A5001782884- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging and Pathology Studies
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Neonatal Respiratory Health Research
- Lung Cancer Diagnosis and Treatment
- Coenzyme Q10 studies and effects
- Mitochondrial Function and Pathology
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Microtubule and mitosis dynamics
- Glycosylation and Glycoproteins Research
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Renal and related cancers
- RNA modifications and cancer
- Microbial Metabolism and Applications
- Occupational and environmental lung diseases
- Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Ion Transport and Channel Regulation
- Caveolin-1 and cellular processes
Hospital Universitario Virgen del Rocío
2013-2023
Universidad de Sevilla
2011-2016
Instituto de Biomedicina de Sevilla
2013-2016
Consejo Superior de Investigaciones Científicas
2013
Centro de Investigaciones Científicas Isla de la Cartuja
2013
Anthrologica
2011
Coenzyme Q10 (CoQ) is a small lipophilic molecule critical for the transport of electrons from complexes I and II to complex III in mitochondrial respiratory chain. CoQ deficiency rare human genetic condition that has been associated with variety clinical phenotypes. With aim elucidating how affects an organism, we have investigated pathophysiologic processes present within fibroblasts derived 4 patients deficiency. Assays cultured revealed decreased activities II+III, III, IV, reduced...
Abstract Introduction Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress may role in the pathophysiology of fibromyalgia. However, it still not clear whether cause or effect abnormalities documented Furthermore, mitochondria redox imbalance reported fibromyalgia also controversial. We undertook this study to investigate mitochondrial dysfunction, stress, and mitophagy Methods studied 20 patients (2 male,...
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disease most usually caused by point mutations in tRNA genes encoded mtDNA. Here, we report on how this mutation affects function primary fibroblast cultures established from 2 patients with MELAS who harbored the A3243G mutation. Both respiratory chain enzyme activities coenzyme Q(10) (CoQ) levels were significantly decreased fibroblasts. A similar decrease membrane potential was found...
Summary Background Gluten‐free diet (GFD) is the only treatment for patients with coeliac disease (CD) and its compliance should be monitored to avoid cumulative damage. Aims To analyse gluten exposures of on GFD at least 24 months using different monitoring tools impact duodenal histology 12‐month follow‐up evaluate interval determination urinary immunogenic peptides (u‐GIP) adherence. Methods Ninety‐four CD a were prospectively included. Symptoms, serology, CDAT questionnaire, u‐GIP (three...
The paired box transcription factor Pax8 is critical for development of the eye, thyroid gland as well urinary and reproductive organs. In adult, overexpression associated with kidney, ovarian tumors has emerged a specific marker these cancers. Recently, expression was also reported in human pancreatic islets neuroendocrine tumors, identifying novel member Pax family expressed pancreas. Herein, we sought to provide comprehensive analysis during pancreogenesis adult islets....
Human epidermal growth factor receptor 2 (HER2) dysregulation is associated with tumorigenesis in gastric/gastroesophageal junction cancer; however, the number of patients HER2-positive disease unclear, possibly due to differing scoring criteria/assays. Data are also lacking for early disease. We aimed assess HER2-positivity rate using approved testing criteria a large, real-life multinational population. was defined as an immunohistochemistry staining score 3+, or 2+ and HER2 amplification...
To elucidate the role of epithelial-mesenchymal transition markers in gastroenteropancreatic neuroendocrine tumors (GEP NETs) and potential usefulness their clinical management. One hundred ten GEP NET paraffin-embedded samples were immunohistochemically analyzed for E-cadherin, N-cadherin, β-catenin, vimentin, Snail1, Snail2, Twist, Foxc2 protein expression. The 5-year survival rate was reduced those patients showing high Snail1 levels, a cytoplasmic E-cadherin pattern, N-cadherin...
Aquaporin-1 (AQP1) is the main water channel responsible for transport through many epithelia and endothelia. The latest evidence pointed toward an important role of this protein also in gas permeation, angiogenesis, cell proliferation migration. In present work we studied expression AQP1 by immunohistochemical staining 92 lung biopsies from patients diagnosed with a pleuro-pulmonary tumor (71 21 pleural neoplasms). was analyzed comparing results among different histological patterns against...
