A5102956538- Breast Lesions and Carcinomas
- Cancer and Skin Lesions
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Barrier Structure and Function Studies
- Cancer Cells and Metastasis
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- DNA Repair Mechanisms
- Breast Implant and Reconstruction
Semmelweis University
2011-2025
Invasive lobular breast carcinoma (ILC) is the second most common (BC) subtype and mainly driven by loss of E-cadherin expression. Correct classification BC as ILC important for patient treatment. This study assessed degree agreement among pathologists diagnosis ILC. Two sets hormone receptor (HR)-positive/HER2-negative BCs were independently reviewed participating pathologists. In set A (61 cases), participants provided with hematoxylin/eosin (HE)-stained sections. B (62 HE-stained sections...
Invasive lobular carcinoma (ILC) has distinct morphology and association with loss of E-cadherin function. It special clinical imaging features, its proper recognition is important. Following a recent proposal, we tested the value routine use immunohistochemistry (IHC) in recognizing ILC.Five pathologists experience breast pathology from four Hungarian institutions histotyped 1001 cancers diagnostic core biopsies or excision specimens randomly assigned to haematoxylin eosin (HE) diagnosis...
Triple-negative breast cancer (TNBC) is a subtype of with poor prognosis and limited treatment options. This study evaluates the prognostic value stromal markers in TNBC, focusing on tumor–stroma ratio (TSR) overall stroma (OSR) whole slide images (WSI), as well expression type-I collagen, type-III fibrillin-1 tissue microarrays (TMAs), using both visual assessment digital image analysis (DIA). A total 101 female TNBC patients, primarily treated surgery between 2005 2016, were included. We...
A limited number of studies have focused on the mutational landscape breast cancer in different ethnic populations within Europe and compared data with other groups databases. We performed whole-genome sequencing 63 samples from 29 Hungarian patients. validated a subset identified variants at DNA level using Illumina TruSight Oncology (TSO) 500 assay. Canonical breast-cancer-associated genes pathogenic germline mutations were CHEK2 ATM. Nearly all observed as frequent cohort independent...
Invasive micropapillary carcinoma of the breast is characterized by clusters cells presenting with inverted polarity. Although apico-basal polarity a fundamental property epithelium, biological alterations leading to inside-out pattern observed in invasive (IMPC) remain mostly unknown. The regulation tight junctions formation and maintenance acknowledged. By using immunohistochemistry, we have analysed claudin-1, -3, -4, -7 junction proteins expression their prognostic value on IMPCs...