from general population using Total Population Register individually 6:1 ratio athletes. The athlete was created by...
Abstract Background : The recurrence rate of atrial fibrillation (AF) after elective cardioversion is high. Hypothesis study aimed to identify clinical predictors for successful electrical and maintenance sinus rhythm a first in patients with persistent AF without concomitant antiarrhythmic drugs class I III. Methods Consecutive outpatients (n = 166) > 1 month, scheduled cardioversion, were prospectively included the study. A investigation, echocardiographic assay, Holter...
Controversy remains as to whether the exercise stress test (EST) is sufficient for risk evaluation in patients with pre-excitation. This study aims clarify usefulness of EST stratification both asymptomatic and symptomatic presenting
Background and Purpose —We investigated whether, in a randomly selected population of 55-year-old men women, there is relationship between common carotid artery (CCA) diameter intima-media (IM) thickness conventional risk factors for cardiovascular disease such as gender, smoking, elevated blood lipids, high pressure. Methods —CCA IM the distal right left CCAs were measured by high-frequency ultrasound methods. Fifty-seven (73% invited men) 47 women (62% women) participated. Results —In...
Forty‐eight hour Holter monitoring was undertaken of 16 male elite middle‐ and long‐distance runners, age 25±3 years, with peak oxygen uptake 4.83±0.43 1 O 2 /min or 73.0±3.9 ml /kg/min. The athletes had pronounced bradycardia during the night‐time, heart rate calculated from four RR intervals <30 beats/min in five runners. Twelve runners >2 s. Of those, 10 sinus pauses exceeding s, longest being 3.06 Three AV block II, two Mobitz type 1, one both 2. Autonomic function estimated by...
Summary. Arm and leg metabolism were compared by arterial venous catheterization blood flow measurements (by dye dilution techniques) in two groups of subjects performing 30‐min continuous arm or exercise increasing intensity corresponding to approximately 30, 50 80% max oxygen uptake for exercise. The absolute work‐loads 2·5‐3 times higher during Heart rates the same both types r ‐Values 0·97‐1·07 Arterial noradrenaline adrenaline levels became (P< 0·05401). lactate concentration was 50%...
Objectives. Using a patient and gender perspective, this study evaluates the experiences perspectives of referral for paroxysmal supraventricular tachycardia (PSVT), symptoms, Health-Related Quality Life (HRQOL) functional impairment before six months after ablation. Design. This prospective includes 214 (109 women) patients with PSVT who completed questionnaires ablation addressing patterns, duration arrhythmia, socioeconomic status, HRQOL, impairment. Result. Women had longer history...
Abstract Aim We examined the Fick components together with mitochondrial O 2 affinity (p50 mito ) in defining extraction and uptake during exercise large small muscle mass normoxia (NORM) hyperoxia (HYPER). Methods Seven individuals performed incremental tests to exhaustion on a bicycle ergometer (BIKE) 1‐legged knee extension (KE) NORM or HYPER. Leg blood flow VO were determined by thermodilution method. Maximal ADP‐stimulated respiration (OXPHOS) p50 measured ex vivo isolated mitochondria....
AimsRadiofrequency (RF) ablation of the cavotricuspid isthmus (CTI) is an effective treatment for atrial flutter (AFL). However, RF may injure cardiac structures such as atrio-ventricular node or right coronary artery and usually painful. This prospective, randomized study compares cryoablation (Cryo) with regarding efficacy, safety, perceived pain.
Cryoablation is an alternative method to radiofrequency ablation for treatment of atrioventricular nodal re-entrant tachycardia (AVNRT). This study investigates the long-term safety and efficacy cryoablation in AVNRT.We studied 515 consecutive patients (317 women, mean age 50 years, range 13-89 years) undergoing a first AVNRT between 2003 2008. Ablations were performed with 6-mm Freezor Xtra catheter. Six acute failures; 494 out 509 (97%) primarily successfully ablated followed up 7.1 years...
<h3>Objective</h3> To characterise cardiac arrhythmias and autonomic function in 11 elderly men (mean (SD) age 73.2 (2.8) years) with a lifelong history of regular very strenuous exercise. A control group 12 healthy sedentary or moderately physically active (74.5 (2.7) was also studied. <h3>Design</h3> 48 hour ambulatory electrocardiograms were recorded. Cardiac estimated from power spectral analysis heart rate variability. Maximal oxygen uptake during treadmill exercise testing 2.91 (0.52)...