A5033569421- Gastrointestinal Tumor Research and Treatment
- Cervical Cancer and HPV Research
- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Breast Lesions and Carcinomas
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Endometrial and Cervical Cancer Treatments
- Neurofibromatosis and Schwannoma Cases
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Cell Adhesion Molecules Research
- Colorectal and Anal Carcinomas
- Iron Metabolism and Disorders
- Inflammatory Bowel Disease
- Sarcoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Nonmelanoma Skin Cancer Studies
- Cancer Treatment and Pharmacology
Champalimaud Foundation
2018-2025
Universidade Federal do Rio Grande do Norte
2025
Hospital Garcia de Orta
2013-2023
Instituto Português de Oncologia de Coimbra Francisco Gentil
2023
Promundo
2022
Instituto de Saúde
2022
Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde
2022
University of Cagliari
2022
Hospital Universitario La Paz
2022
Vall d'Hebron Hospital Universitari
2022
Abstract Despite promising preclinical results, average response rates to anti-VEGF therapies, such as bevacizumab, are reduced for most cancers, while incurring in remarkable costs and side effects. Currently, there no biomarkers available select patients that can benefit from this therapy. Depending on the individual tumor, therapies either block or promote metastasis. In context, an assay able predict responses prior treatment, including impact metastasis would prove of great value guide...
Germinal mutations in the base excision repair (BER) gene MUTYH (MYH) have recently been described association with predisposition to multiple colorectal adenomas and cancer. In contrast classic dominant condition of familial adenomatous polyposis (FAP) due germinal APC gene, MYH is an autosomal recessive disease. The identification individuals affected by brings new important implications for diagnostic, screening, genetic counseling, follow up therapeutic options these patients. this...
Invasive lobular breast carcinoma (ILC) is the second most common (BC) subtype and mainly driven by loss of E-cadherin expression. Correct classification BC as ILC important for patient treatment. This study assessed degree agreement among pathologists diagnosis ILC. Two sets hormone receptor (HR)-positive/HER2-negative BCs were independently reviewed participating pathologists. In set A (61 cases), participants provided with hematoxylin/eosin (HE)-stained sections. B (62 HE-stained sections...
Invasive lobular carcinoma (ILC) represents the second most common subtype of breast cancer (BC), accounting for up to 15% all invasive BC. Loss cell adhesion due functional inactivation E-cadherin is hallmark ILC. Although current world health organization (WHO) classification diagnosing ILC requires recognition dispersed or linear non-cohesive growth pattern, it not mandatory demonstrate loss by immunohistochemistry (IHC). Recent results central pathology review two large randomized...
Chemotherapy remains the mainstay in most high-risk breast cancer (BC) settings, with several equivalent options of treatment. However, efficacy each treatment varies between patients and there is currently no test to determine which option will be effective for individual patient. Here, we developed a fast in-vivo BC therapy screening: zebrafish patient-derived-xenograft model (zAvatars), where results can obtained just 10 days. To predictive value zAvatars performed preclinical study, were...
Human epidermal growth factor receptor 2 (HER2) dysregulation is associated with tumorigenesis in gastric/gastroesophageal junction cancer; however, the number of patients HER2-positive disease unclear, possibly due to differing scoring criteria/assays. Data are also lacking for early disease. We aimed assess HER2-positivity rate using approved testing criteria a large, real-life multinational population. was defined as an immunohistochemistry staining score 3+, or 2+ and HER2 amplification...
Recent studies have demonstrated that refluxed duodenal contents cause esophageal carcinoma in rats without exposure to carcinogens. The histopathological spectrum of these carcinomas includes squamous-cell carcinoma, adenocarcinoma and adenosquamous carcinoma. Pure adenocarcinomas are thought arise areas columnar metaplasia adjacent the anastomosis, similar Barrett's esophagus humans. In contrast, histogenesis is unclear. purpose here was investigate pathogenesis a time-course experiment...
Abnormalities of the tumour suppressor gene p53 have been shown in approximately 60% advanced gastric adenocarcinomas and it has suggested that immunohistochemical finding increased expression is a prognostic marker cancer. No studies early (T1) tumours reported. Over protein 95 carcinomas adjacent mucosa was investigated using immunohistochemistry with antibody CM1. Thirty five per cent were positive. The frequency positivity tubular histological type (46%) significantly higher than signet...
