A5088297525- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Cancer Mechanisms and Therapy
- Vascular Tumors and Angiosarcomas
- Neurofibromatosis and Schwannoma Cases
- Melanoma and MAPK Pathways
- Oral and Maxillofacial Pathology
- Lymphoma Diagnosis and Treatment
- Cutaneous Melanoma Detection and Management
- Breast Lesions and Carcinomas
- Neuroblastoma Research and Treatments
- Glycosylation and Glycoproteins Research
- Gastrointestinal Tumor Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer and Skin Lesions
- PI3K/AKT/mTOR signaling in cancer
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Genetic and Kidney Cyst Diseases
- Breast Implant and Reconstruction
- Genetic and rare skin diseases.
Laboratório Bacchi
2019-2024
Hospital de Câncer de Barretos
2013-2023
GTx (United States)
2017
Mayo Clinic
2015
University of Minho
2015
MicroRNAs (miRNAs) are small, non-coding RNA molecules involved in post-transcriptional gene regulation and have recently been shown to play a role cancer metastasis. In solid tumors, especially breast cancer, alterations miRNA expression contribute pathogenesis, including Considering the emerging of miRNAs metastasis, identification predictive markers is necessary further understanding stage-specific development. This retrospective analysis that aimed identify molecular biomarkers related...
AIM:To compare the performance of three commercially available anti-human epidermalgrowth factor re-ceptor 2 (HER2) antibodies in whole-tissue sections and tissue microarrays (TMAs) a series gastric tumors. METHODS:We present comparative analysis anti-HER2 (HercepTest, 4B5 SP3) using TMA prepared from same paraffin blocks 199 adenocarcinomas operated upon between January 2004 December 2008 at Brazilian cancer hospital.The data on patients' age, sex, anatomical location tumor Lauren's...
Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite current therapeutic advances, still confer poor outcome to half the patients. As other solid tumors, STSs exhibit high glucose consumption rates, associated with worse prognosis and response. highly glycolytic we hypothesized that should present an increased expression lactate transporters (MCTs). Immunohistochemical MCT1, MCT2, MCT4 CD147 was assessed in series 86 profiles were patients' clinical-pathological parameters....
OBJECTIVE:To evaluate ipsilateral breast tumor recurrence after breast-conserving surgery for locally advanced cancer.METHODS: A retrospective observational cohort study was performed in patients with cancer submitted to neoadjuvant chemotherapy based on an adriamycincyclophosphamide-paclitaxel regimen.We evaluated the clinical, pathologic, immunohistochemistry, and surgical factors that contribute locoregional recurrence.A Kaplan-Meier analysis Cox model were used main related disease-free...
Here, we analyze a series of soft tissue sarcomas (STS), which are heterogeneous group mesenchymal neoplasms, for the presence and frequency microsatellite instability (MSI). MSI has been proposed to be clinically relevant colorectal cancer, yet on STS its role is not consensual, partly due limited number cases analyzed methodology issues.The detailed evaluation in tumor samples from 71 patients was performed by pentaplex PCR markers NR-27, NR-21, NR-24, BAT-25, BAT-26, followed capillary...
Paralaryngeal mass with secondary extension to the thyroid cartilage involving confluent cysts, subjected conservative surgical treatment a diagnosis of giant cell tumor soft tissues, neoplasm morphologically similar but genetically unrelated osseous tumors.
Introduction Oncogenic hotspot mutations in the promoter region of TERT gene have been identified several cancer types as being associated with a worse outcome. Additionally, polymorphism (rs2853669) TERTpromoter was reported to modify survival TERT-mutated patients. Our aim is determine frequency c.-124 C>T and c.-146 genotype rs2853669 series 68 soft tissue sarcomas (STS) comprising 22 histological subtypes. Methods PCR performed, followed by direct sequencing fragment containing...
Immediate implant-based breast reconstruction (IBBR) is rarely performed in patients with locally advanced carcinoma (LABC). It has not been considered the best indication, and literature scarce about this subject.A retrospective matched case-control study was LABC submitted to neoadjuvant chemotherapy (NCT). Forty-eight undergoing immediate IBBR were 96 conventional mastectomy. Patients according 2 models based on prognostic characteristics prior NCT response NCT. Local recurrence...
Aim: The Ewing sarcoma family of tumors (ESFT) is a group malignant small round cell neoplasms bones and soft tissues closely histogenetically related. Methylthioadenosine phosphorylase (MTAP) deficiency has been recently associated with increased tumor aggressiveness poor outcomes in different types neoplasms. However, the expression this biomarker its biological role ESFT remain largely unknown. Methods: Immunohistochemical MTAP was accessed 112 patients tissue microarray platform...
