A5031658231- Cardiovascular Function and Risk Factors
- Multiple Myeloma Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Analytical Methods in Pharmaceuticals
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Peptidase Inhibition and Analysis
- Hemodynamic Monitoring and Therapy
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Cancer Treatment and Pharmacology
- Pulmonary Hypertension Research and Treatments
- Aortic Disease and Treatment Approaches
- Heart rate and cardiovascular health
- Coronary Artery Anomalies
- Psychosomatic Disorders and Their Treatments
- Aortic aneurysm repair treatments
- Ultrasound and Hyperthermia Applications
- Cardiac pacing and defibrillation studies
- Cardiovascular Syncope and Autonomic Disorders
University of Turin
2020-2025
Universitat Autònoma de Barcelona
2025
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2021-2024
Vall d'Hebron Institut de Recerca
2024
Candiolo Cancer Institute
2024
Ospedale San Luigi Gonzaga
2024
Fondazione Ricerca Molinette
2021-2023
Azienda Ospedaliero Universitaria San Giovanni Battista
2023
GTx (United States)
2021
The potential relevance of blood flow for describing cardiac function has been known the past 2 decades, but association clinical parameters with complexity fluid motion is still not well understood. Hemodynamic force (HDF) analysis represents a promising approach study within ventricular chambers through exploration intraventricular pressure gradients. Previous experimental studies reported significance invasively measured gradients in patients heart failure. Subsequently, advances...
Abstract Background Cardiac magnetic resonance (CMR) is essential for diagnosing cardiomyopathy, serving as the gold standard assessing heart chamber volumes and tissue characterization. Hemodynamic forces (HDF) analysis, a novel approach using cine CMR images, estimates energy exchange between left ventricular (LV) wall blood. While prior research has focused on peak or mean longitudinal HDF values, this study aims to investigate whether unsupervised clustering of curves can identify...
Abstract Background Dilated cardiomyopathy (DCM) is associated with an increased risk of major adverse cardiovascular events (MACE). However, current stratification methods are imperfect. Left atrial global longitudinal strain (LA GLS) increasingly acknowledged predictive parameter, yet its potential role in DCM not well defined. Purpose This study aims to investigate the prognostic cardiac magnetic resonance (CMR)-derived LA GLS for occurrence MACE patients DCM. Methods A retrospective,...
Background: Ascending aorta (ASC) dilatation (AAD) is a common finding in arterial hypertension, affecting about 15% of hypertensive patients. AAD associated with an increase cardiac and vascular hypertension-related organ damage, but its prognostic role unknown. The aim the study was to evaluate value as predictor cardiovascular events essential Methods: Recruited patients underwent two-dimensional transthoracic echocardiography from 2007 2013 followed-up for until November 2018 by phone...
Graphical Abstract Risk variation of presenting increased left ventricular filling pressure (upper graph) and PCWP (lower graph), according to the proposed scoring system. EF, ejection fraction; DLF, diastolic longitudinal force; LAe, atrial enlargement; ILFP, pressure; NLFP, normal PCWP, postcapillary wedge pressure.
Transcatheter aortic valve implantation (TAVI) is the established first-line treatment for patient with severe stenosis not suitable surgery. Echocardiographic evaluation of hemodynamic forces (HDFs) a growing field, holding potential to early predict improvement in LV function. A prospective observational study was conducted. Transthoracic echocardiography performed before and after TAVI. HDFs were analyzed along traditional left ventricular (LV) function parameters. Twenty-five consecutive...
Cardiovascular adverse events (CVAEs) are linked to Carfilzomib (CFZ) therapy in multiple myeloma (MM); however, no validated protocols on cardiovascular risk assessment available. In this prospective study, the effectiveness of European Myeloma Network protocol (EMN) was investigated, identifying major predictors CVAEs. From January 2015 March 2020, 116 MM patients who had indication for CFZ underwent a baseline evaluation (including blood pressure measurements, echocardiography and...
Background: Carfilzomib improves the prognosis of multiple myeloma (MM) patients but significantly increases cardiovascular toxicity. The timing and effect therapy on left ventricular function is still under investigation. We sought to assess echocardiographic systo-diastolic changes, including global longitudinal strain (GLS), in treated with identify predictors increased risk adverse events (CVAEs) during therapy. Methods: Eighty-eight MM performed a baseline evaluation comprehensive...
Carfilzomib-mediated cardiotoxicity in multiple myeloma (MM) is a well-established adverse effect, however limited data are available on the comparison of cardiovascular complications patients treated with Carfilzomib-dexamethasone (target dose K 56 mg/m2) versus Carfilzomib-lenalidomide-dexamethasone 27 beyond controlled trials. A total 109 were enrolled, 47 (43%) received Kd and 62 (57%) KRd. They then underwent baseline follow-up evaluation including trans-thoracic echocardiography...
