A5044504067- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Cardiovascular Effects of Exercise
- Radiation Dose and Imaging
- Cardiac Valve Diseases and Treatments
- Ultrasound and Hyperthermia Applications
- Cardiac Structural Anomalies and Repair
- Health Systems, Economic Evaluations, Quality of Life
- Virus-based gene therapy research
- Children's Physical and Motor Development
- Obesity, Physical Activity, Diet
- Parkinson's Disease Mechanisms and Treatments
- Advanced X-ray and CT Imaging
- Physical Activity and Health
- Icing and De-icing Technologies
- Arctic and Antarctic ice dynamics
- Cytomegalovirus and herpesvirus research
- Blood Pressure and Hypertension Studies
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
University of Turin
2018-2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2020-2024
Despite marked advancements in its treatment, breast cancer is still the second leading cause of death women, due to relapses and distal metastases. Breast stem cells (CSCs), are a cellular reservoir for recurrence, metastatic evolution disease progression, making development novel therapeutics that target CSCs, thereby inhibit metastases, an urgent need. We have previously demonstrated cystine-glutamate antiporter xCT (SLC7A11), protein was shown be overexpressed mammary CSCs plays key role...
The Daily Mile™ is an innovative school-based intervention that requires children to run or jog outside for 15 min at a self-selected pace during class time. Today, only one study has investigated the efficacy of Mile on physical fitness, which was conducted with Scottish children. Thus, we aimed evaluate feasibility and effectiveness in Italian primary schools. A total 486 participated 3 months (experimental group), whereas 309 continued their daily school routine (control group). 6-min...
The relationship between epicardial adipose tissue (EAT) and atrial fibrillation (AF) has gained interest in recent years. previous literature on the topic presents great heterogeneity, focusing especially computed tomography imaging. aim of present study is to determine whether an increased volume left (LA) EAT evaluated at routine pre-procedural cardiac magnetic resonance imaging (MRI) relates AF recurrences after catheter ablation. A total 50 patients undergoing cryoballoon ablation MRI...
Abstract Aims Whereas pulmonary vein isolation (PVI) is the universally agreed target in catheter ablation of paroxysmal atrial fibrillation (AF), an ideal set persistent AF remains questioned. Aim this study to conduct a network meta-analysis (NMA) randomized clinical trials (RCTs) comparing different strategies patients. Methods and results Network was performed frequentist framework with constituting competitive arms interest. Primary efficacy endpoint recurrences tachyarrhythmia (AF,...
Transcatheter aortic valve implantation (TAVI) is the established first-line treatment for patient with severe stenosis not suitable surgery. Echocardiographic evaluation of hemodynamic forces (HDFs) a growing field, holding potential to early predict improvement in LV function. A prospective observational study was conducted. Transthoracic echocardiography performed before and after TAVI. HDFs were analyzed along traditional left ventricular (LV) function parameters. Twenty-five consecutive...
Background. Cardiologists are today exposed to a growing dose of ionising radiation in their practice. Radiation awareness and correct management X-ray use the cornerstone comply with principles exposure optimization justification. Methods Results. An investigator-initiated international voluntary-based survey including 28 questions was conducted across 19 European countries. 228 cardiologists participated survey. Invasive cardiology subspecialties were most represented (83.6%). is cause...
Background and objectives: Atrial fibrillation (AF) dementia are growing causes of morbidity mortality, representing relevant medical socioeconomic burdens. In this study, based on data from the Global Burden Disease Injuries Risk Factors Study (GBD) 2019, we focused AF distribution investigated potential correlation between two epidemiological trends. Materials Methods: Crude age-standardized incidence, prevalence, mortality rate, disability-adjusted life years (DALYs) lost, derived GBD...
Bileaflet Mitral Valve Prolapse (bMVP) has been linked to major arrhythmic events and sudden cardiac death (SCD). Consistent predictors in this field are still lacking. Echocardiography is the best tool for analysis of prolapse its impact on ventricular mechanics. The aim study was find new echocardiographic malignant within an MVP population. We evaluated 22 patients with bMVP a transthoracic echocardiogram focused mitral valve anatomy contraction. Six them had that required ICD...
Current guidelines recommend the use of cardiac magnetic resonance imaging (MRI) for management atrial fibrillation (AF). However, widespread MRI in clinical practice is difficult to achieve. The aim present study assess whether can be adopted identify ablation-induced fibrosis, and its relationship with AF recurrences. Fifty patients undergoing cryoballoon ablation were prospectively enrolled. Cardiac was performed before 30 days after index ablation. Commercially available software a...
The objective of this study is to describe a suitable model atrial fibrillation cryoablation thermodynamic properties. Three different thermal loads were applied cylindrical copper element simulating the cryoprobe, thermally coupled with Peltier stack producing freezing effect, and in contact bovine liver sample. Thermal events occurring inside samples measured using mirror image technique. Heat subtracted flux during ice formation minimum temperature at probe–tissue interface were,...
Aims Radiation use in medicine has significantly increased over the last decade, and cardiologists are among specialists most responsible for X-ray exposure. The present study investigates a broad range of aspects, from specific European Union directives to general practical principles, related radiation management national cohort cardiologists. Methods results A voluntary 31-question survey was run on Italian Arrhythmology Pacing Society (AIAC) website. From June 2019 January 2020, 125...
Aim To report the Italian data deriving from European Society of Cardiology-EURObservational Research Program atrial fibrillation ablation long-term registry. Methods and results Ten centers enrolled up to 50 consecutive patients undergoing ablation. Of 318 included, 5 (1.6%) did not undergo catheter ablation, 1 had partially done 62 were lost at 1-year follow-up. Women less represented (23.6%) median age was 60.0 years. A total 195 (62.3%) suffered paroxysmal fibrillation, whereas only 9...
Abstract Aim of the present study is to analyze thermal events occurring during cryoablation. Different bovine liver samples underwent freezing cycles at different cooling rate (from 0.0075 25 K/min). Ice onset temperature and specific latent heat capacity ice formation process were measured according differential scanning calorimetry signals. A computational model cryoablation was compiled using Neumann’s analytical solution. Latent (#1 = 139.8 ± 7.4 J/g, #2 147.8 7.9 #3 159.0 4.1 J/g) all...
Abstract Background Despite the high prevalence of atrial high-rate episodes (AHRE) detected by cardiac implantable electronic devices (CIED), clinical guidelines and consensus documents have failed to agree on a universal AHRE definition. Clear evidence best management strategy is lacking. Purpose The present diagnostic test accuracy meta-analysis aiming derive from available literature optimal threshold predict thromboembolic events. Methods PubMed/MEDLINE EMBASE databases were screened...
The relationship between epicardial adipose tissue (EAT) and atrial fibrillation (AF) has gained interest in recent years. Previous literature on the topic presents great heterogeneity, focusing especially computed tomog-raphy imaging. Aim of present study is to determine whether an increased volume left (LA) EAT evaluated at routine pre-procedural cardiac magnetic resonance imaging (MRI) relates AF recurrences after catheter ablation. 50 patients undergoing cryoballoon ablation MRI allowing...