A5042986591- Alzheimer's disease research and treatments
- Thin-Film Transistor Technologies
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Mitochondrial Function and Pathology
- Silicon Nanostructures and Photoluminescence
- High-Energy Particle Collisions Research
- Cholinesterase and Neurodegenerative Diseases
- Silicon and Solar Cell Technologies
- DNA Repair Mechanisms
- Plasma Diagnostics and Applications
- Tryptophan and brain disorders
- Diamond and Carbon-based Materials Research
- Signaling Pathways in Disease
- Nuclear physics research studies
- Carcinogens and Genotoxicity Assessment
- Retinoids in leukemia and cellular processes
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Metabolomics and Mass Spectrometry Studies
- Coenzyme Q10 studies and effects
- Biochemical Acid Research Studies
- Vitamin C and Antioxidants Research
- Semiconductor materials and devices
- Genetics, Aging, and Longevity in Model Organisms
Universitat de València
2014-2024
Hospital General Universitario de Alicante Doctor Balmis
2024
INCLIVA Health Research Institute
2019-2024
Centro de Investigación Biomédica en Red
2021-2024
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2021-2023
Brf (Brazil)
2021
University of Alicante
2003
Ludwig-Maximilians-Universität München
2003
University of Bergen
2003
Charles University
2003
ou non, émanant des établissements d'enseignement et de recherche français étrangers, laboratoires publics privés.
Oxidative stress is a hallmark of Alzheimer’s disease (AD). We propose that rather than causing damage because the action free radicals, oxidative deranges signaling pathways leading to tau hyperphosphorylation, disease. Indeed, incubation neurons in culture with 5 µM beta-amyloid peptide (Aβ) causes an activation p38 MAPK (p38) leads hyperphosphorylation. Inhibition prevents Aβ-induced phosphorylation. effects are prevented when co-incubated trolox (the water-soluble analog vitamin E). have...
Obstetrical & Gynecological Survey: September 2003 - Volume 58 Issue 9 p 576-577 doi: 10.1097/01.OGX.0000083707.66356.1C
The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up to resolve the problems associated with measurement of background levels oxidative damage (in particular 8-oxo-7,8-dihydroguanine, or 8-oxoGua) in human cells. A tendency for oxidation occur during sample preparation prior chromatography has been recognized as source a very substantial artefact. To assess success attempts eliminate artefact, ESCODD distributed its members standard samples pig liver and HeLa cells...
We present a study on the development and evaluation of fully automated radio-frequency glow discharge system devoted to deposition amorphous thin film semiconductors insulators. The following aspects were carefully addressed in design reactor: (1) cross contamination by dopants unstable gases, (2) capability operation, (3) precise control parameters, particularly substrate temperature, (4) high chemical purity. new reactor, named ARCAM, is multiplasma-monochamber consisting three separated...
There is controversy as to whether vitamin E beneficial in Alzheimer's disease (AD). In this study, we tested if prevents oxidative stress and loss of cognition AD. Fifty-seven AD patients were recruited divided two groups: placebo or treated with 800 IU per day for six months. Of these 57 patients, only 33 finished the study. We measured blood oxidized glutathione (GSSG) used following cognitive tests: Mini-Mental State Examination, Blessed-Dementia Scale, Clock Drawing Test. those E, found...
Amyloid-β peptide (Aβ) toxicity and tau hyperphosphorylation are hallmarks of Alzheimer's disease (AD). How their molecular relationships may affect the etiology, progression, severity disease, however, has not been elucidated. We now report that incubation fetal rat cortical neurons with Aβ upregulates expression Regulator Calcineurin gene RCAN1, this is mediated by Aβ-induced oxidative stress. (PPP3CA) a serine-threonine phosphatase dephosphorylates tau. RCAN1 proteins inhibit activity...
Obesity is known to induce leptin and insulin resistance. Leptin a peptide hormone synthesized in adipose tissue that mainly regulates food intake. It has been shown stimulates the production of when adipocytes are exposed glucose encourage satiety; while leptin, via negative feedback, decreases release enhances sensitivity it, leading uptake for energy utilization or storage. Therefore, resistance closely related middle age also Alzheimer's disease (AD). In recent years, relation between...
α-Tocopheryl succinate (α-TOS) is a semisynthetic vitamin E analogue with high pro-apoptotic and anti-neoplastic activity [Weber, T et al. (2002) Clin. Cancer Res. 8, 863−869]. Previous studies suggested that it acts through destabilization of subcellular organelles, including mitochondria, but compelling evidence missing. Cells treated α-TOS showed altered mitochondrial structure, generation free radicals, activation the sphingomyelin cycle, relocalization cytochrome c Smac/Diablo, multiple...
After having distinguished five successive steps in the temporal evolution of a powder-forming SiH4 radiofrequency glow discharge, we examine initial mechanism by which silicon clusters start growing up to point where they suddenly aggregate into multiply charged particles and modify discharge regime. This 'induction' period can be much longer than diffusion time positive ions neutral radicals, implies that cluster growth involves negative (anions). We provide review basic data concerning...