Background. Transcatheter edge-to-edge repair (TEER) is a safe and effective treatment in symptomatic patients with mitral regurgitation (MR). We aimed to investigate the short-term impact of TEER on left ventricular (LV) performance identify echocardiographic prognostic indicators. Methods. Seventy-eight severe MR (organic functional etiologies) were included retrospectively. All had baseline echocardi-ography after followed up for primary composite endpoint (heart failure hos-pitalization...
Introduction: Non-ischemic dilated cardiomyopathy (NIDCM) is characterized by a reduced left ventricular (LV) ejection fraction (LVEF, <50%) and high risk for heart failure (HF) death. Echocardiography-derived hemodynamic forces (HDFs) may provide important information on LV mechanics, but their prognostic value unknown. Aim: To explore the features of echocardiography-derived HDFs in NIDCM association with clinical endpoints. Methods: Asymptomatic, non-hospitalized patients free from...
Multiple myeloma (MM) affects a population with high prevalence of cardiovascular (CV) disease. These patients benefit from an accurate CV risk evaluation in order to choose the safest drug regimen. Haemodynamic forces (HDFs) analysis allows for earlier detection myocardial damage compared standard markers; role played by MM HDFs alteration, or without influence hypertension, is yet be studied. Therefore, we aimed identify differences MM, hypertension both versus normotensive non-oncologic...
Background: A hierarchical symptoms-based diagnostic strategy relying on the presence of five main symptoms (chest pain, acute dyspnea, neurological symptoms, headache, visual impairment) was recently proposed to diagnose patients with hypertensive emergency. However, poor scientific evidence is available about role in both diagnosis and management disorders. Methods: Data from 718 presenting emergency department “Città della Salute e Scienza” Hospital Turin systolic blood pressure > 180...
Ascending aorta dilatation is found in 13% of hypertensive patients. Little known about elastic properties ascending such Echo-based transverse aortic strain analysis can describe mechanical but has never been applied to patients with dilatation.To assess by (as β2-stiffness index) and association between cardiovascular damage.A total 100 outpatients underwent transthoracic echocardiography assessment pulse wave velocity (PWV). Strain was performed echocardiographic speckle-tracking...
The prevalence of hypertension mediated organ damage (HMOD) in patients attending the Emergency Department (ED) with symptomatic blood pressure (BP) rise is unknown, and whether HMOD varies between asymptomatic grade 3 unclear.This study aimed to investigate cardiac vascular hypertensive urgencies (HU) outpatients 1-3 hypertension.Patients ED a BP ≥180/110 mmHg were prospectively enrolled (HU group), after exclusion acute damage. assessed 72 h from discharge an office setting. These matched...
Carfilzomib (CFZ) improves the prognosis of multiple myeloma (MM) patients but has shown cardiovascular toxicity. The risk stratification adverse events (CVAEs) now seems well established, while little is known about course and management with a high-cardiovascular-risk profile or experiencing CVAEs during therapy. Therefore, we aimed to describe our experience in decision making support health professionals selecting best strategies prevent treat CVAEs. A total 194 indication CFZ underwent...
Large artery stiffness, assessed by carotid--femoral pulse wave velocity (cfPWV), is a major risk factor for cardiovascular events, commonly used stratification. Currently, the reference device noninvasive cfPWV SphygmoCor but its cost and technically challenging use limit diffusion in clinical practice.To validate new assessment of cfPWV, ATHOS (Arterial sTiffness faitHful tOol aSsessment), designed collaboration with Politecnico di Torino, against method represented SphygmoCor.Ninety...
Abstract Background Paravalvular regurgitation (PVR) after TAVR is a frequent complication, but its direct quantification and grading with conventional echocardiography still limited by several factors. LV remodeling has role in the evaluation of PVR pathophysiology. Hemodynamic forces (HDF) analysis emerged as new tool to evaluate cardiac function addiction ejection fraction (EF) global longitudinal strain (GLS). Aim study: To difference pre– post–TAVR HDF patients preserved EF, using...
Objective: Background: Arterial hypertension (AH) is the main risk factor for cardiovascular events western populations. Blood pressure (BP) usually measured at brachial artery level, but current evidence suggest that central blood (cBP) could have a greater prognostic role. Recent studies showed Systolic BP (cSBP) can be reliably estimated by Direct Central Pressure formula (DCBP = MBP2/DBP) using mean (MBP) and diastolic (DBP) level. Aim: this study seeks to compare cSBP calculated DCBP...
Objective: Blood pressure variability (BPV) is an independent predictor of cardiovascular (CV) events and overall mortality. The potential role BPV in defining CV risk patients undergoing anticancer therapy with a cancer therapy-related toxicity (CTR-CVT) currently unknown. aims this study were: (i) to assess the predictive value indexes for CTR-CVT development corresponding cut-off values; (ii) identify subgroups subjects based on BPV, through clustering analysis. Design method: Patients...
Longitudinal data on reverse cardiac remodeling and outcomes after transcatheter edge-to-edge repair (TEER) are limited.