A5069913209- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Peroxisome Proliferator-Activated Receptors
- Nitric Oxide and Endothelin Effects
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Melanoma and MAPK Pathways
- Biochemical and Molecular Research
- Synthesis and biological activity
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Drug-Induced Hepatotoxicity and Protection
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Glutathione Transferases and Polymorphisms
Instituto de Biomedicina de Sevilla
2015-2024
Universidad de Sevilla
2015-2024
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2020-2024
Hospital Universitario Virgen del Rocío
2015-2023
Instituto de Salud Carlos III
2020-2022
Inflammation is a hallmark of aging and negatively affecting female fertility. In this study, we evaluate the role NLRP3 inflammasome in ovarian Age-dependent increased expression ovary was observed WT mice during reproductive aging. High NLRP3, caspase-1, IL-1β also granulosa cells from patients with insufficiency. Ablation improved survival pregnancy rates anti-Müllerian hormone levels autophagy ovaries. Deficiency reduced serum FSH estradiol levels. Consistent these results,...
Abstract Sorafenib and Regorafenib are the recommended first- second-line therapies in patients with advanced hepatocellular carcinoma (HCC). Lenvatinib Cabozantinib have shown non-inferior antitumoral activities compared corresponding therapies. The clinical trials established doses for each treatment that lead different blood concentrations (10 µM), (1 (0.1 µM). However, very low response rates observed attributed to intrinsic resistances or upregulation of survival signaling. aim study...
Sorafenib is the unique accepted molecular targeted drug for treatment of patients in advanced stage hepatocellular carcinoma. The current study evaluated cell signaling regulation endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK), Akt, and 5'AMP-activated protein (AMPK) leading to autophagy apoptosis induced by sorafenib. early (3-12 hr) ER stress characterized an increase
Circulating Tumor Cells (CTCs) are considered a prognostic marker in pancreatic cancer. In this study we present new approach for counting CTCs and CTC clusters patients with cancer using the IsofluxTM System Hough transform algorithm (Hough-IsofluxTM). The Hough-IsofluxTM is based on of an array pixels nucleus cytokeratin expression excluding CD45 signal. Total including free were evaluated healthy donor samples mixed cells (PCCs) from ductal adenocarcinoma (PDAC). manual was used blinded...
Nitric oxide (NO) plays a relevant role during cell death regulation in tumor cells. The overexpression of nitric synthase type III (NOS-3) induces oxidative and nitrosative stress, p53 receptor expression apoptosis hepatoblastoma S-nitrosylation modulates apoptosis. Sorafenib is the unique recommended molecular-targeted drug for treatment patients with advanced hepatocellular carcinoma. present study was addressed to elucidate potential NO Sorafenib-induced HepG2 We determined intra-...
Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of hepatocarcinoma (HCC) with potential portal hypertension and/or bilirubinemia, but without vascular-associated diseases. The are receiving immunosuppressive therapy to reduce graft rejection, differential side effects have been related calcineurin and mTOR inhibitor administration regarding tumor recurrence nephrotoxicity. in vitro studies showed that Tacrolimus exerted a more potent...
Background/Aims: Orthotopic liver transplantation (OLT) is the recommended treatment for patients at early stages of hepatocarcinoma (HCC) with portal hypertension and/or increased bilirubinemia, but without vascular-associated diseases.Tumor recurrence, which main drawback survival submitted to OLT HCC, has been related tumor-related variables and immunosuppressive therapies.We have previously shown that Tacrolimus (FK506) exerts a more potent pro-apoptotic anti-proliferative effects than...
Hepatocellular carcinoma (HCC) is the sixth most common neoplasia and fourth cause of cancer-related mortality worldwide. Sorafenib first-line molecular therapy for patients in an advanced stage HCC. However, recommended clinical dose associated with several complications, which derive from its lack cell specificity very low water solubility. To circumvent these drawbacks, present study we developed two sugar-coated polydiacetylene-based nanomicelles-Sorafenib carriers targeting mannose...
Patients with hepatocellular carcinoma (HCC) submitted to orthotopic liver transplantation (OLT) have a variable 5-year survival rate limited mostly by tumor recurrence. The etiology, age, sex, alcohol, Child-Pugh, and the immunesuppressor been associated tumour expression of ΔNp73 is related reduced patients HCC. study evaluated p63 p73 isoforms cell death receptors, their relation recurrence survival. results were in vitro validated HCC lines.HCC sections from OLT used. was done...
Circulating tumor cells (CTCs) enumeration is a promising technique to predict cancer prognosis and treatment response. CTCs were evaluated in healthy subjects, cirrhotic controls hepatocarcinoma (HCC) patients. isolated using microfluidic system based on the expression of EpCAM, EGFR three epithelial mesenchymal transition (EMT) markers. Patients stratified according disease progression exitus. Although counts individual CTCs, clustered α-fetoprotein (AFP) at basal level patients...