A5054580999- Oral microbiology and periodontitis research
- Health and Medical Education
- Oral and gingival health research
- Dental Health and Care Utilization
- Oral Health Pathology and Treatment
- Aging, Health, and Disability
- Dental Implant Techniques and Outcomes
- Dental Radiography and Imaging
- Periodontal Regeneration and Treatments
- Inflammasome and immune disorders
- Oral and Maxillofacial Pathology
- Ethics and bioethics in healthcare
- Coenzyme Q10 studies and effects
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Salivary Gland Disorders and Functions
- Salivary Gland Tumors Diagnosis and Treatment
- Higher Education Teaching and Evaluation
- Autophagy in Disease and Therapy
- Streptococcal Infections and Treatments
- Fatty Acid Research and Health
- Dental Research and COVID-19
- Endodontics and Root Canal Treatments
- Dental Education, Practice, Research
- Advanced Glycation End Products research
- Orthopaedic implants and arthroplasty
Universidad de Sevilla
2015-2024
University of Glasgow
2021
Quantum Pharmaceutical (United Kingdom)
2020
ORCID
2020
Instituto de Biomedicina de Sevilla
2015
Universidad de Granada
2009
University College London
2009
Marche Polytechnic University
2007-2009
University of London
2007
Aurora Periodontics and Implant Dentistry
2001
Abstract While NLRP3‐inflammasome has been implicated in cardiovascular diseases, its role physiological cardiac aging is largely unknown. During aging, many alterations occur the organism, which are associated with progressive impairment of metabolic pathways related to insulin resistance, autophagy dysfunction, and inflammation. Here, we investigated molecular mechanisms through NLRP3 inhibition may attenuate aging. Ablation protected mice from age‐related increased sensitivity, reduced...
Inflammation is a hallmark of aging and negatively affecting female fertility. In this study, we evaluate the role NLRP3 inflammasome in ovarian Age-dependent increased expression ovary was observed WT mice during reproductive aging. High NLRP3, caspase-1, IL-1β also granulosa cells from patients with insufficiency. Ablation improved survival pregnancy rates anti-Müllerian hormone levels autophagy ovaries. Deficiency reduced serum FSH estradiol levels. Consistent these results,...
Abstract Introduction Fibromyalgia is a chronic pain syndrome with unknown etiology. Recent studies have shown some evidence demonstrating that oxidative stress may role in the pathophysiology of fibromyalgia. However, it still not clear whether cause or effect abnormalities documented Furthermore, mitochondria redox imbalance reported fibromyalgia also controversial. We undertook this study to investigate mitochondrial dysfunction, stress, and mitophagy Methods studied 20 patients (2 male,...
Abstract Background Periodontitis, the most prevalent chronic inflammatory disease, has been related to cardiovascular diseases. Autophagy provides a mechanism for turnover of cellular organelles and proteins through lysosome-dependent degradation pathway. The aim this research was study role autophagy in peripheral blood mononuclear cells from patients with periodontitis gingival fibroblasts treated lipopolysaccharide Porphyromonas gingivalis . Autophagy-dependent mechanisms have proposed...
Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic inflammatory diseases. In this study, we investigated the role of AMPK/NLRP3 axis molecular mechanism underlying pain perception.Impairment AMPK induced by compound C or sunitinib, two inhibitors, provoked hyperalgesia mice (p<0.001) marked NLRP3 increased serum levels interleukin-1β...
Abstract Aim To assess the presence of periodontal and opportunistic organisms in patients with peri‐implantitis. Material methods Thirty‐three partially edentulous subjects (22 women, 11 men), aged 32–90 years, who had one or more implants peri‐implantitis were included. Peri‐implantitis was defined as: (i) bleeding on probing and/or suppuration (ii) radiographic images showed marginal bone loss >1.8 mm after 1 year function. Criteria for inclusion were: having at least implant diagnosed...
Olive milling produces olive oil and different by-products, all of them very rich in bioactive compounds like the phenolic alcohol hydroxytyrosol. The aim present study was to investigate effects an fruit extract 20% hydroxytyrosol on molecular mechanisms associated with Alzheimer disease features Aβ- tau- induced toxicity, as well oxidative stress Caenorhabditis elegans. Moreover, characterization extracts, regarding profile content phenolics, total antioxidant ability, investigated....
Background: It has been shown that tobacco is a significant risk factor for periodontal disease; however, there have few studies on young populations where problems of general health can be discounted. The purpose this study was to examine the influence consumption condition young, healthy population. Methods: population consisted 304 Caucasian males (average age 19.38 ± 0.72 years) entering Armed Forces. All subjects completed self‐administered questionnaire age, oral hygiene habits,...
This study was designed to compare the efficacy in supragingival plaque removal of normal toothbrushing practices and a particular technique, modified Bass method.The research consisted two identical experiments with methods: technique. Forty-six secondary, non-dental students (10 males 36 females) ages ranging from 18 30 years were selected. Dental assessed according Turesky modification Quigley-Hein Index. Subjects requested not brush their teeth 48 h prior baseline record index....
To investigate the prevalence, gender influence, and relationships between burnout, depression suicidal ideation within last year among second, fourth fifth-year dental students.A cross-sectional study was carried out in 212 students enrolled fifth years at School of Dentistry Seville using Maslach Burnout Inventory-Student Survey MBI-Human Services Survey, "Patient Health Questionnaire-2", "Questions about Suicidal Ideation Attempted Suicide".The response rate 80%. prevalence higher second...
Resonance frequency analysis (RFA) allows assess implant stability by measuring oscillation on the bone. RFA is an objective and non-invasive method for measurement, although scarce evidence has been provided so far its reliability.Assess Osstell ISQ system's reliability (i.e., measurement reproducibility repeatability) means of intraclass correlation coefficient (ICC) as statistical method.Two registers were completed 85 implants 23 patients. Six measurements each two different SmartPegs...
Aims: Fibromyalgia (FM) is a prevalent chronic pain syndrome characterized by generalized hyperalgesia associated with wide spectrum of symptoms such as fatigue and joint stiffness. Diagnosis FM difficult due to the lack reliable diagnostic biomarkers, while treatment largely inadequate. We have investigated role coenzyme Q10 (CoQ10) deficiency mitochondrial dysfunction in inflammasome activation blood cells from patients, vitro vivo CoQ10 models. Results: Mitochondrial was accompanied...
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Its pathophysiological mechanisms are difficult identify and current drug therapies demonstrate limited effectiveness. Both mitochondrial dysfunction coenzyme Q10 (CoQ10) deficiency have been implicated in FM pathophysiology. We investigated effect CoQ10 supplementation. carried out randomized, double-blind, placebo-controlled trial evaluate clinical gene expression effects forty days...