Odontogenic fibromyxomas are benign odontogenic tumors of mesenchymal origin rare presentation in the oral cavity, which exhibit locally aggressive behavior and prone to local recurrence.The controversy has mainly been on therapeutic management with recommendations varying, depending clinical cases, from simple curettage lesion segmental bone resection.�e present a case report describing reconstruction an os� �e osseous defect maxilla restoration dental implants 32 year old female patient...
Abstract Background Detection of epidermal growth factor receptor ( EGFR) mutations in exons 18–21 is recommended all patients with advanced Non-small-cell lung carcinoma due to the demonstrated efficiency standard therapy tyrosine kinase inhibitors EGFR -mutated patients. Therefore, choosing a suitable technique test mutational status crucial warrant valid result short turnaround time using lowest possible amount tissue material. The Idylla™ Mutation Test simple, fast and reliable method...
The genomic region 17q21 is frequently associated with microsatellite instability and LOH in cancer, including gastric colorectal carcinomas. This contains several putative tumor suppressor genes, Brca1, NM23, prohibitin, spinophilin (Spn, PPP1R9B, neurabin II). scaffold protein Spn one of the regulatory subunits phosphatase-1 (PP1) that targets PP1 to distinct subcellular locations couples its target. Thus, may alter cell-cycle progression via regulation phosphorylation status...
Background Conflicting data exist on the role of pulmonary dendritic cells (DCs) and their maturation in patients with chronic obstructive disease (COPD). Herein, we investigated whether severity smoking status could affect distribution DCs lung tissues undergoing elective pneumectomy or lobectomy for suspected primary cancer. Materials Methods A total 75 consecutive were included. Spirometry testing was used to identify COPD. Lung parenchyma sections anatomically distant from lesion...
Activation of the epithelial-mesenchymal transition process (EMT) by which alveolar cells in human lung tissue undergo differentiation giving rise to a mesenchymal phenotype (fibroblast/miofibroblasts) has been well recognized as key element origin idiopathic pulmonary fibrosis (IPF). Here we analyzed expression AQP1 biopsies patients diagnosed with IPF, and compared it derived from diverse pneumonies, such hypersensitivity pneumonitis, sarcoidosis or normal lungs. Immunostaining for showed...
Aquaporins AQP1 and AQP5 are highly expressed in the lung. Recent studies have shown that expression of these proteins may be mechanistically involved airway inflammation pathogenesis chronic obstructive pulmonary disease (COPD). The aim this study was to investigate bronchial tissue lung parenchyma patients with COPD COPD-resistant smokers.Using a case-control design, we selected group 15 subjects resistant smokers (smokers without COPD) as control, all whom were undergoing resection...
Fibrosing mediastinitis (FM), also called sclerosing or mediastinal fibrosis, is a rare disease characterized by excessive fibrotic reaction in the mediastinum and may compromise airway, great vessels other structures, with morbidity directly related to location extent of fibrosis. The cause not always known but often result granulomatous disease, most histoplasmosis. We report 43-year-old woman history tuberculosis infection 23 years ago. She attended pulmonology clinic for cough dyspnea....
Canonical prefoldin is a protein cochaperone composed of six different subunits (PFDN1 to 6). PFDN1 overexpression promotes epithelial-mesenchymal transition (EMT) and increases the growth xenograft lung cancer (LC) cell lines. We investigated whether this putative involvement canonical PFDN in LC translates into clinic. First, mRNA expression 518 non-small (NSCLC) cases from The Cancer Genome Atlas (TCGA) database was evaluated. Patients with had lower overall survival (OS; 45 vs. 86...
3% of human cancers are renal cell carcinomas (RCC). The most common chromosome abnormality found in this tumor is loss heterozygosity (LOH) on the short arm 3, which suggests that there must be one or more suppressor genes between 3p14 and 3p21 near VHL gene play a relevant role cancer development. DNA from normal tissue 40 patients at various stages RCC was analyzed for LOH three microsatellites mapped to 3p (3p14.1-14.3; 3p21.2-21.3 3p25) by polymerase chain reaction). 42.5% tumors...