Abstract Invasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E‐cadherin loss. Focal activation of P‐cadherin expression in tumor cells that are deficient for occurs subset ILCs. Switching from an to proficient status (EPS) partially restores cell–cell adhesion leading the formation cohesive tubular elements. It unknown what conditions control EPS. Here, we report on EPS ILC metastases large bowel. We reviewed endoscopic colon biopsies...
Recent studies have demonstrated that refluxed duodenal contents cause esophageal carcinoma in rats without exposure to carcinogens. The histopathological spectrum of these carcinomas includes squamous-cell carcinoma, adenocarcinoma and adenosquamous carcinoma. Pure adenocarcinomas are thought arise areas columnar metaplasia adjacent the anastomosis, similar Barrett's esophagus humans. In contrast, histogenesis is unclear. purpose here was investigate pathogenesis a time-course experiment...
Adenocarcinomas of the gastro-esophageal junction (GEJ) and those arising in Barrett's esophagus (BE) are increasing West have a poorer prognosis than distal stomach cancers. This has been attributed mainly to anatomical location, but biological factors such as growth-regulatory molecules implicated. We investigated expression one these factors, TGF alpha, its precursor prepro alpha 82 adenocarcinomas GEJ (32 resected specimens 50 biopsies) well 48 BE biopsies without tumor, by...
We describe a method of immunocytochemical assessment estrogen receptor (ER) status on alcohol-fixed smears obtained by fine-needle aspiration (FNA) from breast cancer patients, using commercially available rabbit monoclonal antibody anti-ER (SP1) without any antigen retrieval. A series 40 aspirates were analyzed and the results ER compared with respective formalin-fixed tissue same procedure classical mouse 6F11 (anti-ER) retrieval paraffin sections. Twenty-four out cases examined positive...
Abstract Barrett's oesophagus has a well‐recognized association with oesophageal adenocarcinoma, phenotypic progression through dysplasia to malignancy. The nuclear phosphoprotein p53 is putative tumour suppressor mutations resulting in both loss of negative growth regulatory function and possible gain oncogene function. Many mutant forms have prolonged half‐life are demonstrable immunohistochemical techniques. We examined 62 endoscopic biopsies 36 resections for overexpression using the...
Abstract Purpose: Cetuximab is an EGFR-targeted therapy approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC). However, about 60% these patients show innate resistance to cetuximab. To increase cetuximab efficacy, it crucial successfully identify responder patients, as well develop new therapeutic approaches overcome resistance. Experimental Design: We evaluated value EGFR effector phospholipase C gamma 1 (PLCγ1) in predicting responses, by analyzing...
<h3>Background</h3> Alport syndrome (AS), a hereditary type IV collagen nephropathy, is major cause of end-stage renal disease in young people. About 85% the cases are X-linked (ATS), due to mutations <i>COL4A5</i> gene. Rarely, families have contiguous gene deletion comprising at least exon 1 and first exons <i>COL4A6</i>, associated with development diffuse leiomyomatosis (ATS-DL). We report three novel deletions identified AS, one which challenges current concepts on genotype-phenotype...
IntroductionThis study aimed to analyse cervical lymphocytic populations in HIV+ and HIV− patients correlate different lesions with HIV viral load presence of high-risk HPV types.Material methodsA total 132 histological specimens from 40 72 were evaluated for CD4+ CD8+ T cell distribution, types, peripheral blood CD4+/CD8+ ratio.ResultsHigh-grade squamous intraepithelial (HSIL) carcinoma (SCC) had lower scores compared patients. In all lesion groups, presented higher epithelial stromal...
DNA ploidy of 100 early gastric carcinomas (T1) was analysed by flow cytometry on archival material from five European centres and correlated to morphological features clinical behaviour. Tumours were classified according the macroscopic appearance, histological type, growth pattern. Aneuploidy observed in 39% tumours. more frequent submucosal than mucosal tumours (p = 0.04), raised flat or ulcerated lesions 0.001), intestinal diffuse types 0.016). The presence lymph node metastasis 10 cases...