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA has frequently reported sporadic breast cancers, but few studies focused on profiling hereditary cancers. In this study, we aimed to identify specific signatures tumors compare with cancer normal tissues.Global using NanoString technology was performed 43 (15 BRCA1, 14 BRCA2, BRCAX), 23 8 tissues. These tissues...
Patients with Beckwith-Wiedemann syndrome (BWS) are known to be at an increased risk for childhood malignancies, particularly Wilms tumor and hepatoblastoma. We report a case of genetically confirmed BWS in 5-month-old girl who presented 9.5-cm abdominal mass associated elevated α-fetoprotein levels. The clinical impression was strongly suggestive Histologic examination the surgically excised revealed mesenchymal hamartoma liver (MHL), benign hepatic neoplasm.
Epithelioid sarcoma is a distinct type with specific morphology and immunophenotype. An epithelioid of the vulva an extremely rare aggressive tumor most commonly occurs on labia majora in women reproductive age. Only few cases have been reported, especially presence focal myxoid changes. Early diagnosis difficult because its benign appearance as painless subcutaneous nodule. Optimal treatment not well established due to rarity. We report successfully approached case vulvar that occurred...
Aim: The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out 35 cases showed (11.4%) only 26 CM presented (3.9%). was observed an patient that presents lack MSH6 immunostaining...
Angiomatoid fibrous histiocytoma (AFH) is a rarely metastasizing neoplasm that typically occurs in the deep dermis and subcutis of extremities young patients, characterized by t(2;22) translocation involving EWSR1 CREB1 . Because its distinctive histologic features, diagnosis AFH generally straightforward, although immunohistochemistry (IHC) findings are relatively nonspecific. We recently encountered case primary cranial showed strong MUC4 IHC expression, which has not yet been reported...
Sarcomas represent less than 1% of all solid neoplasms in adults and over 20% children. Their etiology is unclear, but genetic susceptibility plays an important role this scenario. Sarcoma central Li-Fraumeni Syndrome (LFS), a familial predisposition cancer syndrome. In Brazil, the high prevalence p.Arg337His mutations TP53 gene brings about unique condition: cluster LFS. present work, we studied 502 sarcoma patients not selected by age or family history attempt to assess impact so-called...
<b><i>Objective:</i></b> Soft tissue sarcomas (STSs) are heterogeneous tumors displaying multiple and complex molecular abnormalities with no specific pattern. Despite current therapeutic advances, the patients STS still have a poor outcome, which makes it necessary to find out new prognostic markers. The Raf kinase inhibitory protein (RKIP) has been associated prognosis in several human neoplasms; however, its role is unknown....
Abstract Background Gastrointestinal stromal tumors (GIST) represent a significant clinical challenge due to their metastatic potential and limited treatment options. Raf kinase inhibitor protein (RKIP), suppressor of the MAPK signaling pathway, is downregulated in various cancers acts as metastasis suppressor. Our previous studies demonstrated low RKIP expression GIST its association with poor outcomes. This study aimed expand on findings investigate biological therapeutic implications loss...
Abstract Background Benign metastasizing leiomyoma (BML) is a smooth muscle tumour of genital origin occurring in women with history uterine or pelvic leiomyoma. Although histologically benign, it exhibits metastatic behaviour. Lungs are the most common site metastasis. The heart rare and metastasis at this location has been described just few cases. Case summary A 42-year-old woman resected subsequent still not-resected left periovarian solid mass began complaining shortness breath 2 weeks...
Fat-forming solitary fibrous tumor (SFT) is a rare variant of tumor, mesenchymal fibroblastic neoplasia with particular branching hypervascular pattern. This usually classified as benign and only very few fat-forming SFTs malignant histologic features have been reported. We report histologically in 61-year-old man, located his neck. Ultrasonography examination was first performed showing heterogeneous lesion, predominantly hyperechoic, sound beam attenuation, containing two hypoechoic solid...
The patient was a 54-year-old Brazilian woman presenting progressive mass in the right breast. clinical exam showed 9 x 8 cm tumor and hardened axillary lymph node. It clinically considered T3N1M0 breast (Figure 1A). Mammography multiple oval formations, occupying whole 2A). Ultrasonography presence of cysts, many which containing vegetating lesions with intense vascular flow 2B) absence lesion. Magnetic resonance imaging cysts associated vegetative lesions, 4.7cm infiltrative area near...